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Cord blood islet autoantibodies and seasonal association with the type 1 diabetes high-risk genotype.

Lynch, Kristian LU ; Lernmark, Barbro LU ; Merlo, Juan LU orcid ; Cilio, Maria Roberta ; Ivarsson, S-A ; Lernmark, Åke LU orcid and Carlsson, Annelie LU orcid (2008) In Journal of Perinatology 28(3). p.211-217
Abstract
Objective:Human leukocyte antigen DQ (HLA-DQ) genetic factors and islet autoantibodies are strongly associated with type 1 diabetes (T1D) and are currently used to predict T1D. This study examined whether islet autoantibodies in the cord blood of newborns to nondiabetic mothers were associated with the (T1D) high-risk genotype HLA-DQ2/8, gestational infections or both.Study Design:Cord blood samples were taken from 33 683 newborns and used for HLA typing and analyses of islet autoantibodies. Parents completed questionnaires when the child was 2 months of age.Result:The prevalence of newborn islet autoantibodies consistently varied with season over 4 years (P<0.0001); lowest in first quarter (1.2%) and highest in third (2.4%). Cord blood... (More)
Objective:Human leukocyte antigen DQ (HLA-DQ) genetic factors and islet autoantibodies are strongly associated with type 1 diabetes (T1D) and are currently used to predict T1D. This study examined whether islet autoantibodies in the cord blood of newborns to nondiabetic mothers were associated with the (T1D) high-risk genotype HLA-DQ2/8, gestational infections or both.Study Design:Cord blood samples were taken from 33 683 newborns and used for HLA typing and analyses of islet autoantibodies. Parents completed questionnaires when the child was 2 months of age.Result:The prevalence of newborn islet autoantibodies consistently varied with season over 4 years (P<0.0001); lowest in first quarter (1.2%) and highest in third (2.4%). Cord blood islet autoantibodies were associated with HLA-DQ2/8 in the second (OR, 2.30; P=0.02), third (OR, 2.12; P=0.008) and fourth quarters (OR, 2.49; P=0.007), but not in the first (OR, 1.13). Reported gastroenteritis was additionally associated with islet autoantibodies in the third quarter (OR, 1.80, P=0.04).Conclusion:An association between HLA and islet autoimmunity may depend on environmental exposure during pregnancy. Follow-up of mothers and children will determine risk of T1D.Journal of Perinatology (2008) 28, 211-217; doi:10.1038/sj.jp.7211912; published online 14 February 2008. (Less)
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publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Perinatology
volume
28
issue
3
pages
211 - 217
publisher
Nature Publishing Group
external identifiers
  • pmid:18273032
  • wos:000254415600009
  • scopus:40349100434
ISSN
0743-8346
DOI
10.1038/sj.jp.7211912
language
English
LU publication?
yes
id
c1f51f10-da03-4087-964d-f6066eea4516 (old id 1041970)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18273032?dopt=Abstract
date added to LUP
2016-04-04 08:55:12
date last changed
2022-05-28 04:12:37
@article{c1f51f10-da03-4087-964d-f6066eea4516,
  abstract     = {{Objective:Human leukocyte antigen DQ (HLA-DQ) genetic factors and islet autoantibodies are strongly associated with type 1 diabetes (T1D) and are currently used to predict T1D. This study examined whether islet autoantibodies in the cord blood of newborns to nondiabetic mothers were associated with the (T1D) high-risk genotype HLA-DQ2/8, gestational infections or both.Study Design:Cord blood samples were taken from 33 683 newborns and used for HLA typing and analyses of islet autoantibodies. Parents completed questionnaires when the child was 2 months of age.Result:The prevalence of newborn islet autoantibodies consistently varied with season over 4 years (P&lt;0.0001); lowest in first quarter (1.2%) and highest in third (2.4%). Cord blood islet autoantibodies were associated with HLA-DQ2/8 in the second (OR, 2.30; P=0.02), third (OR, 2.12; P=0.008) and fourth quarters (OR, 2.49; P=0.007), but not in the first (OR, 1.13). Reported gastroenteritis was additionally associated with islet autoantibodies in the third quarter (OR, 1.80, P=0.04).Conclusion:An association between HLA and islet autoimmunity may depend on environmental exposure during pregnancy. Follow-up of mothers and children will determine risk of T1D.Journal of Perinatology (2008) 28, 211-217; doi:10.1038/sj.jp.7211912; published online 14 February 2008.}},
  author       = {{Lynch, Kristian and Lernmark, Barbro and Merlo, Juan and Cilio, Maria Roberta and Ivarsson, S-A and Lernmark, Åke and Carlsson, Annelie}},
  issn         = {{0743-8346}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{211--217}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Journal of Perinatology}},
  title        = {{Cord blood islet autoantibodies and seasonal association with the type 1 diabetes high-risk genotype.}},
  url          = {{http://dx.doi.org/10.1038/sj.jp.7211912}},
  doi          = {{10.1038/sj.jp.7211912}},
  volume       = {{28}},
  year         = {{2008}},
}