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Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson's disease

Barker, Roger LU ; Barrett, Jessica; Mason, Sarah L. and Björklund, Anders LU (2013) In Lancet Neurology 12(1). p.84-91
Abstract
Clinical use of allografts of fetal ventral mesencephalic tissue as a treatment to replace dopaminergic neurons in patients with Parkinson's disease was first done more than 20 years ago. Since then, many patients have received transplants, with variable results. During this time, our knowledge of Parkinson's disease has changed and the nature and extent of problems associated with the disorder have been better defined. Our understanding on how best to implement this cell-replacement strategy for patients has grown, but gaining this insight has entailed critical reappraisal of data from transplant trials that have already been undertaken.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Lancet Neurology
volume
12
issue
1
pages
84 - 91
publisher
Lancet Ltd
external identifiers
  • wos:000312429400023
  • scopus:84870772482
ISSN
1474-4465
DOI
10.1016/S1474-4422(12)70295-8
language
English
LU publication?
yes
id
1058be8c-f6d1-4457-9190-ba708e504878 (old id 3400884)
date added to LUP
2013-02-01 07:05:26
date last changed
2019-10-20 03:12:15
@article{1058be8c-f6d1-4457-9190-ba708e504878,
  abstract     = {Clinical use of allografts of fetal ventral mesencephalic tissue as a treatment to replace dopaminergic neurons in patients with Parkinson's disease was first done more than 20 years ago. Since then, many patients have received transplants, with variable results. During this time, our knowledge of Parkinson's disease has changed and the nature and extent of problems associated with the disorder have been better defined. Our understanding on how best to implement this cell-replacement strategy for patients has grown, but gaining this insight has entailed critical reappraisal of data from transplant trials that have already been undertaken.},
  author       = {Barker, Roger and Barrett, Jessica and Mason, Sarah L. and Björklund, Anders},
  issn         = {1474-4465},
  language     = {eng},
  number       = {1},
  pages        = {84--91},
  publisher    = {Lancet Ltd},
  series       = {Lancet Neurology},
  title        = {Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson's disease},
  url          = {http://dx.doi.org/10.1016/S1474-4422(12)70295-8},
  volume       = {12},
  year         = {2013},
}