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Predictive factors of developing diabetes mellitus in women with gestational diabetes.

Åberg, Anders E LU ; Jönsson, Eva LU ; Eskilsson, Inger; Landin-Olsson, Mona LU and Frid, Anders LU (2002) In Acta Obstetricia et Gynecologica Scandinavica 81(1). p.11-16
Abstract
BACKGROUND: To investigate which factors during gestational diabetes pregnancies correlate with the risk of developing impaired glucose tolerance or diabetes 1 year postpartum and to compare this risk in women with gestational diabetes and women with a normal oral glucose tolerance test during pregnancy. METHODS: Of 315 women with gestational diabetes, defined as a 2-hr blood glucose value of at least 9.0 mmol/l at a 75-g oral glucose tolerance test, who delivered in Lund 1991-99, 229 (73%) performed a new test 1 year postpartum. We compared maternal and fetal factors during pregnancy with the test value at follow up. A control group of 153 women with a 2-hr test value below 7.8 mmol/l during pregnancy were invited to a new test 1 year... (More)
BACKGROUND: To investigate which factors during gestational diabetes pregnancies correlate with the risk of developing impaired glucose tolerance or diabetes 1 year postpartum and to compare this risk in women with gestational diabetes and women with a normal oral glucose tolerance test during pregnancy. METHODS: Of 315 women with gestational diabetes, defined as a 2-hr blood glucose value of at least 9.0 mmol/l at a 75-g oral glucose tolerance test, who delivered in Lund 1991-99, 229 (73%) performed a new test 1 year postpartum. We compared maternal and fetal factors during pregnancy with the test value at follow up. A control group of 153 women with a 2-hr test value below 7.8 mmol/l during pregnancy were invited to a new test 1 year postpartum and 60 (39%) accepted. RESULTS: At 1 year follow up, 31% of the women with gestational diabetes but only one of the 60 controls showed pathologic glucose tolerance and one had developed diabetes. The following factors in women with gestational diabetes were identified as predicting impaired glucose tolerance or diabetes at 1 year follow up: maternal age over 40 and--in a multiple regression analysis, independent of each other--a high 2-hr value at oral glucose tolerance test during pregnancy and insulin treatment during pregnancy. CONCLUSION: The risk of developing manifest diabetes after gestational diabetes may be high enough to justify a general screening or diagnostic procedure in all pregnant women to identify women with gestational diabetes and a postpartum follow up program for them. This study did not identify any particular factor during pregnancy with enough precision to predict a later progression to diabetes. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
keywords
Non-Insulin-Dependent : epidemiology, Diabetes, Gestational : epidemiology, Risk Assessment, Regression Analysis, Puerperium, Pregnancy, Maternal Age 35 and over, Human, Glucose Tolerance Test, Female, Follow-Up Studies, Diabetes Mellitus, Adult, Case-Control Studies
in
Acta Obstetricia et Gynecologica Scandinavica
volume
81
issue
1
pages
11 - 16
publisher
Wiley-Blackwell
external identifiers
  • wos:000174398000003
  • pmid:11942881
  • scopus:0036192305
ISSN
1600-0412
DOI
10.1046/j.0001-6349.2001.00000.x
language
English
LU publication?
yes
id
74f5e9ca-f510-4981-b5b2-6998ea5e613b (old id 107520)
date added to LUP
2007-07-17 15:43:13
date last changed
2017-08-20 04:19:31
@article{74f5e9ca-f510-4981-b5b2-6998ea5e613b,
  abstract     = {BACKGROUND: To investigate which factors during gestational diabetes pregnancies correlate with the risk of developing impaired glucose tolerance or diabetes 1 year postpartum and to compare this risk in women with gestational diabetes and women with a normal oral glucose tolerance test during pregnancy. METHODS: Of 315 women with gestational diabetes, defined as a 2-hr blood glucose value of at least 9.0 mmol/l at a 75-g oral glucose tolerance test, who delivered in Lund 1991-99, 229 (73%) performed a new test 1 year postpartum. We compared maternal and fetal factors during pregnancy with the test value at follow up. A control group of 153 women with a 2-hr test value below 7.8 mmol/l during pregnancy were invited to a new test 1 year postpartum and 60 (39%) accepted. RESULTS: At 1 year follow up, 31% of the women with gestational diabetes but only one of the 60 controls showed pathologic glucose tolerance and one had developed diabetes. The following factors in women with gestational diabetes were identified as predicting impaired glucose tolerance or diabetes at 1 year follow up: maternal age over 40 and--in a multiple regression analysis, independent of each other--a high 2-hr value at oral glucose tolerance test during pregnancy and insulin treatment during pregnancy. CONCLUSION: The risk of developing manifest diabetes after gestational diabetes may be high enough to justify a general screening or diagnostic procedure in all pregnant women to identify women with gestational diabetes and a postpartum follow up program for them. This study did not identify any particular factor during pregnancy with enough precision to predict a later progression to diabetes.},
  author       = {Åberg, Anders E and Jönsson, Eva and Eskilsson, Inger and Landin-Olsson, Mona and Frid, Anders},
  issn         = {1600-0412},
  keyword      = {Non-Insulin-Dependent : epidemiology,Diabetes,Gestational : epidemiology,Risk Assessment,Regression Analysis,Puerperium,Pregnancy,Maternal Age 35 and over,Human,Glucose Tolerance Test,Female,Follow-Up Studies,Diabetes Mellitus,Adult,Case-Control Studies},
  language     = {eng},
  number       = {1},
  pages        = {11--16},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Obstetricia et Gynecologica Scandinavica},
  title        = {Predictive factors of developing diabetes mellitus in women with gestational diabetes.},
  url          = {http://dx.doi.org/10.1046/j.0001-6349.2001.00000.x},
  volume       = {81},
  year         = {2002},
}