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Direct evidence of active sympathetic vasodilatation in the skin of the human foot

Lundberg, Johan LU ; Norgren, Lars LU ; Ribbe, Else LU ; Rosén, Ingmar LU ; Steen, Stig LU ; Thörne, Johan LU and Wallin, B Gunnar (1989) In Journal of Physiology 417. p.437-446
Abstract
1. During operative aorto-femoral vascular reconstructions on sixteen patients, the sympathetic chain was stimulated electrically between the L2 and L4 ganglia while blood flow was monitored by laser doppler flowmeters from the skin on the sole of the foot and the ankle and by an electromagnetic flowmeter from the deep femoral artery. Epidural anaesthesia to at least the T6 level was used which excluded reflex effects. 2. Stimulation (10 Hz) at 1-12 mA current strengths for 30 s evoked both reductions and increases of blood flow in glabrous and hairy skin. Initial short-lasting flow increases (durations 9-19 s) followed by sustained decreases were common: sometimes there were sustained flow increases at low and decreases at high current... (More)
1. During operative aorto-femoral vascular reconstructions on sixteen patients, the sympathetic chain was stimulated electrically between the L2 and L4 ganglia while blood flow was monitored by laser doppler flowmeters from the skin on the sole of the foot and the ankle and by an electromagnetic flowmeter from the deep femoral artery. Epidural anaesthesia to at least the T6 level was used which excluded reflex effects. 2. Stimulation (10 Hz) at 1-12 mA current strengths for 30 s evoked both reductions and increases of blood flow in glabrous and hairy skin. Initial short-lasting flow increases (durations 9-19 s) followed by sustained decreases were common: sometimes there were sustained flow increases at low and decreases at high current strengths. 3. In the deep femoral artery (supplying predominantly muscle) only flow reductions were evoked. 4. The results provide evidence for sympathetically mediated vasodilatation in the skin of the human foot whereas leg muscles may be supplied by vasoconstrictor nerves only. (Less)
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author
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Contribution to journal
publication status
published
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in
Journal of Physiology
volume
417
pages
437 - 446
publisher
The Physiological Society
external identifiers
  • pmid:2621604
  • scopus:0024445467
ISSN
1469-7793
language
English
LU publication?
yes
id
ef9b7825-20f4-4263-8531-d09f409236a4 (old id 1104845)
alternative location
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1189276&blobtype=pdf
http://jp.physoc.org/cgi/reprint/417/1/437
date added to LUP
2008-08-06 16:06:09
date last changed
2017-08-06 04:39:30
@article{ef9b7825-20f4-4263-8531-d09f409236a4,
  abstract     = {1. During operative aorto-femoral vascular reconstructions on sixteen patients, the sympathetic chain was stimulated electrically between the L2 and L4 ganglia while blood flow was monitored by laser doppler flowmeters from the skin on the sole of the foot and the ankle and by an electromagnetic flowmeter from the deep femoral artery. Epidural anaesthesia to at least the T6 level was used which excluded reflex effects. 2. Stimulation (10 Hz) at 1-12 mA current strengths for 30 s evoked both reductions and increases of blood flow in glabrous and hairy skin. Initial short-lasting flow increases (durations 9-19 s) followed by sustained decreases were common: sometimes there were sustained flow increases at low and decreases at high current strengths. 3. In the deep femoral artery (supplying predominantly muscle) only flow reductions were evoked. 4. The results provide evidence for sympathetically mediated vasodilatation in the skin of the human foot whereas leg muscles may be supplied by vasoconstrictor nerves only.},
  author       = {Lundberg, Johan and Norgren, Lars and Ribbe, Else and Rosén, Ingmar and Steen, Stig and Thörne, Johan and Wallin, B Gunnar},
  issn         = {1469-7793},
  language     = {eng},
  pages        = {437--446},
  publisher    = {The Physiological Society},
  series       = {Journal of Physiology},
  title        = {Direct evidence of active sympathetic vasodilatation in the skin of the human foot},
  volume       = {417},
  year         = {1989},
}