Evaluation of gastric acid secretion at endoscopy with a modified Congo red test.
(2002) In Gastrointestinal Endoscopy 56(2). p.254-259- Abstract
- BACKGROUND: Markedly decreased or absent gastric acid production is associated with a number of clinically significant conditions, and identification of patients with hypo/achlorhydria may be important. However, current methods of assessing impaired acid secretion are unreliable, time-consuming, and/or complex. The aim of this prospective study was to evaluate a modified endoscopic Congo red test for the diagnosis of hypo/achlorhydria by correlation with a standard gastric acid secretory test. METHODS: One hundred six consecutive outpatients with or without dyspeptic symptoms referred for endoscopy were evaluated by using a modified endoscopic Congo red test and a standard test of gastric acid secretion. The modified endoscopic Congo red... (More)
- BACKGROUND: Markedly decreased or absent gastric acid production is associated with a number of clinically significant conditions, and identification of patients with hypo/achlorhydria may be important. However, current methods of assessing impaired acid secretion are unreliable, time-consuming, and/or complex. The aim of this prospective study was to evaluate a modified endoscopic Congo red test for the diagnosis of hypo/achlorhydria by correlation with a standard gastric acid secretory test. METHODS: One hundred six consecutive outpatients with or without dyspeptic symptoms referred for endoscopy were evaluated by using a modified endoscopic Congo red test and a standard test of gastric acid secretion. The modified endoscopic Congo red test suggested hypo/achlorhydria when there was no color shift or a shift of small extent (less than one third of fundic mucosa). Hypo/achlorhydria by the standard gastric acid secretory test was defined as a maximal acid output of less than 6.9 mmol/hour in men and 5.0 mmol/hour in women. RESULTS: The accuracy of the modified endoscopic Congo red test for the diagnosis of hypo/achlorhydria was 0.98 (95% CI [0.93, 0.99]). The sensitivity was 1.0 (95% CI [0.92, 1.00]) and specificity 0.96 (95% CI [0.88, 0.99]). All patients tolerated the modified endoscopic Congo red test well. CONCLUSION: The modified endoscopic Congo red is an accurate, simple, fast, inexpensive, and well-tolerated chromoendoscopic method for identification of patients with hypo/achlorhydria during routine upper endoscopy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/109655
- author
- Toth, Ervin LU ; Sjölund, Kristina LU ; Thorsson, Ola LU and Thorlacius, Henrik LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Gastrointestinal Endoscopy
- volume
- 56
- issue
- 2
- pages
- 254 - 259
- publisher
- Elsevier
- external identifiers
-
- wos:000177264500016
- scopus:0036673561
- ISSN
- 1097-6779
- DOI
- 10.1067/mge.2002.126134
- language
- English
- LU publication?
- yes
- id
- 223ebc0d-9ce2-4874-944b-dbbe7a9a291f (old id 109655)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12145606&dopt=Abstract
- date added to LUP
- 2016-04-01 16:37:26
- date last changed
- 2024-01-11 11:36:45
@article{223ebc0d-9ce2-4874-944b-dbbe7a9a291f, abstract = {{BACKGROUND: Markedly decreased or absent gastric acid production is associated with a number of clinically significant conditions, and identification of patients with hypo/achlorhydria may be important. However, current methods of assessing impaired acid secretion are unreliable, time-consuming, and/or complex. The aim of this prospective study was to evaluate a modified endoscopic Congo red test for the diagnosis of hypo/achlorhydria by correlation with a standard gastric acid secretory test. METHODS: One hundred six consecutive outpatients with or without dyspeptic symptoms referred for endoscopy were evaluated by using a modified endoscopic Congo red test and a standard test of gastric acid secretion. The modified endoscopic Congo red test suggested hypo/achlorhydria when there was no color shift or a shift of small extent (less than one third of fundic mucosa). Hypo/achlorhydria by the standard gastric acid secretory test was defined as a maximal acid output of less than 6.9 mmol/hour in men and 5.0 mmol/hour in women. RESULTS: The accuracy of the modified endoscopic Congo red test for the diagnosis of hypo/achlorhydria was 0.98 (95% CI [0.93, 0.99]). The sensitivity was 1.0 (95% CI [0.92, 1.00]) and specificity 0.96 (95% CI [0.88, 0.99]). All patients tolerated the modified endoscopic Congo red test well. CONCLUSION: The modified endoscopic Congo red is an accurate, simple, fast, inexpensive, and well-tolerated chromoendoscopic method for identification of patients with hypo/achlorhydria during routine upper endoscopy.}}, author = {{Toth, Ervin and Sjölund, Kristina and Thorsson, Ola and Thorlacius, Henrik}}, issn = {{1097-6779}}, language = {{eng}}, number = {{2}}, pages = {{254--259}}, publisher = {{Elsevier}}, series = {{Gastrointestinal Endoscopy}}, title = {{Evaluation of gastric acid secretion at endoscopy with a modified Congo red test.}}, url = {{http://dx.doi.org/10.1067/mge.2002.126134}}, doi = {{10.1067/mge.2002.126134}}, volume = {{56}}, year = {{2002}}, }