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Screening for MODY mutations, GAD antibodies, and type 1 diabetes--associated HLA genotypes in women with gestational diabetes mellitus.

Weng, Jianping; Ekelund, Magnus; Lehto, Markku; Li, Haiyan LU ; Ekberg, Göran; Frid, Anders LU ; Åberg, Anders E LU ; Groop, Leif LU and Berntorp, Kerstin LU (2002) In Diabetes Care 25(1). p.68-71
Abstract
OBJECTIVE: To investigate whether genetic susceptibility to type 1 diabetes or maturity-onset diabetes of the young (MODY) increases susceptibility to gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: We studied mutations in MODY1-4 genes, the presence of GAD antibodies, and HLA DQB1 risk genotypes in 66 Swedish women with GDM and a family history of diabetes. An oral glucose tolerance test was repeated in 46 women at 1 year postpartum. RESULTS: There was no increase in type 1 diabetes-associated HLA-DQB1 alleles or GAD antibodies when compared with a group of type 2 diabetic patients (n = 82) or healthy control subjects (n = 86). Mutations in known MODY genes were identified in 3 of the 66 subjects (1 MODY2, 1 MODY3, and 1... (More)
OBJECTIVE: To investigate whether genetic susceptibility to type 1 diabetes or maturity-onset diabetes of the young (MODY) increases susceptibility to gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: We studied mutations in MODY1-4 genes, the presence of GAD antibodies, and HLA DQB1 risk genotypes in 66 Swedish women with GDM and a family history of diabetes. An oral glucose tolerance test was repeated in 46 women at 1 year postpartum. RESULTS: There was no increase in type 1 diabetes-associated HLA-DQB1 alleles or GAD antibodies when compared with a group of type 2 diabetic patients (n = 82) or healthy control subjects (n = 86). Mutations in known MODY genes were identified in 3 of the 66 subjects (1 MODY2, 1 MODY3, and 1 MODY4). Of the 46 GDM subjects, 2 had diabetes (4%) and 17 had impaired glucose tolerance (IGT) (37%) at 1 year postpartum. Of the two subjects who developed manifest diabetes, one carried a MODY3 mutation (A203H in the hepatocyte nuclear factor-1alpha gene). There was no increase in high-risk HLA alleles or GAD antibodies in the women who had manifest diabetes or IGT at 1 year postpartum. CONCLUSIONS: MODY mutations but not autoimmunity contribute to GDM in Swedish women with a family history of diabetes and increase the risk of subsequent diabetes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Diabetes Mellitus Non-Insulin-Dependent : genetics, Diabetes Gestational : genetics : immunology, Female, Support Non-U.S. Gov't, Sweden, Risk Assessment, Pregnancy, Patient Selection, Mutation, Middle Age, Human, HLA Antigens : genetics, HLA-DQ Antigens : genetics, Genotype, Glucose Intolerance : genetics : immunology, Adult, Diabetes Mellitus Insulin-Dependent : genetics : immunology
in
Diabetes Care
volume
25
issue
1
pages
68 - 71
publisher
American Diabetes Association
external identifiers
  • pmid:11772903
  • wos:000173036900012
  • scopus:0036364915
ISSN
1935-5548
DOI
10.2337/diacare.25.1.68
language
English
LU publication?
yes
id
1f69e3ba-4ed3-4f25-887f-8600366afec8 (old id 106886)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11772903&dopt=Abstract
date added to LUP
2007-07-30 10:43:24
date last changed
2017-05-28 04:30:14
@article{1f69e3ba-4ed3-4f25-887f-8600366afec8,
  abstract     = {OBJECTIVE: To investigate whether genetic susceptibility to type 1 diabetes or maturity-onset diabetes of the young (MODY) increases susceptibility to gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: We studied mutations in MODY1-4 genes, the presence of GAD antibodies, and HLA DQB1 risk genotypes in 66 Swedish women with GDM and a family history of diabetes. An oral glucose tolerance test was repeated in 46 women at 1 year postpartum. RESULTS: There was no increase in type 1 diabetes-associated HLA-DQB1 alleles or GAD antibodies when compared with a group of type 2 diabetic patients (n = 82) or healthy control subjects (n = 86). Mutations in known MODY genes were identified in 3 of the 66 subjects (1 MODY2, 1 MODY3, and 1 MODY4). Of the 46 GDM subjects, 2 had diabetes (4%) and 17 had impaired glucose tolerance (IGT) (37%) at 1 year postpartum. Of the two subjects who developed manifest diabetes, one carried a MODY3 mutation (A203H in the hepatocyte nuclear factor-1alpha gene). There was no increase in high-risk HLA alleles or GAD antibodies in the women who had manifest diabetes or IGT at 1 year postpartum. CONCLUSIONS: MODY mutations but not autoimmunity contribute to GDM in Swedish women with a family history of diabetes and increase the risk of subsequent diabetes.},
  author       = {Weng, Jianping and Ekelund, Magnus and Lehto, Markku and Li, Haiyan and Ekberg, Göran and Frid, Anders and Åberg, Anders E and Groop, Leif and Berntorp, Kerstin},
  issn         = {1935-5548},
  keyword      = {Diabetes Mellitus Non-Insulin-Dependent : genetics,Diabetes Gestational : genetics : immunology,Female,Support Non-U.S. Gov't,Sweden,Risk Assessment,Pregnancy,Patient Selection,Mutation,Middle Age,Human,HLA Antigens : genetics,HLA-DQ Antigens : genetics,Genotype,Glucose Intolerance : genetics : immunology,Adult,Diabetes Mellitus Insulin-Dependent : genetics : immunology},
  language     = {eng},
  number       = {1},
  pages        = {68--71},
  publisher    = {American Diabetes Association},
  series       = {Diabetes Care},
  title        = {Screening for MODY mutations, GAD antibodies, and type 1 diabetes--associated HLA genotypes in women with gestational diabetes mellitus.},
  url          = {http://dx.doi.org/10.2337/diacare.25.1.68},
  volume       = {25},
  year         = {2002},
}