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Percutaneous fine-needle aspiration cytology in the diagnosis and management of liver tumours.

Ohlsson, Bodil LU ; Nilsson, J; Stenram, Unne LU ; Åkerman, Måns LU and Tranberg, Karl-Göran LU (2002) In British Journal of Surgery 89(6). p.757-762
Abstract
BACKGROUND: The aim of the study was to investigate the value of percutaneous fine-needle aspiration cytology (FNAC) in the diagnosis and management of liver tumours. METHODS: FNAC followed by histopathological examination was carried out in 216 patients with suspected liver tumours. The final diagnosis was primary liver cancer in 106, colorectal metastases in 51, non-colorectal metastases in 46, benign tumour in nine and no tumour in four patients. RESULTS: Cytology resulted in correct classification of the lesion as benign or malignant in 87 per cent of patients, correct discrimination between primary and secondary malignancy in half of the patients, and a correct diagnosis of tumour type in one-third of patients. The tumour was... (More)
BACKGROUND: The aim of the study was to investigate the value of percutaneous fine-needle aspiration cytology (FNAC) in the diagnosis and management of liver tumours. METHODS: FNAC followed by histopathological examination was carried out in 216 patients with suspected liver tumours. The final diagnosis was primary liver cancer in 106, colorectal metastases in 51, non-colorectal metastases in 46, benign tumour in nine and no tumour in four patients. RESULTS: Cytology resulted in correct classification of the lesion as benign or malignant in 87 per cent of patients, correct discrimination between primary and secondary malignancy in half of the patients, and a correct diagnosis of tumour type in one-third of patients. The tumour was erroneously classified as benign or malignant in 22 patients (11 per cent) and four patients (2 per cent) respectively. When FNAC showed malignancy, the predictive value was 98 per cent, whereas the predictive value was 27 per cent when it did not. FNAC guided investigations and treatment in one-quarter of patients. Implantation metastases were recorded in seven patients (3 per cent), including five (10 per cent) of 51 patients with colorectal liver metastases, and caused major local problems and death in four patients. CONCLUSION: FNAC was valuable in about a quarter of patients with liver tumour. The risks of implantation metastases and a false-negative finding do not justify its use in candidates for curative therapy of liver tumours. (Less)
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organization
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Contribution to journal
publication status
published
subject
keywords
Male, Liver Neoplasms : pathology, Liver : pathology, Human, Female, Colorectal Neoplasms, Needle : standards, Biopsy, Needle : methods, Needle : adverse effects, 80 and over, Aged, Sensitivity and Specificity, Middle Age, Patient Education, Retrospective Studies, Adult
in
British Journal of Surgery
volume
89
issue
6
pages
757 - 762
publisher
John Wiley & Sons
external identifiers
  • wos:000175839900014
  • pmid:12027987
  • scopus:0036268403
ISSN
1365-2168
DOI
10.1046/j.1365-2168.2002.02111.x
language
English
LU publication?
yes
id
e6b564cf-ec02-4a53-bf4a-befc7b104b78 (old id 108529)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12027987&dopt=Abstract
date added to LUP
2007-07-20 12:03:50
date last changed
2017-05-21 03:38:16
@article{e6b564cf-ec02-4a53-bf4a-befc7b104b78,
  abstract     = {BACKGROUND: The aim of the study was to investigate the value of percutaneous fine-needle aspiration cytology (FNAC) in the diagnosis and management of liver tumours. METHODS: FNAC followed by histopathological examination was carried out in 216 patients with suspected liver tumours. The final diagnosis was primary liver cancer in 106, colorectal metastases in 51, non-colorectal metastases in 46, benign tumour in nine and no tumour in four patients. RESULTS: Cytology resulted in correct classification of the lesion as benign or malignant in 87 per cent of patients, correct discrimination between primary and secondary malignancy in half of the patients, and a correct diagnosis of tumour type in one-third of patients. The tumour was erroneously classified as benign or malignant in 22 patients (11 per cent) and four patients (2 per cent) respectively. When FNAC showed malignancy, the predictive value was 98 per cent, whereas the predictive value was 27 per cent when it did not. FNAC guided investigations and treatment in one-quarter of patients. Implantation metastases were recorded in seven patients (3 per cent), including five (10 per cent) of 51 patients with colorectal liver metastases, and caused major local problems and death in four patients. CONCLUSION: FNAC was valuable in about a quarter of patients with liver tumour. The risks of implantation metastases and a false-negative finding do not justify its use in candidates for curative therapy of liver tumours.},
  author       = {Ohlsson, Bodil and Nilsson, J and Stenram, Unne and Åkerman, Måns and Tranberg, Karl-Göran},
  issn         = {1365-2168},
  keyword      = {Male,Liver Neoplasms : pathology,Liver : pathology,Human,Female,Colorectal Neoplasms,Needle : standards,Biopsy,Needle : methods,Needle : adverse effects,80 and over,Aged,Sensitivity and Specificity,Middle Age,Patient Education,Retrospective Studies,Adult},
  language     = {eng},
  number       = {6},
  pages        = {757--762},
  publisher    = {John Wiley & Sons},
  series       = {British Journal of Surgery},
  title        = {Percutaneous fine-needle aspiration cytology in the diagnosis and management of liver tumours.},
  url          = {http://dx.doi.org/10.1046/j.1365-2168.2002.02111.x},
  volume       = {89},
  year         = {2002},
}