Systemic interleukin-6 response to colorectal surgery originates from the bowel.
(2002) In Digestive Surgery 19(3). p.210-215- Abstract
- Background: Surgical trauma evokes a systemic cytokine response which is enhanced in patients with colorectal cancer. The aim of this study was to locate the origin of the systemic cytokine response to colorectal surgery. Methods: The concentrations of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) were analysed in systemic and mesenteric venous blood in 12 patients operated on with colorectal resections due to cancer or benign lesions. Immunohistochemical staining and analysis of tissue concentrations of IL-6 and TNF-alpha in homogenates from tumours and benign specimens were performed. Results: Mesenteric venous blood contained higher concentrations of IL-6 compared to systemic venous blood after resection, but not... (More)
- Background: Surgical trauma evokes a systemic cytokine response which is enhanced in patients with colorectal cancer. The aim of this study was to locate the origin of the systemic cytokine response to colorectal surgery. Methods: The concentrations of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) were analysed in systemic and mesenteric venous blood in 12 patients operated on with colorectal resections due to cancer or benign lesions. Immunohistochemical staining and analysis of tissue concentrations of IL-6 and TNF-alpha in homogenates from tumours and benign specimens were performed. Results: Mesenteric venous blood contained higher concentrations of IL-6 compared to systemic venous blood after resection, but not before. Tissue concentration of IL-6 was higher in the tumours compared to the benign specimens and immunohistochemistry revealed an abundance of IL-6 and TNF-alpha in malignant epithelium compared to benign mucosa. Conclusion: The higher concentration of IL-6 in venous blood from the mesenterium of the resected colonic segment compared to systemic levels, indicates that the bowel is the source of the IL-6 response to surgical trauma in colorectal surgery. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/109348
- author
- Syk, Ingvar LU ; Mangell, Peter LU ; Bjartell, Anders LU and Jeppsson, Bengt LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Digestive Surgery
- volume
- 19
- issue
- 3
- pages
- 210 - 215
- publisher
- Karger
- external identifiers
-
- pmid:12119524
- wos:000176985500011
- scopus:0036062149
- ISSN
- 0253-4886
- DOI
- 10.1159/000064215
- language
- English
- LU publication?
- yes
- id
- 3039e097-0a10-407a-bbb0-1f49feb94b52 (old id 109348)
- date added to LUP
- 2016-04-01 12:33:51
- date last changed
- 2022-01-27 06:49:36
@article{3039e097-0a10-407a-bbb0-1f49feb94b52, abstract = {{Background: Surgical trauma evokes a systemic cytokine response which is enhanced in patients with colorectal cancer. The aim of this study was to locate the origin of the systemic cytokine response to colorectal surgery. Methods: The concentrations of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) were analysed in systemic and mesenteric venous blood in 12 patients operated on with colorectal resections due to cancer or benign lesions. Immunohistochemical staining and analysis of tissue concentrations of IL-6 and TNF-alpha in homogenates from tumours and benign specimens were performed. Results: Mesenteric venous blood contained higher concentrations of IL-6 compared to systemic venous blood after resection, but not before. Tissue concentration of IL-6 was higher in the tumours compared to the benign specimens and immunohistochemistry revealed an abundance of IL-6 and TNF-alpha in malignant epithelium compared to benign mucosa. Conclusion: The higher concentration of IL-6 in venous blood from the mesenterium of the resected colonic segment compared to systemic levels, indicates that the bowel is the source of the IL-6 response to surgical trauma in colorectal surgery.}}, author = {{Syk, Ingvar and Mangell, Peter and Bjartell, Anders and Jeppsson, Bengt}}, issn = {{0253-4886}}, language = {{eng}}, number = {{3}}, pages = {{210--215}}, publisher = {{Karger}}, series = {{Digestive Surgery}}, title = {{Systemic interleukin-6 response to colorectal surgery originates from the bowel.}}, url = {{http://dx.doi.org/10.1159/000064215}}, doi = {{10.1159/000064215}}, volume = {{19}}, year = {{2002}}, }