Advanced

Fetal electrocardiographic monitoring during labor in relation to cord blood levels of the brain-injury marker protein S-100.

Stuart, Andrea; Edvinsson, Linda; Källén, Karin LU ; Olofsson, Per LU ; Hellsten, Charlotte LU and Amer-Wåhlin, Isis LU (2008) In Journal of Perinatal Medicine 36(2). p.136-141
Abstract
Abstract Background: Cord artery protein S-100 levels at birth are potential markers of brain damage after asphyxia. Our aim was to investigate if S-100 levels were elevated in neonates with indirect signs of asphyxia during birth. S-100 levels in cord blood were studied in relation to cardiotocography (CTG) and fetal electrocardiography (FECG) changes during birth and to acidemia in umbilical blood. Material and methods: This case-control study was performed in parallel to a large randomized controlled trial (RCT) studying FECG at birth. Protein S-100 samples were collected from 103 neonates at birth and related to the CTG and ECG changes during labor and to pH in umbilical blood. Results: Protein S-100 was significantly higher in... (More)
Abstract Background: Cord artery protein S-100 levels at birth are potential markers of brain damage after asphyxia. Our aim was to investigate if S-100 levels were elevated in neonates with indirect signs of asphyxia during birth. S-100 levels in cord blood were studied in relation to cardiotocography (CTG) and fetal electrocardiography (FECG) changes during birth and to acidemia in umbilical blood. Material and methods: This case-control study was performed in parallel to a large randomized controlled trial (RCT) studying FECG at birth. Protein S-100 samples were collected from 103 neonates at birth and related to the CTG and ECG changes during labor and to pH in umbilical blood. Results: Protein S-100 was significantly higher in neonates with umbilical artery blood pH</=7.05, compared to neonates with pH>7.05. Furthermore, neonates with preterminal CTG patterns showed increased S-100 levels compared to neonates with normal CTG. Neonates having significant CTG and ECG changes, leading to intervention according to clinical guidelines, showed significantly higher S-100 levels compared to neonates without such indication of intervention. Conclusion: A relation exists between S-100 in umbilical blood at birth, acidosis and pathological patterns in CTG and FECG during labor. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Perinatal Medicine
volume
36
issue
2
pages
136 - 141
publisher
De Gruyter
external identifiers
  • pmid:18331207
  • wos:000254578700007
  • scopus:40549137464
ISSN
1619-3997
DOI
10.1515/JPM.2008.019
language
English
LU publication?
yes
id
cd32a658-4178-48b0-92fd-3e7a05cb9e0e (old id 1052673)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18331207?dopt=Abstract
date added to LUP
2008-04-03 08:06:00
date last changed
2017-02-22 10:46:51
@article{cd32a658-4178-48b0-92fd-3e7a05cb9e0e,
  abstract     = {Abstract Background: Cord artery protein S-100 levels at birth are potential markers of brain damage after asphyxia. Our aim was to investigate if S-100 levels were elevated in neonates with indirect signs of asphyxia during birth. S-100 levels in cord blood were studied in relation to cardiotocography (CTG) and fetal electrocardiography (FECG) changes during birth and to acidemia in umbilical blood. Material and methods: This case-control study was performed in parallel to a large randomized controlled trial (RCT) studying FECG at birth. Protein S-100 samples were collected from 103 neonates at birth and related to the CTG and ECG changes during labor and to pH in umbilical blood. Results: Protein S-100 was significantly higher in neonates with umbilical artery blood pH&lt;/=7.05, compared to neonates with pH&gt;7.05. Furthermore, neonates with preterminal CTG patterns showed increased S-100 levels compared to neonates with normal CTG. Neonates having significant CTG and ECG changes, leading to intervention according to clinical guidelines, showed significantly higher S-100 levels compared to neonates without such indication of intervention. Conclusion: A relation exists between S-100 in umbilical blood at birth, acidosis and pathological patterns in CTG and FECG during labor.},
  author       = {Stuart, Andrea and Edvinsson, Linda and Källén, Karin and Olofsson, Per and Hellsten, Charlotte and Amer-Wåhlin, Isis},
  issn         = {1619-3997},
  language     = {eng},
  number       = {2},
  pages        = {136--141},
  publisher    = {De Gruyter},
  series       = {Journal of Perinatal Medicine},
  title        = {Fetal electrocardiographic monitoring during labor in relation to cord blood levels of the brain-injury marker protein S-100.},
  url          = {http://dx.doi.org/10.1515/JPM.2008.019},
  volume       = {36},
  year         = {2008},
}