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Uncoupling proteins--a new family of proteins with unknown function.

Erlanson-Albertsson, Charlotte LU (2002) In Nutritional Neuroscience 5(1). p.1-11
Abstract
Uncoupling proteins are inner mitochondrial membrane proteins, which dissipate the proton gradient, releasing the stored energy as heat. Five proteins have been cloned, named UCP1, UCP2, UCP3, UCP4 and UCP5/BMCP1. These proteins are structurally related but differ in tissue expression. UCP1 is expressed uniquely in the brown adipose tissue, while UCP2 is widely distributed, UCP3 is mainly restricted to skeletal muscle and UCP4 and UCP5/BMCP1 expressed in the brain. The properties and regulation of the uncoupling proteins and their exact function has been the focus of an intense research during recent years. This review briefly summarizes the actual knowledge of the properties and function of this new family of proteins. While UCP1 has a... (More)
Uncoupling proteins are inner mitochondrial membrane proteins, which dissipate the proton gradient, releasing the stored energy as heat. Five proteins have been cloned, named UCP1, UCP2, UCP3, UCP4 and UCP5/BMCP1. These proteins are structurally related but differ in tissue expression. UCP1 is expressed uniquely in the brown adipose tissue, while UCP2 is widely distributed, UCP3 is mainly restricted to skeletal muscle and UCP4 and UCP5/BMCP1 expressed in the brain. The properties and regulation of the uncoupling proteins and their exact function has been the focus of an intense research during recent years. This review briefly summarizes the actual knowledge of the properties and function of this new family of proteins. While UCP1 has a clear role in energy homeostasis, the newcomers UCP2-UCP5 may have more delicate physiological importance acting as free radical oxygen scavengers and in the regulation of ATP-dependent processes, such as secretion. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Free Oxygen Radical, Thermogenesis, Energy, Mitochondria, Obesity, Atp
in
Nutritional Neuroscience
volume
5
issue
1
pages
1 - 11
publisher
Taylor & Francis
external identifiers
  • pmid:11929192
  • wos:000176217600001
  • scopus:0036118511
ISSN
1476-8305
DOI
10.1080/10284150290007038
language
English
LU publication?
yes
id
b5fbe0d0-3684-4b63-9ec1-a3f2086ea4de (old id 107359)
date added to LUP
2007-07-12 09:00:04
date last changed
2017-02-26 03:34:44
@article{b5fbe0d0-3684-4b63-9ec1-a3f2086ea4de,
  abstract     = {Uncoupling proteins are inner mitochondrial membrane proteins, which dissipate the proton gradient, releasing the stored energy as heat. Five proteins have been cloned, named UCP1, UCP2, UCP3, UCP4 and UCP5/BMCP1. These proteins are structurally related but differ in tissue expression. UCP1 is expressed uniquely in the brown adipose tissue, while UCP2 is widely distributed, UCP3 is mainly restricted to skeletal muscle and UCP4 and UCP5/BMCP1 expressed in the brain. The properties and regulation of the uncoupling proteins and their exact function has been the focus of an intense research during recent years. This review briefly summarizes the actual knowledge of the properties and function of this new family of proteins. While UCP1 has a clear role in energy homeostasis, the newcomers UCP2-UCP5 may have more delicate physiological importance acting as free radical oxygen scavengers and in the regulation of ATP-dependent processes, such as secretion.},
  author       = {Erlanson-Albertsson, Charlotte},
  issn         = {1476-8305},
  keyword      = {Free Oxygen Radical,Thermogenesis,Energy,Mitochondria,Obesity,Atp},
  language     = {eng},
  number       = {1},
  pages        = {1--11},
  publisher    = {Taylor & Francis},
  series       = {Nutritional Neuroscience},
  title        = {Uncoupling proteins--a new family of proteins with unknown function.},
  url          = {http://dx.doi.org/10.1080/10284150290007038},
  volume       = {5},
  year         = {2002},
}