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A new specific chromosomal rearrangement, t(8;16) (p11;p13), in acute monocytic leukaemia

Heim, Sverre LU ; Avanzi, Gian-Carlo; Billström, Rolf; Kristoffersson, Ulf LU ; Mandahl, Nils LU ; Békássy, Albert LU ; Garwicz, Stanislaw LU ; Wiebe, Thomas LU ; Pegoraro, Loigi and Falda, Michele, et al. (1987) In British Journal of Haematology 66(3). p.323-326
Abstract
The translocation t(8;16) (p11;p13) was found as the sole deviation from the normal karyotype in three patients with acute monocytic leukaemia. The bone marrow morphology was strikingly similar in the two cases where smears were available for re-evaluation: the leukaemic cells showed signs of differentiation, and active erythrophagocytosis was a particularly conspicuous feature. We suggest that t(8;16) (p11;p13) represents a new consistent abnormality in acute monocytic leukaemia, specifically associated with the differentiated subtype (M5b) and with pronounced phagocytic activity by the leukaemic monocytes.
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type
Contribution to journal
publication status
published
subject
in
British Journal of Haematology
volume
66
issue
3
pages
323 - 326
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • pmid:3476150
  • scopus:0023245048
ISSN
0007-1048
DOI
10.1111/j.1365-2141.1987.00323.x
language
English
LU publication?
yes
id
344243c6-7f09-4638-aa90-13260340e66b (old id 1103751)
date added to LUP
2008-08-08 12:11:39
date last changed
2017-08-06 03:33:16
@article{344243c6-7f09-4638-aa90-13260340e66b,
  abstract     = {The translocation t(8;16) (p11;p13) was found as the sole deviation from the normal karyotype in three patients with acute monocytic leukaemia. The bone marrow morphology was strikingly similar in the two cases where smears were available for re-evaluation: the leukaemic cells showed signs of differentiation, and active erythrophagocytosis was a particularly conspicuous feature. We suggest that t(8;16) (p11;p13) represents a new consistent abnormality in acute monocytic leukaemia, specifically associated with the differentiated subtype (M5b) and with pronounced phagocytic activity by the leukaemic monocytes.},
  author       = {Heim, Sverre and Avanzi, Gian-Carlo and Billström, Rolf and Kristoffersson, Ulf and Mandahl, Nils and Békássy, Albert and Garwicz, Stanislaw and Wiebe, Thomas and Pegoraro, Loigi and Falda, Michele and Resegotti, Luigi and Mitelman, Felix},
  issn         = {0007-1048},
  language     = {eng},
  number       = {3},
  pages        = {323--326},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {British Journal of Haematology},
  title        = {A new specific chromosomal rearrangement, t(8;16) (p11;p13), in acute monocytic leukaemia},
  url          = {http://dx.doi.org/10.1111/j.1365-2141.1987.00323.x},
  volume       = {66},
  year         = {1987},
}