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Control of traumatic liver hemorrhage in the cirrhotic rat by intraportal infusion of norepinephrine

Vagianos, Constantin; Steen, Stig LU ; Zoucas, Evita; Asakawa, H; Jeppsson, Bengt LU and Bengmark, Stig LU (1987) In Research in Experimental Medicine 187(5). p.339-346
Abstract
The effect of intraportal infusion of norepinephrine (NE) on primary hemostasis in the cirrhotic rat was investigated at standardized liver trauma. Cirrhosis was induced by simultaneous administration of increasing amounts of carbontetrachloride (CCl4) and phenobarbitone. Infusion of norepinephrine took place after cannulation of the gastroduodenal vein. Intraportal infusion of NE resulted in a significant increase in arterial blood pressure and portal pressure in all animals. No difference was observed between cirrhotic and control rats. Cirrhotic animals bled longer and more profusely as compared with the controls. Infusion of NE resulted in significant decrease in bleeding time and blood loss. NE did not affect hematocrit, hemoglobin,... (More)
The effect of intraportal infusion of norepinephrine (NE) on primary hemostasis in the cirrhotic rat was investigated at standardized liver trauma. Cirrhosis was induced by simultaneous administration of increasing amounts of carbontetrachloride (CCl4) and phenobarbitone. Infusion of norepinephrine took place after cannulation of the gastroduodenal vein. Intraportal infusion of NE resulted in a significant increase in arterial blood pressure and portal pressure in all animals. No difference was observed between cirrhotic and control rats. Cirrhotic animals bled longer and more profusely as compared with the controls. Infusion of NE resulted in significant decrease in bleeding time and blood loss. NE did not affect hematocrit, hemoglobin, platelet, or white cell count. Platelet aggregation was not influenced by the compound. In conclusion, intraportal infusion of NE proved effective in decreasing hemorrhage at liver trauma in cirrhotic rats. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cirrhosis, Liver trauma, Hemorrhage, Norepinephrine
in
Research in Experimental Medicine
volume
187
issue
5
pages
339 - 346
publisher
Springer
external identifiers
  • pmid:3432739
  • scopus:0023484629
ISSN
0300-9130
DOI
10.1007/BF01855659
language
English
LU publication?
yes
id
d848bbf1-8f4b-4300-9b6b-19e50321e460 (old id 1103999)
date added to LUP
2008-08-08 17:30:22
date last changed
2017-01-01 04:28:57
@article{d848bbf1-8f4b-4300-9b6b-19e50321e460,
  abstract     = {The effect of intraportal infusion of norepinephrine (NE) on primary hemostasis in the cirrhotic rat was investigated at standardized liver trauma. Cirrhosis was induced by simultaneous administration of increasing amounts of carbontetrachloride (CCl4) and phenobarbitone. Infusion of norepinephrine took place after cannulation of the gastroduodenal vein. Intraportal infusion of NE resulted in a significant increase in arterial blood pressure and portal pressure in all animals. No difference was observed between cirrhotic and control rats. Cirrhotic animals bled longer and more profusely as compared with the controls. Infusion of NE resulted in significant decrease in bleeding time and blood loss. NE did not affect hematocrit, hemoglobin, platelet, or white cell count. Platelet aggregation was not influenced by the compound. In conclusion, intraportal infusion of NE proved effective in decreasing hemorrhage at liver trauma in cirrhotic rats.},
  author       = {Vagianos, Constantin and Steen, Stig and Zoucas, Evita and Asakawa, H and Jeppsson, Bengt and Bengmark, Stig},
  issn         = {0300-9130},
  keyword      = {Cirrhosis,Liver trauma,Hemorrhage,Norepinephrine},
  language     = {eng},
  number       = {5},
  pages        = {339--346},
  publisher    = {Springer},
  series       = {Research in Experimental Medicine},
  title        = {Control of traumatic liver hemorrhage in the cirrhotic rat by intraportal infusion of norepinephrine},
  url          = {http://dx.doi.org/10.1007/BF01855659},
  volume       = {187},
  year         = {1987},
}