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Protein D of Haemophilus influenzae: a protective nontypeable H. influenzae antigen and a carrier for pneumococcal conjugate vaccines.

Forsgren, Arne LU ; Riesbeck, Kristian LU and Janson, Håkan LU (2008) In Clinical Infectious Diseases 46(5). p.726-731
Abstract
Protein D (PD) is a highly conserved 42 kDa surface lipoprotein found in all Haemophilus influenzae, including nontypeable (NT) H. influenzae. PD is involved in the pathogenesis of respiratory tract infections, in the context of which it has been shown to impair ciliary function in a human nasopharyngeal tissue culture model and to augment the capacity to cause otitis media in rats. A likely mechanism indicating that PD is a virulence factor is its glycerophosphodiesterase activity, which leads to the release of phosphorylcholine from host epithelial cells. PD has been demonstrated to be a promising vaccine candidate against experimental NT H. influenzae infection. Rats vaccinated with PD cleared NT H. influenzae better after middle ear... (More)
Protein D (PD) is a highly conserved 42 kDa surface lipoprotein found in all Haemophilus influenzae, including nontypeable (NT) H. influenzae. PD is involved in the pathogenesis of respiratory tract infections, in the context of which it has been shown to impair ciliary function in a human nasopharyngeal tissue culture model and to augment the capacity to cause otitis media in rats. A likely mechanism indicating that PD is a virulence factor is its glycerophosphodiesterase activity, which leads to the release of phosphorylcholine from host epithelial cells. PD has been demonstrated to be a promising vaccine candidate against experimental NT H. influenzae infection. Rats vaccinated with PD cleared NT H. influenzae better after middle ear and pulmonary bacterial challenge, and chinchillas vaccinated with PD showed significant protection against NT H. influenzae-dependent acute otitis media. In a clinical trial involving children, PD was used as an antigenically active carrier protein in an 11-valent pneumococcal conjugate investigational vaccine; significant protection was achieved against acute otitis media not only caused by pneumococci but also caused by NT H. influenzae. This may have great clinical implications, because PD is the first NT H. influenzae antigen that has induced protective responses in humans. (Less)
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keywords
Bacterial Proteins: immunology, Antigens, Bacterial: immunology, Carrier Proteins: immunology, Haemophilus Infections: immunology, Haemophilus Vaccines: immunology, Haemophilus influenzae: immunology, Immunoglobulin D: immunology, Lipoproteins: immunology, Otitis Media: immunology, Pneumococcal Infections: immunology, Otitis Media: microbiology, Pneumococcal Vaccines: immunology, Pneumonia: immunology, Pneumonia: microbiology, Vaccines, Conjugate: immunology, Virulence Factors: immunology
in
Clinical Infectious Diseases
volume
46
issue
5
pages
726 - 731
publisher
The Infectious Diseases Society of America
external identifiers
  • pmid:18230042
  • wos:000253453700013
  • scopus:39749203489
ISSN
1537-6591
DOI
10.1086/527396
language
English
LU publication?
yes
id
4467c6e9-172e-4c2d-aeba-a2af29e0203d (old id 1042544)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18230042?dopt=Abstract
date added to LUP
2008-03-04 11:13:45
date last changed
2017-09-24 03:27:18
@article{4467c6e9-172e-4c2d-aeba-a2af29e0203d,
  abstract     = {Protein D (PD) is a highly conserved 42 kDa surface lipoprotein found in all Haemophilus influenzae, including nontypeable (NT) H. influenzae. PD is involved in the pathogenesis of respiratory tract infections, in the context of which it has been shown to impair ciliary function in a human nasopharyngeal tissue culture model and to augment the capacity to cause otitis media in rats. A likely mechanism indicating that PD is a virulence factor is its glycerophosphodiesterase activity, which leads to the release of phosphorylcholine from host epithelial cells. PD has been demonstrated to be a promising vaccine candidate against experimental NT H. influenzae infection. Rats vaccinated with PD cleared NT H. influenzae better after middle ear and pulmonary bacterial challenge, and chinchillas vaccinated with PD showed significant protection against NT H. influenzae-dependent acute otitis media. In a clinical trial involving children, PD was used as an antigenically active carrier protein in an 11-valent pneumococcal conjugate investigational vaccine; significant protection was achieved against acute otitis media not only caused by pneumococci but also caused by NT H. influenzae. This may have great clinical implications, because PD is the first NT H. influenzae antigen that has induced protective responses in humans.},
  author       = {Forsgren, Arne and Riesbeck, Kristian and Janson, Håkan},
  issn         = {1537-6591},
  keyword      = {Bacterial Proteins: immunology,Antigens,Bacterial: immunology,Carrier Proteins: immunology,Haemophilus Infections: immunology,Haemophilus Vaccines: immunology,Haemophilus influenzae: immunology,Immunoglobulin D: immunology,Lipoproteins: immunology,Otitis Media: immunology,Pneumococcal Infections: immunology,Otitis Media: microbiology,Pneumococcal Vaccines: immunology,Pneumonia: immunology,Pneumonia: microbiology,Vaccines,Conjugate: immunology,Virulence Factors: immunology},
  language     = {eng},
  number       = {5},
  pages        = {726--731},
  publisher    = {The Infectious Diseases Society of America},
  series       = {Clinical Infectious Diseases},
  title        = {Protein D of Haemophilus influenzae: a protective nontypeable H. influenzae antigen and a carrier for pneumococcal conjugate vaccines.},
  url          = {http://dx.doi.org/10.1086/527396},
  volume       = {46},
  year         = {2008},
}