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Contractility of human leg lymphatics during exercise before and after indomethacin

Sjöberg, Trygve LU ; Norgren, Lars LU and Steen, Stig LU (1989) In Lymphology 22(4). p.186-193
Abstract
Subcutaneous lymphatics in the lower leg were catheterized in the retrograde direction in 6 healthy male subjects. The catheter was connected to a pressure transducer, and pressure was measured during three stages of exercise including standing, tip-toeing, and running in place. Before the third stage, indomethacin (50mg) was given i.v. Rhythmic pressure waves were registered in each subject. During the second stage, when the subjects were "warmed up," the frequency (min-1) was 2.4 +/- 0.5 (mean +/- SEM). The corresponding values during tip-toeing and running were 5.8 +/- 0.7 (p less than 0.05) and 5.4 +/- 0.5 (p less than 0.05), respectively. The amplitudes (mean values between 3.2-4.7mmHg while standing) were not consistently altered... (More)
Subcutaneous lymphatics in the lower leg were catheterized in the retrograde direction in 6 healthy male subjects. The catheter was connected to a pressure transducer, and pressure was measured during three stages of exercise including standing, tip-toeing, and running in place. Before the third stage, indomethacin (50mg) was given i.v. Rhythmic pressure waves were registered in each subject. During the second stage, when the subjects were "warmed up," the frequency (min-1) was 2.4 +/- 0.5 (mean +/- SEM). The corresponding values during tip-toeing and running were 5.8 +/- 0.7 (p less than 0.05) and 5.4 +/- 0.5 (p less than 0.05), respectively. The amplitudes (mean values between 3.2-4.7mmHg while standing) were not consistently altered during tip-toeing or running in any of the three stages. During standing there was a negative correlation between frequency and amplitude. No such correlation was found during tip-toeing or running, or after injection of indomethacin. Indomethacin did not significantly alter any of the measured parameters, but in two subjects the frequencies and amplitudes were decreased (about 50%) during standing, tip-toeing, and running. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Lymphology
volume
22
issue
4
pages
186 - 193
publisher
International Society of Lymphology
external identifiers
  • pmid:2632994
  • scopus:0024834414
ISSN
0024-7766
language
English
LU publication?
yes
id
93c21afb-6b02-4c40-879c-c2b82bdbb9ce (old id 1104836)
date added to LUP
2008-08-06 15:56:27
date last changed
2017-01-01 07:17:23
@article{93c21afb-6b02-4c40-879c-c2b82bdbb9ce,
  abstract     = {Subcutaneous lymphatics in the lower leg were catheterized in the retrograde direction in 6 healthy male subjects. The catheter was connected to a pressure transducer, and pressure was measured during three stages of exercise including standing, tip-toeing, and running in place. Before the third stage, indomethacin (50mg) was given i.v. Rhythmic pressure waves were registered in each subject. During the second stage, when the subjects were "warmed up," the frequency (min-1) was 2.4 +/- 0.5 (mean +/- SEM). The corresponding values during tip-toeing and running were 5.8 +/- 0.7 (p less than 0.05) and 5.4 +/- 0.5 (p less than 0.05), respectively. The amplitudes (mean values between 3.2-4.7mmHg while standing) were not consistently altered during tip-toeing or running in any of the three stages. During standing there was a negative correlation between frequency and amplitude. No such correlation was found during tip-toeing or running, or after injection of indomethacin. Indomethacin did not significantly alter any of the measured parameters, but in two subjects the frequencies and amplitudes were decreased (about 50%) during standing, tip-toeing, and running.},
  author       = {Sjöberg, Trygve and Norgren, Lars and Steen, Stig},
  issn         = {0024-7766},
  language     = {eng},
  number       = {4},
  pages        = {186--193},
  publisher    = {International Society of Lymphology},
  series       = {Lymphology},
  title        = {Contractility of human leg lymphatics during exercise before and after indomethacin},
  volume       = {22},
  year         = {1989},
}