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Atrial myocardial pathoelectrophysiology in adults with a secundum atrial septal defect is unaffected by closure of the defect. A study using high resolution signal-averaged orthogonal P-wave technique.

Thilén, Ulf LU ; Carlson, Jonas LU ; Platonov, Pyotr LU and Olsson, Bertil LU (2009) In International Journal of Cardiology 132. p.364-368
Abstract
BACKGROUND: In patients with atrial septal defect (ASD) the P-wave is prolonged as a marker of delayed atrial conduction which is associated with atrial fibrillation. The study aim was to analyse the impact of ASD closure in adults on P-wave duration and morphology by means of signal-averaged P-waves (PSA-ECG) and to investigate potential mechano-electrical interactions. METHODS: PSA-ECG was obtained before and 8+/-6 months after ASD closure in 35 adult patients (age 53+/-15 years). Heart chamber sizes and pulmonary artery pressure levels were assessed by echoDopplercardiography. RESULTS: P-wave duration and morphology did not change after ASD closure (148+/-16 vs 144+/-16 ms, P=0.07). P-wave duration did not relate to age at repair,... (More)
BACKGROUND: In patients with atrial septal defect (ASD) the P-wave is prolonged as a marker of delayed atrial conduction which is associated with atrial fibrillation. The study aim was to analyse the impact of ASD closure in adults on P-wave duration and morphology by means of signal-averaged P-waves (PSA-ECG) and to investigate potential mechano-electrical interactions. METHODS: PSA-ECG was obtained before and 8+/-6 months after ASD closure in 35 adult patients (age 53+/-15 years). Heart chamber sizes and pulmonary artery pressure levels were assessed by echoDopplercardiography. RESULTS: P-wave duration and morphology did not change after ASD closure (148+/-16 vs 144+/-16 ms, P=0.07). P-wave duration did not relate to age at repair, preclosure atrial sizes or pulmonary artery pressure. Pre- or postclosure atrial fibrillation propensity was associated with longer P-wave duration both before and after ASD closure. CONCLUSION: Atrial conduction disturbances in middle-aged patients with ASD, manifested as a prolonged P-wave duration, do not change after ASD closure and are not related to the dilatation of the right and left atria. It is suggestive that atrial conduction disturbance associated with ASD develop early and early intervention is required to prevent the development of late atrial fibrillation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
P-wave duration, Signal-averaged P-wave ECG, Atrial septal defect, Atrial fibrillation, Electric remodelling, Closure of atrial septal defect
in
International Journal of Cardiology
volume
132
pages
5 pages
publisher
Elsevier
external identifiers
  • pmid:18242736
  • wos:000263892200010
  • scopus:60649102050
ISSN
0167-5273
DOI
10.1016/j.ijcard.2007.11.101
language
English
LU publication?
yes
id
3e9b2259-a5a8-4cd9-9a92-08887684ab0e (old id 1042324)
date added to LUP
2008-03-06 15:27:41
date last changed
2017-01-01 04:41:46
@article{3e9b2259-a5a8-4cd9-9a92-08887684ab0e,
  abstract     = {BACKGROUND: In patients with atrial septal defect (ASD) the P-wave is prolonged as a marker of delayed atrial conduction which is associated with atrial fibrillation. The study aim was to analyse the impact of ASD closure in adults on P-wave duration and morphology by means of signal-averaged P-waves (PSA-ECG) and to investigate potential mechano-electrical interactions. METHODS: PSA-ECG was obtained before and 8+/-6 months after ASD closure in 35 adult patients (age 53+/-15 years). Heart chamber sizes and pulmonary artery pressure levels were assessed by echoDopplercardiography. RESULTS: P-wave duration and morphology did not change after ASD closure (148+/-16 vs 144+/-16 ms, P=0.07). P-wave duration did not relate to age at repair, preclosure atrial sizes or pulmonary artery pressure. Pre- or postclosure atrial fibrillation propensity was associated with longer P-wave duration both before and after ASD closure. CONCLUSION: Atrial conduction disturbances in middle-aged patients with ASD, manifested as a prolonged P-wave duration, do not change after ASD closure and are not related to the dilatation of the right and left atria. It is suggestive that atrial conduction disturbance associated with ASD develop early and early intervention is required to prevent the development of late atrial fibrillation.},
  author       = {Thilén, Ulf and Carlson, Jonas and Platonov, Pyotr and Olsson, Bertil},
  issn         = {0167-5273},
  keyword      = {P-wave duration,Signal-averaged P-wave ECG,Atrial septal defect,Atrial fibrillation,Electric remodelling,Closure of atrial septal defect},
  language     = {eng},
  pages        = {364--368},
  publisher    = {Elsevier},
  series       = {International Journal of Cardiology},
  title        = {Atrial myocardial pathoelectrophysiology in adults with a secundum atrial septal defect is unaffected by closure of the defect. A study using high resolution signal-averaged orthogonal P-wave technique.},
  url          = {http://dx.doi.org/10.1016/j.ijcard.2007.11.101},
  volume       = {132},
  year         = {2009},
}