Endothelin is a potent constrictor of human intracranial arteries and veins
(1989) In Blood Vessels 26(5). p.249-253- Abstract
- Endothelin, a peptide produced in endothelial cells, was found to be a potent constrictor of human pial arteries through a direct, slow action on the smooth muscle cell, with a pD2 value of 8.54. It was less potent as a constrictor in pial veins (pD2 7.80) and in branches of the middle meningeal artery and superficial temporal artery (pD2 7.61 and 7.77). The major component of the contractile response in the arteries comprises an effect on potential-operated calcium channels, as evidenced by tests with nimodipine. Endothelin may regulate intracranial vessels tonically during physiological as well as pathophysiological conditions.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1104931
- author
- Hardebo, Jan Erik LU ; Kåhrström, J ; Owman, Christer LU and Salford, Leif LU
- organization
- publishing date
- 1989
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Blood Vessels
- volume
- 26
- issue
- 5
- pages
- 249 - 253
- publisher
- Karger
- external identifiers
-
- pmid:2561394
- scopus:0024955710
- ISSN
- 0303-6847
- language
- English
- LU publication?
- yes
- id
- 26946464-667c-49e5-ab01-5c9a620d718c (old id 1104931)
- date added to LUP
- 2016-04-01 15:38:37
- date last changed
- 2021-01-03 08:34:34
@article{26946464-667c-49e5-ab01-5c9a620d718c, abstract = {{Endothelin, a peptide produced in endothelial cells, was found to be a potent constrictor of human pial arteries through a direct, slow action on the smooth muscle cell, with a pD2 value of 8.54. It was less potent as a constrictor in pial veins (pD2 7.80) and in branches of the middle meningeal artery and superficial temporal artery (pD2 7.61 and 7.77). The major component of the contractile response in the arteries comprises an effect on potential-operated calcium channels, as evidenced by tests with nimodipine. Endothelin may regulate intracranial vessels tonically during physiological as well as pathophysiological conditions.}}, author = {{Hardebo, Jan Erik and Kåhrström, J and Owman, Christer and Salford, Leif}}, issn = {{0303-6847}}, language = {{eng}}, number = {{5}}, pages = {{249--253}}, publisher = {{Karger}}, series = {{Blood Vessels}}, title = {{Endothelin is a potent constrictor of human intracranial arteries and veins}}, volume = {{26}}, year = {{1989}}, }