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High resolution banding analysis of the reciprocal translocation t(6;9) in acute nonlymphocytic leukemia

Heim, Sverre LU ; Kristoffersson, Ulf LU ; Mandahl, Nils LU ; Mitelman, Felix LU ; Békássy, Albert LU ; Garwicz, Stanislaw LU and Wiebe, Thomas LU (1986) In Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00 22(3). p.195-201
Abstract
The cytogenetic, hematologic, and clinical characteristics of a 13-year-old girl with acquired t(6;9)(p23;q34) and dysmyelopoietic syndrome developing into acute myelomonocytic leukemia are described, bringing the total number of patients with t(6;9) and hematologic disease described in the literature up to 19. The diagnosis has been acute myeloid leukemia in the great majority of these patients; only four have had acute myelomonocytic leukemia. High resolution analysis at the 550 band stage localized the breakpoints in chromosomes #6 and #9 to p23 and 9q34.3, respectively. Previous investigations employing high resolution cytogenetics have mapped the typical 9q breakage site in chronic myeloid leukemia to 9q34.1. In situ hybridization... (More)
The cytogenetic, hematologic, and clinical characteristics of a 13-year-old girl with acquired t(6;9)(p23;q34) and dysmyelopoietic syndrome developing into acute myelomonocytic leukemia are described, bringing the total number of patients with t(6;9) and hematologic disease described in the literature up to 19. The diagnosis has been acute myeloid leukemia in the great majority of these patients; only four have had acute myelomonocytic leukemia. High resolution analysis at the 550 band stage localized the breakpoints in chromosomes #6 and #9 to p23 and 9q34.3, respectively. Previous investigations employing high resolution cytogenetics have mapped the typical 9q breakage site in chronic myeloid leukemia to 9q34.1. In situ hybridization studies have demonstrated that the cellular oncogene c-abl remains on the derivative 9q+ chromosome in t(6;9), whereas it is moved to the Ph marker in t(9;22). Thus, the combined data indicate that c-abl is located between 9q34.1 and 9q34.3, i.e., in subband 9q34.2 or its immediate vicinity. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00
volume
22
issue
3
pages
195 - 201
publisher
Elsevier
external identifiers
  • pmid:3458523
  • scopus:0022445714
ISSN
0165-4608
DOI
10.1016/0165-4608(86)90155-X
language
English
LU publication?
yes
id
e83cda81-fb53-4b63-b4b7-9da8bbbc48f7 (old id 1103521)
date added to LUP
2008-08-11 08:53:13
date last changed
2017-08-06 04:34:00
@article{e83cda81-fb53-4b63-b4b7-9da8bbbc48f7,
  abstract     = {The cytogenetic, hematologic, and clinical characteristics of a 13-year-old girl with acquired t(6;9)(p23;q34) and dysmyelopoietic syndrome developing into acute myelomonocytic leukemia are described, bringing the total number of patients with t(6;9) and hematologic disease described in the literature up to 19. The diagnosis has been acute myeloid leukemia in the great majority of these patients; only four have had acute myelomonocytic leukemia. High resolution analysis at the 550 band stage localized the breakpoints in chromosomes #6 and #9 to p23 and 9q34.3, respectively. Previous investigations employing high resolution cytogenetics have mapped the typical 9q breakage site in chronic myeloid leukemia to 9q34.1. In situ hybridization studies have demonstrated that the cellular oncogene c-abl remains on the derivative 9q+ chromosome in t(6;9), whereas it is moved to the Ph marker in t(9;22). Thus, the combined data indicate that c-abl is located between 9q34.1 and 9q34.3, i.e., in subband 9q34.2 or its immediate vicinity.},
  author       = {Heim, Sverre and Kristoffersson, Ulf and Mandahl, Nils and Mitelman, Felix and Békássy, Albert and Garwicz, Stanislaw and Wiebe, Thomas},
  issn         = {0165-4608},
  language     = {eng},
  number       = {3},
  pages        = {195--201},
  publisher    = {Elsevier},
  series       = {Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00},
  title        = {High resolution banding analysis of the reciprocal translocation t(6;9) in acute nonlymphocytic leukemia},
  url          = {http://dx.doi.org/10.1016/0165-4608(86)90155-X},
  volume       = {22},
  year         = {1986},
}