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Platelet and leukocyte activation during aortoiliac angiography and angioplasty.

Barani, Jamal LU ; Gottsäter, Anders LU ; Mattiasson, Ingrid LU and Lindblad, Bengt LU (2002) In European Journal of Vascular and Endovascular Surgery 23(3). p.220-225
Abstract
OBJECTIVE: to evaluate platelet and leukocyte activation during aortoiliac angiography and percutaneous transluminal angioplasty (PTA). METHODS: an observational study of 14 patients with aortoiliac atherosclerotic disease, nine of whom underwent PTA. The proportion of fibrinogen-, and P-selectin positive platelets, P-selectin expression on platelets, intraplatelet cGMP and cAMP, CD18 positive granulocytes, CD18 expression on granulocytes, plasma (p)-neopterin, p-TNF alpha and p- interleukin-6 were repeatedly measured in arterial blood during angiography and in venous blood before and after. RESULTS: compared to a previous venous sample, arterial intraplatelet cAMP was increased proximal to the atherosclerotic lesion before contrast... (More)
OBJECTIVE: to evaluate platelet and leukocyte activation during aortoiliac angiography and percutaneous transluminal angioplasty (PTA). METHODS: an observational study of 14 patients with aortoiliac atherosclerotic disease, nine of whom underwent PTA. The proportion of fibrinogen-, and P-selectin positive platelets, P-selectin expression on platelets, intraplatelet cGMP and cAMP, CD18 positive granulocytes, CD18 expression on granulocytes, plasma (p)-neopterin, p-TNF alpha and p- interleukin-6 were repeatedly measured in arterial blood during angiography and in venous blood before and after. RESULTS: compared to a previous venous sample, arterial intraplatelet cAMP was increased proximal to the atherosclerotic lesion before contrast infusion and PTA (median 18 [range: 14-22] vs 16 [15-21] pmol/10(9) platelets p<0.05), and intraplatelet cGMP was increased proximal to the lesion after contrast infusion and PTA (1.2 [0.8-3.9] vs 0.9 [0.6-2.5] pmol/10(9) platelets p<0.05). Four hours after angiography, both the proportion of P-selectin positive platelets (28[11-55]%) and platelet P-selectin expression (9[6-40]) had decreased (p<0.05), from arterial values distal to the lesion before contrast infusion and PTA (57 [24-78]% and 26 [10-83]). Granulocyte CD18 expression was lower during angiography than in a previous venous sample. CONCLUSIONS: the results are compatible with platelet but not leukocyte activation during peripheral angiography. (Less)
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keywords
Iliac Artery : physiopathology, Iliac Artery : radiography, Female, Contrast Media : pharmacology, Arteriosclerosis : therapy, Arteriosclerosis : physiopathology, Aortography, Aorta : physiopathology, Aorta : drug effects, Balloon, Angiography, Angioplasty, 80 and over, Aged, Leukocytes : drug effects, Male, Leukocytes : physiology, Iliac Artery : drug effects, Human, Middle Age, Platelet Activation : drug effects, Platelet Activation : physiology
in
European Journal of Vascular and Endovascular Surgery
volume
23
issue
3
pages
220 - 225
publisher
Elsevier
external identifiers
  • pmid:11914008
  • wos:000175095600006
  • scopus:0036515072
ISSN
1532-2165
DOI
10.1053/ejvs.2001.1594
language
English
LU publication?
yes
id
63fc3fa3-8dc1-4e21-aeaf-d6e247bc2756 (old id 107179)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11914008&dopt=Abstract
date added to LUP
2007-07-11 15:54:56
date last changed
2017-01-01 06:53:05
@article{63fc3fa3-8dc1-4e21-aeaf-d6e247bc2756,
  abstract     = {OBJECTIVE: to evaluate platelet and leukocyte activation during aortoiliac angiography and percutaneous transluminal angioplasty (PTA). METHODS: an observational study of 14 patients with aortoiliac atherosclerotic disease, nine of whom underwent PTA. The proportion of fibrinogen-, and P-selectin positive platelets, P-selectin expression on platelets, intraplatelet cGMP and cAMP, CD18 positive granulocytes, CD18 expression on granulocytes, plasma (p)-neopterin, p-TNF alpha and p- interleukin-6 were repeatedly measured in arterial blood during angiography and in venous blood before and after. RESULTS: compared to a previous venous sample, arterial intraplatelet cAMP was increased proximal to the atherosclerotic lesion before contrast infusion and PTA (median 18 [range: 14-22] vs 16 [15-21] pmol/10(9) platelets p&lt;0.05), and intraplatelet cGMP was increased proximal to the lesion after contrast infusion and PTA (1.2 [0.8-3.9] vs 0.9 [0.6-2.5] pmol/10(9) platelets p&lt;0.05). Four hours after angiography, both the proportion of P-selectin positive platelets (28[11-55]%) and platelet P-selectin expression (9[6-40]) had decreased (p&lt;0.05), from arterial values distal to the lesion before contrast infusion and PTA (57 [24-78]% and 26 [10-83]). Granulocyte CD18 expression was lower during angiography than in a previous venous sample. CONCLUSIONS: the results are compatible with platelet but not leukocyte activation during peripheral angiography.},
  author       = {Barani, Jamal and Gottsäter, Anders and Mattiasson, Ingrid and Lindblad, Bengt},
  issn         = {1532-2165},
  keyword      = {Iliac Artery : physiopathology,Iliac Artery : radiography,Female,Contrast Media : pharmacology,Arteriosclerosis : therapy,Arteriosclerosis : physiopathology,Aortography,Aorta : physiopathology,Aorta : drug effects,Balloon,Angiography,Angioplasty,80 and over,Aged,Leukocytes : drug effects,Male,Leukocytes : physiology,Iliac Artery : drug effects,Human,Middle Age,Platelet Activation : drug effects,Platelet Activation : physiology},
  language     = {eng},
  number       = {3},
  pages        = {220--225},
  publisher    = {Elsevier},
  series       = {European Journal of Vascular and Endovascular Surgery},
  title        = {Platelet and leukocyte activation during aortoiliac angiography and angioplasty.},
  url          = {http://dx.doi.org/10.1053/ejvs.2001.1594},
  volume       = {23},
  year         = {2002},
}