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Serum osteocalcin and fracture susceptibility in elderly women

Åkesson, Kristina LU ; Ljunghall, Sverker; Gärdsell, Per; Sernbo, Ingemar LU and Obrant, Karl LU (1993) In Calcified Tissue International 53(2). p.86-90
Abstract
The purpose of this investigation was to evaluate the bone turnover by using bone metabolic markers in relation to previous fracture history and independent of bone mass. Patients and controls were recruited from a population-based study of 193 women, all living in the same city and aged 60, 70, and 80 years. The bone mineral content (BMC) was measured bilaterally in the distal forearm by single-photon absorptiometry (SPA). At the same time, serum samples were obtained for biochemical analysis. Of the 193 women, we identified 26 with at least one major fracture during the past few years. Each of these 26 women with a certified recent previous fracture was individually matched with a woman from the same study group of equal BMC and age but... (More)
The purpose of this investigation was to evaluate the bone turnover by using bone metabolic markers in relation to previous fracture history and independent of bone mass. Patients and controls were recruited from a population-based study of 193 women, all living in the same city and aged 60, 70, and 80 years. The bone mineral content (BMC) was measured bilaterally in the distal forearm by single-photon absorptiometry (SPA). At the same time, serum samples were obtained for biochemical analysis. Of the 193 women, we identified 26 with at least one major fracture during the past few years. Each of these 26 women with a certified recent previous fracture was individually matched with a woman from the same study group of equal BMC and age but without a fracture history. In the two groups, the serum samples were analyzed for osteocalcin, C-terminal procollagen peptide (P1CP), alkaline phosphatase, bone-specific alkaline phosphatase, calcium, phosphate, and albumin. The serum concentration of osteocalcin was 20% lower in the women with a previous fracture than in the controls (P = 0.03). The other markers of bone formation gave similar values in the two groups. There was a significant correlation between the osteocalcin and P1CP concentrations (P = 0.001). Our findings indicate that the susceptibility to fractures independent of factors such as age and BMC may be related to a decreased bone turnover. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Calcified Tissue International
volume
53
issue
2
pages
86 - 90
publisher
Springer
external identifiers
  • pmid:8402327
  • scopus:0027209559
ISSN
1432-0827
DOI
10.1007/BF01321884
language
English
LU publication?
yes
id
d3a9fc2e-6772-44c0-b474-3630c5feae37 (old id 1107268)
date added to LUP
2008-07-30 14:42:03
date last changed
2017-01-01 07:23:32
@article{d3a9fc2e-6772-44c0-b474-3630c5feae37,
  abstract     = {The purpose of this investigation was to evaluate the bone turnover by using bone metabolic markers in relation to previous fracture history and independent of bone mass. Patients and controls were recruited from a population-based study of 193 women, all living in the same city and aged 60, 70, and 80 years. The bone mineral content (BMC) was measured bilaterally in the distal forearm by single-photon absorptiometry (SPA). At the same time, serum samples were obtained for biochemical analysis. Of the 193 women, we identified 26 with at least one major fracture during the past few years. Each of these 26 women with a certified recent previous fracture was individually matched with a woman from the same study group of equal BMC and age but without a fracture history. In the two groups, the serum samples were analyzed for osteocalcin, C-terminal procollagen peptide (P1CP), alkaline phosphatase, bone-specific alkaline phosphatase, calcium, phosphate, and albumin. The serum concentration of osteocalcin was 20% lower in the women with a previous fracture than in the controls (P = 0.03). The other markers of bone formation gave similar values in the two groups. There was a significant correlation between the osteocalcin and P1CP concentrations (P = 0.001). Our findings indicate that the susceptibility to fractures independent of factors such as age and BMC may be related to a decreased bone turnover.},
  author       = {Åkesson, Kristina and Ljunghall, Sverker and Gärdsell, Per and Sernbo, Ingemar and Obrant, Karl},
  issn         = {1432-0827},
  language     = {eng},
  number       = {2},
  pages        = {86--90},
  publisher    = {Springer},
  series       = {Calcified Tissue International},
  title        = {Serum osteocalcin and fracture susceptibility in elderly women},
  url          = {http://dx.doi.org/10.1007/BF01321884},
  volume       = {53},
  year         = {1993},
}