Bone marrow karyotypes in 94 children with acute leukemia
Heim, Sverre LU ; Békássy, Albert LU ; Garwicz, Stanislaw LU ; Heldrup, Jesper LU ; Kristoffersson, Ulf LU ; Mandahl, Nils LU ; Wiebe, Thomas LU and Mitelman, Felix LU
(1990)
In European Journal of Haematology
44(4).
p.227-233
- Abstract
- During the last 10 years, we have cytogenetically analyzed at diagnosis bone marrow cells from a total of 94 children with acute leukemia. Of the 78 children with acute lymphatic leukemia (ALL), 53 (68%) had clonal acquired chromosome abnormalities; in the group with acute nonlymphatic leukemia (ANLL), the corresponding proportion was 13 out of 16 (81%). Among the cytogenetically abnormal ALL patients, the most numerous subset was the hyperdiploid cases with stemlines containing 51 or more chromosomes (26 of 53 abnormal cases; 49%). This is a clearly higher proportion than has been reported in large series from other centers. Deletions of 6q were present in 8 cases and rearrangements of 12p in 5. Of the 7 T-cell ALLs, 3 had translocations... (More)
- During the last 10 years, we have cytogenetically analyzed at diagnosis bone marrow cells from a total of 94 children with acute leukemia. Of the 78 children with acute lymphatic leukemia (ALL), 53 (68%) had clonal acquired chromosome abnormalities; in the group with acute nonlymphatic leukemia (ANLL), the corresponding proportion was 13 out of 16 (81%). Among the cytogenetically abnormal ALL patients, the most numerous subset was the hyperdiploid cases with stemlines containing 51 or more chromosomes (26 of 53 abnormal cases; 49%). This is a clearly higher proportion than has been reported in large series from other centers. Deletions of 6q were present in 8 cases and rearrangements of 12p in 5. Of the 7 T-cell ALLs, 3 had translocations of the distal part of 7q, i.e., of the region where the beta T-cell receptor is encoded. Only 2 of 26 (8%) patients with leukemic stemlines with more than 50 chromosomes have relapsed; the remainder are still in first remission (mean observation time 42 months). This may be contrasted with 6 of 25 (24%) relapses among the cytogenetically normal (observation time 41 months), and 8 of 27 (30%) relapses among ALL patients with aberrations but with less than 51 chromosomes (observation time 26 months). Our results support the conclusion that the finding of a markedly hyperdiploid leukemia karyotype is indicative of good prognosis in ALL. (Less)
Please use this url to cite or link to this publication:
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- author
- Heim, Sverre
LU
; Békássy, Albert
LU
; Garwicz, Stanislaw
LU
; Heldrup, Jesper
LU
; Kristoffersson, Ulf
LU
; Mandahl, Nils
LU
; Wiebe, Thomas
LU
and Mitelman, Felix
LU
- organization
- publishing date
- 1990
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Haematology
- volume
- 44
- issue
- 4
- pages
- 227 - 233
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:2344885
- scopus:0025314507
- ISSN
- 1600-0609
- language
- English
- LU publication?
- yes
- id
- 1ea643c6-0296-40cb-9f66-605923c96c1a (old id 1104962)
- date added to LUP
- 2016-04-01 11:42:28
- date last changed
- 2025-04-04 15:09:01
@article{1ea643c6-0296-40cb-9f66-605923c96c1a,
abstract = {{During the last 10 years, we have cytogenetically analyzed at diagnosis bone marrow cells from a total of 94 children with acute leukemia. Of the 78 children with acute lymphatic leukemia (ALL), 53 (68%) had clonal acquired chromosome abnormalities; in the group with acute nonlymphatic leukemia (ANLL), the corresponding proportion was 13 out of 16 (81%). Among the cytogenetically abnormal ALL patients, the most numerous subset was the hyperdiploid cases with stemlines containing 51 or more chromosomes (26 of 53 abnormal cases; 49%). This is a clearly higher proportion than has been reported in large series from other centers. Deletions of 6q were present in 8 cases and rearrangements of 12p in 5. Of the 7 T-cell ALLs, 3 had translocations of the distal part of 7q, i.e., of the region where the beta T-cell receptor is encoded. Only 2 of 26 (8%) patients with leukemic stemlines with more than 50 chromosomes have relapsed; the remainder are still in first remission (mean observation time 42 months). This may be contrasted with 6 of 25 (24%) relapses among the cytogenetically normal (observation time 41 months), and 8 of 27 (30%) relapses among ALL patients with aberrations but with less than 51 chromosomes (observation time 26 months). Our results support the conclusion that the finding of a markedly hyperdiploid leukemia karyotype is indicative of good prognosis in ALL.}},
author = {{Heim, Sverre and Békássy, Albert and Garwicz, Stanislaw and Heldrup, Jesper and Kristoffersson, Ulf and Mandahl, Nils and Wiebe, Thomas and Mitelman, Felix}},
issn = {{1600-0609}},
language = {{eng}},
number = {{4}},
pages = {{227--233}},
publisher = {{Wiley-Blackwell}},
series = {{European Journal of Haematology}},
title = {{Bone marrow karyotypes in 94 children with acute leukemia}},
volume = {{44}},
year = {{1990}},
}