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Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study.

Hlebowicz, Joanna LU ; Darwiche, Ghassan LU ; Björgell, Ola LU and Almér, Lars-Olof LU (2007) In BMC Gastroenterology 7(1).
Abstract
ABSTRACT: BACKGROUND: Previous studies on healthy people show that vinegar delays gastric emptying and lowers postprandial blood glucose and insulin levels. The aim of this study was to investigate the effect of apple cider vinegar on delayed gastric emptying rate on diabetes mellitus patients. METHODS: Ten patients with type 1 diabetes and diabetic gastroparesis, including one patient who had undergone vagotomy, were included and completed the investigator blinded crossover trial. The gastric emptying rate (GER) was measured using standardized real-time ultrasonography. The GER was calculated as the percentage change in the antral cross-sectional area 15 and 90 minutes after ingestion of 300 g rice pudding and 200 ml water (GER1), or 300... (More)
ABSTRACT: BACKGROUND: Previous studies on healthy people show that vinegar delays gastric emptying and lowers postprandial blood glucose and insulin levels. The aim of this study was to investigate the effect of apple cider vinegar on delayed gastric emptying rate on diabetes mellitus patients. METHODS: Ten patients with type 1 diabetes and diabetic gastroparesis, including one patient who had undergone vagotomy, were included and completed the investigator blinded crossover trial. The gastric emptying rate (GER) was measured using standardized real-time ultrasonography. The GER was calculated as the percentage change in the antral cross-sectional area 15 and 90 minutes after ingestion of 300 g rice pudding and 200 ml water (GER1), or 300 g rice pudding and 200 ml water with 30 ml apple cider vinegar (GER2). The subjects drank 200 ml water daily before breakfast one week before the measurement of GER1. The same subjects drank 200 ml water with 30 ml vinegar daily before breakfast for two weeks before the measurement of GER2. RESULTS: The median values of GER1 and GER2 were 27% and 17%, respectively. The effect of vinegar on the rate of gastric emptying was statistically significant (p < 0.05). CONCLUSION: This study shows that vinegar affects insulin-dependent diabetes mellitus patients with diabetic gastroparesis by reducing the gastric emptying rate even further, and this might be a disadvantage regarding to their glycaemic control. TRIAL REGISTRATION NUMBER: ISRCTN33841495. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Gastroenterology
volume
7
issue
1
publisher
BMC Biomedical Centre, Lund University
external identifiers
  • pmid:18093343
  • wos:000253320400001
  • scopus:39549110201
ISSN
1471-230X
DOI
10.1186/1471-230X-7-46
language
English
LU publication?
yes
id
0f45ddc1-5cfd-408c-85ac-5b2f5eb4f13f (old id 1035068)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18093343?dopt=Abstract
date added to LUP
2008-04-01 15:36:06
date last changed
2017-09-24 04:18:36
@article{0f45ddc1-5cfd-408c-85ac-5b2f5eb4f13f,
  abstract     = {ABSTRACT: BACKGROUND: Previous studies on healthy people show that vinegar delays gastric emptying and lowers postprandial blood glucose and insulin levels. The aim of this study was to investigate the effect of apple cider vinegar on delayed gastric emptying rate on diabetes mellitus patients. METHODS: Ten patients with type 1 diabetes and diabetic gastroparesis, including one patient who had undergone vagotomy, were included and completed the investigator blinded crossover trial. The gastric emptying rate (GER) was measured using standardized real-time ultrasonography. The GER was calculated as the percentage change in the antral cross-sectional area 15 and 90 minutes after ingestion of 300 g rice pudding and 200 ml water (GER1), or 300 g rice pudding and 200 ml water with 30 ml apple cider vinegar (GER2). The subjects drank 200 ml water daily before breakfast one week before the measurement of GER1. The same subjects drank 200 ml water with 30 ml vinegar daily before breakfast for two weeks before the measurement of GER2. RESULTS: The median values of GER1 and GER2 were 27% and 17%, respectively. The effect of vinegar on the rate of gastric emptying was statistically significant (p &lt; 0.05). CONCLUSION: This study shows that vinegar affects insulin-dependent diabetes mellitus patients with diabetic gastroparesis by reducing the gastric emptying rate even further, and this might be a disadvantage regarding to their glycaemic control. TRIAL REGISTRATION NUMBER: ISRCTN33841495.},
  articleno    = {46},
  author       = {Hlebowicz, Joanna and Darwiche, Ghassan and Björgell, Ola and Almér, Lars-Olof},
  issn         = {1471-230X},
  language     = {eng},
  number       = {1},
  publisher    = {BMC Biomedical Centre, Lund University},
  series       = {BMC Gastroenterology},
  title        = {Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study.},
  url          = {http://dx.doi.org/10.1186/1471-230X-7-46},
  volume       = {7},
  year         = {2007},
}