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Regional cerebral blood flow in conscious stroke-prone spontaneously hypertensive rats

Fredriksson, K; Ingvar, M and Johansson, Barbro LU (1984) In Journal of Cerebral Blood Flow and Metabolism 4(1). p.103-106
Abstract
Regional cerebral blood flow (rCBF) was measured autoradiographically with [14C]iodoantipyrine as a diffusible tracer in two strains of conscious normotensive rats (Wistar Kyoto and local Wistar) and in two groups of spontaneously hypertensive stroke-prone rats (SHRSP) with a mean arterial pressure (MAP) below or above 200 mm Hg. In spite of the large differences in arterial pressure, rCBF did not differ significantly between the hypertensive and the normotensive groups in any of the 14 specified brain structures measured. However, rCBF increased asymmetrically within part of the caudate-putamen in two of nine SHRSP with a MAP above 200 mm Hg, indicating a regional drop in the elevated cerebrovascular resistance.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Cerebral Blood Flow and Metabolism
volume
4
issue
1
pages
103 - 106
publisher
Nature Publishing Group
external identifiers
  • pmid:6420425
  • scopus:0021367083
ISSN
1559-7016
language
English
LU publication?
yes
id
a9605b42-1ad7-448c-b489-bfeac9b42587 (old id 1103281)
date added to LUP
2008-08-12 15:48:35
date last changed
2017-01-01 07:17:29
@article{a9605b42-1ad7-448c-b489-bfeac9b42587,
  abstract     = {Regional cerebral blood flow (rCBF) was measured autoradiographically with [14C]iodoantipyrine as a diffusible tracer in two strains of conscious normotensive rats (Wistar Kyoto and local Wistar) and in two groups of spontaneously hypertensive stroke-prone rats (SHRSP) with a mean arterial pressure (MAP) below or above 200 mm Hg. In spite of the large differences in arterial pressure, rCBF did not differ significantly between the hypertensive and the normotensive groups in any of the 14 specified brain structures measured. However, rCBF increased asymmetrically within part of the caudate-putamen in two of nine SHRSP with a MAP above 200 mm Hg, indicating a regional drop in the elevated cerebrovascular resistance.},
  author       = {Fredriksson, K and Ingvar, M and Johansson, Barbro},
  issn         = {1559-7016},
  language     = {eng},
  number       = {1},
  pages        = {103--106},
  publisher    = {Nature Publishing Group},
  series       = {Journal of Cerebral Blood Flow and Metabolism},
  title        = {Regional cerebral blood flow in conscious stroke-prone spontaneously hypertensive rats},
  volume       = {4},
  year         = {1984},
}