Advanced

Glycaemic Response in Relation to Gastric Emptying and Satiety in Health and Disease

Hlebowicz, Joanna LU (2008) In Lund University, Faculty of Medicine Doctoral Dissertation Series 2008:41.
Abstract
Dietary fibre and whole grains are recommended to prevent the development of type 2 diabetes. Low glycaemic index foods that are rich in fibre are recommended to control blood glucose levels. Gastric emptying, together with other factors, regulate the postprandial blood glucose response. A delay in the gastric emptying rate (GER) leads to a lower postprandial blood glucose concentration. However, 30-50% of diabetes patients have delayed gastric emptying.The aims of these studies were to evaluate the effect of different food factors on the GER, the postprandial blood glucose response, and satiety in healthy subjects and those with diabetes mellitus. The results show that inclusion of 6 g cinnamon in the diet lowers the postprandial blood... (More)
Dietary fibre and whole grains are recommended to prevent the development of type 2 diabetes. Low glycaemic index foods that are rich in fibre are recommended to control blood glucose levels. Gastric emptying, together with other factors, regulate the postprandial blood glucose response. A delay in the gastric emptying rate (GER) leads to a lower postprandial blood glucose concentration. However, 30-50% of diabetes patients have delayed gastric emptying.The aims of these studies were to evaluate the effect of different food factors on the GER, the postprandial blood glucose response, and satiety in healthy subjects and those with diabetes mellitus. The results show that inclusion of 6 g cinnamon in the diet lowers the postprandial blood glucose response, a change that is at least partially explained by delayed GER. Neither bran flakes nor wholemeal oat flakes has any effect on the total postprandial blood glucose response, GER or satiety compared with cornflakes. Muesli with 4 g oat β-glucan does not affect the GER or satiety, but lowers the postprandial blood glucose response, indicating that the GER is not involved in the blood glucose lowering mechanism. Whole-kernel wheat bread served with vinegar leads to higher satiety than wholemeal wheat bread with vinegar, or white wheat bread with or without vinegar in healthy subjects. This may be explained by increased antral distension caused by intact cereal kernels, but not by changes in GER or postprandial blood glucose responses. Vinegar affects insulin-dependent diabetes mellitus patients with diabetic gastroparesis by reducing the GER even further. (Less)
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • Professor Hellström, Per, Karolinska Institute, Department of Gastroenterology and Hepatology, Karolinska University Hospital, Stockholm, Sweden
organization
publishing date
type
Thesis
publication status
published
subject
keywords
Diabetes, Cinnamon, Satiety, Healthy subjects, Gastroparesis, Blood Glucose, Ultrasound, Gastric emptying, Whole-kernel, Dietary fibre, Beta-glucan, Wheat, Oat
in
Lund University, Faculty of Medicine Doctoral Dissertation Series
volume
2008:41
pages
148 pages
publisher
Department of Clinical Sciences, Lund University
defense location
Lecture hall at the Department of Internal Medicin, Entrance 35, Malmö University Hospital, Malmö, Sweden
defense date
2008-04-04 09:15
ISSN
1652-8220
ISBN
978-91-85897-94-0
language
English
LU publication?
yes
id
0d91f5c5-9757-4334-949b-ba2d063575d7 (old id 1044646)
date added to LUP
2008-03-07 10:44:55
date last changed
2016-09-19 08:44:50
@phdthesis{0d91f5c5-9757-4334-949b-ba2d063575d7,
  abstract     = {Dietary fibre and whole grains are recommended to prevent the development of type 2 diabetes. Low glycaemic index foods that are rich in fibre are recommended to control blood glucose levels. Gastric emptying, together with other factors, regulate the postprandial blood glucose response. A delay in the gastric emptying rate (GER) leads to a lower postprandial blood glucose concentration. However, 30-50% of diabetes patients have delayed gastric emptying.The aims of these studies were to evaluate the effect of different food factors on the GER, the postprandial blood glucose response, and satiety in healthy subjects and those with diabetes mellitus. The results show that inclusion of 6 g cinnamon in the diet lowers the postprandial blood glucose response, a change that is at least partially explained by delayed GER. Neither bran flakes nor wholemeal oat flakes has any effect on the total postprandial blood glucose response, GER or satiety compared with cornflakes. Muesli with 4 g oat β-glucan does not affect the GER or satiety, but lowers the postprandial blood glucose response, indicating that the GER is not involved in the blood glucose lowering mechanism. Whole-kernel wheat bread served with vinegar leads to higher satiety than wholemeal wheat bread with vinegar, or white wheat bread with or without vinegar in healthy subjects. This may be explained by increased antral distension caused by intact cereal kernels, but not by changes in GER or postprandial blood glucose responses. Vinegar affects insulin-dependent diabetes mellitus patients with diabetic gastroparesis by reducing the GER even further.},
  author       = {Hlebowicz, Joanna},
  isbn         = {978-91-85897-94-0},
  issn         = {1652-8220},
  keyword      = {Diabetes,Cinnamon,Satiety,Healthy subjects,Gastroparesis,Blood Glucose,Ultrasound,Gastric emptying,Whole-kernel,Dietary fibre,Beta-glucan,Wheat,Oat},
  language     = {eng},
  pages        = {148},
  publisher    = {Department of Clinical Sciences, Lund University},
  school       = {Lund University},
  series       = {Lund University, Faculty of Medicine Doctoral Dissertation Series},
  title        = {Glycaemic Response in Relation to Gastric Emptying and Satiety in Health and Disease},
  volume       = {2008:41},
  year         = {2008},
}