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Cutaneous sensory nerve fibers are decreased in number after peripheral and central nerve damage.

Wallengren, Joanna LU ; Tegner, Eva LU and Sundler, Frank LU (2002) In Journal of American Academy of Dermatology 46(2). p.215-217
Abstract
Two dermatologic patients displaying peripheral and central nerve damage, respectively, are described. Cutaneous nerve fibers in both patients were studied in skin biopsy specimens taken from neuropathic areas and from the contralateral side, immunocytochemistry being applied to a pan-neuronal marker, a protein gene-product (PGP 9.5). One of the patients, suffering from compression of the ulnar nerve, had dyshidrotic eczema of the hands that was absent on areas of skin that were neuropathic. The cutaneous innervation (most of which was sensory) was reduced by 50% in the neuropathic area as compared with the contralateral side. The other patient had unilateral pruritus on the parethic side after a stroke. The cutaneous innervation of that... (More)
Two dermatologic patients displaying peripheral and central nerve damage, respectively, are described. Cutaneous nerve fibers in both patients were studied in skin biopsy specimens taken from neuropathic areas and from the contralateral side, immunocytochemistry being applied to a pan-neuronal marker, a protein gene-product (PGP 9.5). One of the patients, suffering from compression of the ulnar nerve, had dyshidrotic eczema of the hands that was absent on areas of skin that were neuropathic. The cutaneous innervation (most of which was sensory) was reduced by 50% in the neuropathic area as compared with the contralateral side. The other patient had unilateral pruritus on the parethic side after a stroke. The cutaneous innervation of that side was reduced by 80% as compared with the other side. It seems that peripheral sensory innervation is a prerequisite for inflammation, whereas spontaneous itching may emanate from a central nervous system disorder such as a stroke and continue on in partly denervated skin. (Less)
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keywords
Case Report, Needle, Cerebrovascular Accident/*complications/pathology, Hand Dermatoses/etiology, *Ulnar Nerve, Tomography, X-Ray Computed, Skin/*innervation/pathology, Risk Assessment, Pruritus/*etiology, Prognosis, Peripheral Nervous System Diseases/*complications/pathology, Nerve Fibers/*pathology, Middle Age, Human, Male, Biopsy
in
Journal of American Academy of Dermatology
volume
46
issue
2
pages
215 - 217
publisher
Elsevier
external identifiers
  • wos:000173711200006
  • pmid:11807432
  • scopus:0036164595
ISSN
0190-9622
DOI
10.1067/mjd.2002.118540
language
English
LU publication?
yes
id
6bed898e-ae5a-4dc4-aa43-acee55ec5c25 (old id 106511)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11807432&dopt=Abstract
date added to LUP
2007-07-03 09:25:50
date last changed
2017-01-01 04:34:37
@article{6bed898e-ae5a-4dc4-aa43-acee55ec5c25,
  abstract     = {Two dermatologic patients displaying peripheral and central nerve damage, respectively, are described. Cutaneous nerve fibers in both patients were studied in skin biopsy specimens taken from neuropathic areas and from the contralateral side, immunocytochemistry being applied to a pan-neuronal marker, a protein gene-product (PGP 9.5). One of the patients, suffering from compression of the ulnar nerve, had dyshidrotic eczema of the hands that was absent on areas of skin that were neuropathic. The cutaneous innervation (most of which was sensory) was reduced by 50% in the neuropathic area as compared with the contralateral side. The other patient had unilateral pruritus on the parethic side after a stroke. The cutaneous innervation of that side was reduced by 80% as compared with the other side. It seems that peripheral sensory innervation is a prerequisite for inflammation, whereas spontaneous itching may emanate from a central nervous system disorder such as a stroke and continue on in partly denervated skin.},
  author       = {Wallengren, Joanna and Tegner, Eva and Sundler, Frank},
  issn         = {0190-9622},
  keyword      = {Case Report,Needle,Cerebrovascular Accident/*complications/pathology,Hand Dermatoses/etiology,*Ulnar Nerve,Tomography,X-Ray Computed,Skin/*innervation/pathology,Risk Assessment,Pruritus/*etiology,Prognosis,Peripheral Nervous System Diseases/*complications/pathology,Nerve Fibers/*pathology,Middle Age,Human,Male,Biopsy},
  language     = {eng},
  number       = {2},
  pages        = {215--217},
  publisher    = {Elsevier},
  series       = {Journal of American Academy of Dermatology},
  title        = {Cutaneous sensory nerve fibers are decreased in number after peripheral and central nerve damage.},
  url          = {http://dx.doi.org/10.1067/mjd.2002.118540},
  volume       = {46},
  year         = {2002},
}