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Probiotics and Blueberry Attenuate the Severity of Dextran Sulfate Sodium (DSS)-Induced Colitis.

Osman, Nadia LU ; Adawi, Diya LU ; Ahrné, Siv LU ; Jeppsson, Bengt LU and Molin, Göran LU (2008) In Digestive Diseases and Sciences 53. p.2464-2473
Abstract
We studied the anti-inflammatory properties of probiotic strains and blueberry in a colitis model. The disease activity index (DAI) was significantly lower on days 9 and 10 in all groups compared to the colitis control. Myeloperoxidase (MPO) and bacterial translocation to the liver and to the mesenteric lymph nodes (MLN) decreased significantly in all groups compared to colitis control. Cecal Enterobacteriaceae count decreased significantly in blueberry with and without probiotics compared to the other groups. Lactobacillus plantarum reisolated from the cecal content in the presence of blueberry, contrary to Lactobacillus fermentum. Colonic MDA decreased significantly in all groups, except the L. fermentum group, compared to the colitis... (More)
We studied the anti-inflammatory properties of probiotic strains and blueberry in a colitis model. The disease activity index (DAI) was significantly lower on days 9 and 10 in all groups compared to the colitis control. Myeloperoxidase (MPO) and bacterial translocation to the liver and to the mesenteric lymph nodes (MLN) decreased significantly in all groups compared to colitis control. Cecal Enterobacteriaceae count decreased significantly in blueberry with and without probiotics compared to the other groups. Lactobacillus plantarum reisolated from the cecal content in the presence of blueberry, contrary to Lactobacillus fermentum. Colonic MDA decreased significantly in all groups, except the L. fermentum group, compared to the colitis control. The cecal concentration of acetic, propionic, and butyricbutyric acid was significantly higher in the L. plantarum group, while the L. fermentum group yielded the highest concentration of lactic acid compared with all other groups. Lactobacillus plantarum DSM 15313, Lactobacillus fermentum 35D, and blueberry alone and in combination improve the DAI, reduce bacterial translocation, and reduce inflammation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Digestive Diseases and Sciences
volume
53
pages
2464 - 2473
publisher
Springer
external identifiers
  • pmid:18274903
  • wos:000258601800024
  • scopus:50249139552
ISSN
1573-2568
DOI
10.1007/s10620-007-0174-x
language
English
LU publication?
yes
id
05e04bd4-b34b-4742-9fc7-c6237babcd8b (old id 1041935)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18274903?dopt=Abstract
date added to LUP
2008-03-06 13:52:52
date last changed
2017-07-23 03:38:03
@article{05e04bd4-b34b-4742-9fc7-c6237babcd8b,
  abstract     = {We studied the anti-inflammatory properties of probiotic strains and blueberry in a colitis model. The disease activity index (DAI) was significantly lower on days 9 and 10 in all groups compared to the colitis control. Myeloperoxidase (MPO) and bacterial translocation to the liver and to the mesenteric lymph nodes (MLN) decreased significantly in all groups compared to colitis control. Cecal Enterobacteriaceae count decreased significantly in blueberry with and without probiotics compared to the other groups. Lactobacillus plantarum reisolated from the cecal content in the presence of blueberry, contrary to Lactobacillus fermentum. Colonic MDA decreased significantly in all groups, except the L. fermentum group, compared to the colitis control. The cecal concentration of acetic, propionic, and butyricbutyric acid was significantly higher in the L. plantarum group, while the L. fermentum group yielded the highest concentration of lactic acid compared with all other groups. Lactobacillus plantarum DSM 15313, Lactobacillus fermentum 35D, and blueberry alone and in combination improve the DAI, reduce bacterial translocation, and reduce inflammation.},
  author       = {Osman, Nadia and Adawi, Diya and Ahrné, Siv and Jeppsson, Bengt and Molin, Göran},
  issn         = {1573-2568},
  language     = {eng},
  pages        = {2464--2473},
  publisher    = {Springer},
  series       = {Digestive Diseases and Sciences},
  title        = {Probiotics and Blueberry Attenuate the Severity of Dextran Sulfate Sodium (DSS)-Induced Colitis.},
  url          = {http://dx.doi.org/10.1007/s10620-007-0174-x},
  volume       = {53},
  year         = {2008},
}