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Endothelin is a potent constrictor of human intracranial arteries and veins

Hardebo, Jan Erik LU ; Kåhrström, J; Owman, Christer LU and Salford, Leif LU (1989) In Blood Vessels 26(5). p.249-253
Abstract
Endothelin, a peptide produced in endothelial cells, was found to be a potent constrictor of human pial arteries through a direct, slow action on the smooth muscle cell, with a pD2 value of 8.54. It was less potent as a constrictor in pial veins (pD2 7.80) and in branches of the middle meningeal artery and superficial temporal artery (pD2 7.61 and 7.77). The major component of the contractile response in the arteries comprises an effect on potential-operated calcium channels, as evidenced by tests with nimodipine. Endothelin may regulate intracranial vessels tonically during physiological as well as pathophysiological conditions.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood Vessels
volume
26
issue
5
pages
249 - 253
publisher
Karger
external identifiers
  • pmid:2561394
ISSN
0303-6847
language
English
LU publication?
yes
id
26946464-667c-49e5-ab01-5c9a620d718c (old id 1104931)
date added to LUP
2008-08-07 09:06:37
date last changed
2016-04-16 03:10:55
@article{26946464-667c-49e5-ab01-5c9a620d718c,
  abstract     = {Endothelin, a peptide produced in endothelial cells, was found to be a potent constrictor of human pial arteries through a direct, slow action on the smooth muscle cell, with a pD2 value of 8.54. It was less potent as a constrictor in pial veins (pD2 7.80) and in branches of the middle meningeal artery and superficial temporal artery (pD2 7.61 and 7.77). The major component of the contractile response in the arteries comprises an effect on potential-operated calcium channels, as evidenced by tests with nimodipine. Endothelin may regulate intracranial vessels tonically during physiological as well as pathophysiological conditions.},
  author       = {Hardebo, Jan Erik and Kåhrström, J and Owman, Christer and Salford, Leif},
  issn         = {0303-6847},
  language     = {eng},
  number       = {5},
  pages        = {249--253},
  publisher    = {Karger},
  series       = {Blood Vessels},
  title        = {Endothelin is a potent constrictor of human intracranial arteries and veins},
  volume       = {26},
  year         = {1989},
}