Cutaneous sensory nerve fibers are decreased in number after peripheral and central nerve damage.
Wallengren, Joanna LU
; Tegner, Eva
LU
and Sundler, Frank
LU
(2002)
In Journal of American Academy of Dermatology
46(2).
p.215-217
- Abstract
- Two dermatologic patients displaying peripheral and central nerve damage, respectively, are described. Cutaneous nerve fibers in both patients were studied in skin biopsy specimens taken from neuropathic areas and from the contralateral side, immunocytochemistry being applied to a pan-neuronal marker, a protein gene-product (PGP 9.5). One of the patients, suffering from compression of the ulnar nerve, had dyshidrotic eczema of the hands that was absent on areas of skin that were neuropathic. The cutaneous innervation (most of which was sensory) was reduced by 50% in the neuropathic area as compared with the contralateral side. The other patient had unilateral pruritus on the parethic side after a stroke. The cutaneous innervation of that... (More)
- Two dermatologic patients displaying peripheral and central nerve damage, respectively, are described. Cutaneous nerve fibers in both patients were studied in skin biopsy specimens taken from neuropathic areas and from the contralateral side, immunocytochemistry being applied to a pan-neuronal marker, a protein gene-product (PGP 9.5). One of the patients, suffering from compression of the ulnar nerve, had dyshidrotic eczema of the hands that was absent on areas of skin that were neuropathic. The cutaneous innervation (most of which was sensory) was reduced by 50% in the neuropathic area as compared with the contralateral side. The other patient had unilateral pruritus on the parethic side after a stroke. The cutaneous innervation of that side was reduced by 80% as compared with the other side. It seems that peripheral sensory innervation is a prerequisite for inflammation, whereas spontaneous itching may emanate from a central nervous system disorder such as a stroke and continue on in partly denervated skin. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/106511
- author
- Wallengren, Joanna
LU
; Tegner, Eva
LU
and Sundler, Frank
LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Case Report, Needle, Cerebrovascular Accident/*complications/pathology, Hand Dermatoses/etiology, *Ulnar Nerve, Tomography, X-Ray Computed, Skin/*innervation/pathology, Risk Assessment, Pruritus/*etiology, Prognosis, Peripheral Nervous System Diseases/*complications/pathology, Nerve Fibers/*pathology, Middle Age, Human, Male, Biopsy
- in
- Journal of American Academy of Dermatology
- volume
- 46
- issue
- 2
- pages
- 215 - 217
- publisher
- Elsevier
- external identifiers
-
- wos:000173711200006
- pmid:11807432
- scopus:0036164595
- ISSN
- 0190-9622
- DOI
- 10.1067/mjd.2002.118540
- language
- English
- LU publication?
- yes
- id
- 6bed898e-ae5a-4dc4-aa43-acee55ec5c25 (old id 106511)
- alternative location
- http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11807432&dopt=Abstract
- date added to LUP
- 2016-04-01 11:49:25
- date last changed
- 2022-07-29 18:28:54
@article{6bed898e-ae5a-4dc4-aa43-acee55ec5c25,
abstract = {{Two dermatologic patients displaying peripheral and central nerve damage, respectively, are described. Cutaneous nerve fibers in both patients were studied in skin biopsy specimens taken from neuropathic areas and from the contralateral side, immunocytochemistry being applied to a pan-neuronal marker, a protein gene-product (PGP 9.5). One of the patients, suffering from compression of the ulnar nerve, had dyshidrotic eczema of the hands that was absent on areas of skin that were neuropathic. The cutaneous innervation (most of which was sensory) was reduced by 50% in the neuropathic area as compared with the contralateral side. The other patient had unilateral pruritus on the parethic side after a stroke. The cutaneous innervation of that side was reduced by 80% as compared with the other side. It seems that peripheral sensory innervation is a prerequisite for inflammation, whereas spontaneous itching may emanate from a central nervous system disorder such as a stroke and continue on in partly denervated skin.}},
author = {{Wallengren, Joanna and Tegner, Eva and Sundler, Frank}},
issn = {{0190-9622}},
keywords = {{Case Report; Needle; Cerebrovascular Accident/*complications/pathology; Hand Dermatoses/etiology; *Ulnar Nerve; Tomography; X-Ray Computed; Skin/*innervation/pathology; Risk Assessment; Pruritus/*etiology; Prognosis; Peripheral Nervous System Diseases/*complications/pathology; Nerve Fibers/*pathology; Middle Age; Human; Male; Biopsy}},
language = {{eng}},
number = {{2}},
pages = {{215--217}},
publisher = {{Elsevier}},
series = {{Journal of American Academy of Dermatology}},
title = {{Cutaneous sensory nerve fibers are decreased in number after peripheral and central nerve damage.}},
url = {{http://dx.doi.org/10.1067/mjd.2002.118540}},
doi = {{10.1067/mjd.2002.118540}},
volume = {{46}},
year = {{2002}},
}