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Reciprocal translocation (11;19)(q23;p13) in congenital acute lymphoblastic leukemia

Heim, Sverre LU ; Kristoffersson, Ulf LU ; Mandahl, Nils LU ; Mitelman, Felix LU ; Békássy, Albert LU ; Garwicz, Stanislaw LU ; Heldrup, Jesper LU and Wiebe, Thomas LU (1986) In Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00 23(3). p.239-244
Abstract
The cytogenetic, clinical, and immunologic findings ina 4-month-old girl with acute lymphoblastic leukemia (ALL) are reported. The malignant lymphoblasts were characterized cytogenetically by the reciprocal translocation t(11;19)(q23;p13); immunologically by an immature pre-B-ALL phenotype. In spite of the high-risk nature of the leukemia, the patient attained complete remission relatively quickly and is still free of disease 3 years after diagnosis. Because the only two previously reported ALL patients with t(11;19) also seem to have responded well to therapy, this cytogenetic abnormality might turn out to be an indicator of favorable prognosis in ALL.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00
volume
23
issue
3
pages
239 - 244
publisher
Elsevier
external identifiers
  • pmid:3464343
  • scopus:0023009892
ISSN
0165-4608
DOI
10.1016/0165-4608(86)90183-4
language
English
LU publication?
yes
id
efb404cf-0676-41a0-9947-7466dabcdd72 (old id 1103513)
date added to LUP
2008-08-11 08:50:50
date last changed
2017-01-01 07:10:14
@article{efb404cf-0676-41a0-9947-7466dabcdd72,
  abstract     = {The cytogenetic, clinical, and immunologic findings ina 4-month-old girl with acute lymphoblastic leukemia (ALL) are reported. The malignant lymphoblasts were characterized cytogenetically by the reciprocal translocation t(11;19)(q23;p13); immunologically by an immature pre-B-ALL phenotype. In spite of the high-risk nature of the leukemia, the patient attained complete remission relatively quickly and is still free of disease 3 years after diagnosis. Because the only two previously reported ALL patients with t(11;19) also seem to have responded well to therapy, this cytogenetic abnormality might turn out to be an indicator of favorable prognosis in ALL.},
  author       = {Heim, Sverre and Kristoffersson, Ulf and Mandahl, Nils and Mitelman, Felix and Békássy, Albert and Garwicz, Stanislaw and Heldrup, Jesper and Wiebe, Thomas},
  issn         = {0165-4608},
  language     = {eng},
  number       = {3},
  pages        = {239--244},
  publisher    = {Elsevier},
  series       = {Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00},
  title        = {Reciprocal translocation (11;19)(q23;p13) in congenital acute lymphoblastic leukemia},
  url          = {http://dx.doi.org/10.1016/0165-4608(86)90183-4},
  volume       = {23},
  year         = {1986},
}