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Cytogenetic findings in 33 osteosarcomas

Mertens, F LU ; Mandahl, N LU ; Orndal, C ; Baldetorp, B LU ; Bauer, H C ; Rydholm, A LU ; Wiebe, T LU ; Willén, H ; Åkerman, Måns LU and Heim, S LU (1993) In International Journal of Cancer 55(1). p.44-50
Abstract

Thirty-three osteosarcomas (OS) were analyzed cytogenetically. Clonal chromosome changes were detected in 17 cases. Six tumors had chromosome numbers in the diploid range, 6 in the triploid range, 1 in the tetraploid range and 1 in the pentaploid range, while 3 tumors had multiple clones with different ploidy levels. Including the present 17 tumors, a total of 27 OS with clonal aberrations have been reported. The recognizable structural rearrangements in these 27 tumors clustered to chromosome arms 1p, 1q, 3p, 3q, 7q, 11p, 17p and 22q. Chromosome bands 1q11, 1q21, 1q42 and 7q11 were the most frequently rearranged, and the most common numerical rearrangements were -3, -10, -13 and -15. Supernumerary ring chromosomes, in 2 tumors as the... (More)

Thirty-three osteosarcomas (OS) were analyzed cytogenetically. Clonal chromosome changes were detected in 17 cases. Six tumors had chromosome numbers in the diploid range, 6 in the triploid range, 1 in the tetraploid range and 1 in the pentaploid range, while 3 tumors had multiple clones with different ploidy levels. Including the present 17 tumors, a total of 27 OS with clonal aberrations have been reported. The recognizable structural rearrangements in these 27 tumors clustered to chromosome arms 1p, 1q, 3p, 3q, 7q, 11p, 17p and 22q. Chromosome bands 1q11, 1q21, 1q42 and 7q11 were the most frequently rearranged, and the most common numerical rearrangements were -3, -10, -13 and -15. Supernumerary ring chromosomes, in 2 tumors as the sole change, were found in all 3 parosteal OS, which is in agreement with the findings in 1 previously reported parosteal OS. The association between ring formation and parosteal morphology represents the first cytogenetic-morphologic entity among OS.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescent, Adult, Aged, Aged, 80 and over, Bone Neoplasms, Child, Child, Preschool, Chromosome Aberrations, DNA, Neoplasm, Female, Flow Cytometry, Humans, Karyotyping, Male, Middle Aged, Osteosarcoma, Ploidies, Ring Chromosomes, Journal Article, Research Support, Non-U.S. Gov't
in
International Journal of Cancer
volume
55
issue
1
pages
7 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:8344751
  • scopus:0027219679
  • pmid:8344751
ISSN
0020-7136
DOI
10.1002/ijc.2910550109
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Orthopaedics (Lund) (013028000), Oncology, MV (013035000), Division of Clinical Genetics (013022003), Pathology, (Lund) (013030000), Department of Clinical Sciences, Lund (013230000)
id
4454ab89-6e8d-474b-b2c8-53957b59c224 (old id 1107024)
date added to LUP
2016-04-01 11:40:09
date last changed
2021-01-03 03:00:53
@article{4454ab89-6e8d-474b-b2c8-53957b59c224,
  abstract     = {{<p>Thirty-three osteosarcomas (OS) were analyzed cytogenetically. Clonal chromosome changes were detected in 17 cases. Six tumors had chromosome numbers in the diploid range, 6 in the triploid range, 1 in the tetraploid range and 1 in the pentaploid range, while 3 tumors had multiple clones with different ploidy levels. Including the present 17 tumors, a total of 27 OS with clonal aberrations have been reported. The recognizable structural rearrangements in these 27 tumors clustered to chromosome arms 1p, 1q, 3p, 3q, 7q, 11p, 17p and 22q. Chromosome bands 1q11, 1q21, 1q42 and 7q11 were the most frequently rearranged, and the most common numerical rearrangements were -3, -10, -13 and -15. Supernumerary ring chromosomes, in 2 tumors as the sole change, were found in all 3 parosteal OS, which is in agreement with the findings in 1 previously reported parosteal OS. The association between ring formation and parosteal morphology represents the first cytogenetic-morphologic entity among OS.</p>}},
  author       = {{Mertens, F and Mandahl, N and Orndal, C and Baldetorp, B and Bauer, H C and Rydholm, A and Wiebe, T and Willén, H and Åkerman, Måns and Heim, S}},
  issn         = {{0020-7136}},
  keywords     = {{Adolescent; Adult; Aged; Aged, 80 and over; Bone Neoplasms; Child; Child, Preschool; Chromosome Aberrations; DNA, Neoplasm; Female; Flow Cytometry; Humans; Karyotyping; Male; Middle Aged; Osteosarcoma; Ploidies; Ring Chromosomes; Journal Article; Research Support, Non-U.S. Gov't}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{1}},
  pages        = {{44--50}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Cytogenetic findings in 33 osteosarcomas}},
  url          = {{http://dx.doi.org/10.1002/ijc.2910550109}},
  doi          = {{10.1002/ijc.2910550109}},
  volume       = {{55}},
  year         = {{1993}},
}