Advanced

Metabolism and force in hypertrophic smooth muscle from rat urinary bladder

Arner, Anders LU ; Malmqvist, Ulf LU and Uvelius, Bengt LU (1990) In American Journal of Physiology 258(5 Pt 1). p.923-932
Abstract
Ten days of urinary outlet obstruction in the rat induced a threefold increase in bladder weight. Active force of control and hypertrophic bladder muscle strips was measured at varying PO2 levels after high-K+, carbachol, or electrical field stimulation. Highest force output was obtained with carbachol. Force per muscle area was lower in the hypertrophic muscles. The basal rates of oxygen consumption and lactate formation were similar in the two groups. The metabolic tension cost (ATP turnover/active force) was similar in the two groups for activation with high K+ and carbachol. In anoxia the active force decreased, but this was less pronounced in the hypertrophied muscle. Hypertrophied muscle could, in contrast to the controls, maintain a... (More)
Ten days of urinary outlet obstruction in the rat induced a threefold increase in bladder weight. Active force of control and hypertrophic bladder muscle strips was measured at varying PO2 levels after high-K+, carbachol, or electrical field stimulation. Highest force output was obtained with carbachol. Force per muscle area was lower in the hypertrophic muscles. The basal rates of oxygen consumption and lactate formation were similar in the two groups. The metabolic tension cost (ATP turnover/active force) was similar in the two groups for activation with high K+ and carbachol. In anoxia the active force decreased, but this was less pronounced in the hypertrophied muscle. Hypertrophied muscle could, in contrast to the controls, maintain a sustained K+ contracture in anoxia. Basal metabolic rates and tension cost were markedly reduced in anoxia for both groups. The lower force per area with unaltered tension cost, in hypertrophic muscles under all experimental conditions, may reflect unaltered intrinsic properties of the contractile system, although the amount of contractile material has decreased relative to cell volume. The increased resistance to anoxia may reflect a metabolic adaptation to impaired oxygen supply to the hypertrophied tissue. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Physiology
volume
258
issue
5 Pt 1
pages
923 - 932
publisher
American Pysiological Society
external identifiers
  • pmid:2333984
  • scopus:0025291550
ISSN
0002-9513
language
English
LU publication?
yes
id
226c9af8-68c8-4bf0-9cf9-5e71aa056766 (old id 1105465)
alternative location
http://ajpcell.physiology.org/cgi/reprint/258/5/C923
date added to LUP
2008-08-05 15:49:57
date last changed
2017-02-22 11:44:33
@article{226c9af8-68c8-4bf0-9cf9-5e71aa056766,
  abstract     = {Ten days of urinary outlet obstruction in the rat induced a threefold increase in bladder weight. Active force of control and hypertrophic bladder muscle strips was measured at varying PO2 levels after high-K+, carbachol, or electrical field stimulation. Highest force output was obtained with carbachol. Force per muscle area was lower in the hypertrophic muscles. The basal rates of oxygen consumption and lactate formation were similar in the two groups. The metabolic tension cost (ATP turnover/active force) was similar in the two groups for activation with high K+ and carbachol. In anoxia the active force decreased, but this was less pronounced in the hypertrophied muscle. Hypertrophied muscle could, in contrast to the controls, maintain a sustained K+ contracture in anoxia. Basal metabolic rates and tension cost were markedly reduced in anoxia for both groups. The lower force per area with unaltered tension cost, in hypertrophic muscles under all experimental conditions, may reflect unaltered intrinsic properties of the contractile system, although the amount of contractile material has decreased relative to cell volume. The increased resistance to anoxia may reflect a metabolic adaptation to impaired oxygen supply to the hypertrophied tissue.},
  author       = {Arner, Anders and Malmqvist, Ulf and Uvelius, Bengt},
  issn         = {0002-9513},
  language     = {eng},
  number       = {5 Pt 1},
  pages        = {923--932},
  publisher    = {American Pysiological Society},
  series       = {American Journal of Physiology},
  title        = {Metabolism and force in hypertrophic smooth muscle from rat urinary bladder},
  volume       = {258},
  year         = {1990},
}