Localization of hormone-sensitive lipase to rat Sertoli cells and its expression in developing and degenerating testes
(1994) In FEBS Letters 355(2). p.125-130- Abstract
- Using in situ hybridization, hormone-sensitive lipase was found to be expressed in a stage-dependent manner in Sertoli cells of rat testis. No expression was found in Leydig cells but expression in spermatids could not be excluded. These results suggest a role for hormone-sensitive lipase in the metabolism of lipid droplets in Sertoli cells, in contrast to its previously proposed function in steroid biosynthesis. The expression of testicular hormone-sensitive lipase mRNA and protein, both larger in size compared to other tissues, coincided with the onset of spermatogenesis and was dependent on scrotal localization of the testis, suggesting a temperature-dependent, pretranslational regulation of expression.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1107741
- author
- Stenson, Lena LU ; Hoffmann, Anna Maria ; Mulder, Hindrik LU ; Sundler, Frank LU ; Holm, Cecilia LU ; Bergh, Anders and Fredrikson, Gudrun
- organization
- publishing date
- 1994
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Hormone sensitive lipase, Cholesterol ester hydrolase, Testis, Sertoli cell, In situ hybridization
- in
- FEBS Letters
- volume
- 355
- issue
- 2
- pages
- 125 - 130
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:7982484
- scopus:0028073597
- ISSN
- 1873-3468
- DOI
- 10.1016/0014-5793(94)01185-0
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Molecular Endocrinology (013212018), Neuroendocrine Cell Biology (013212008), Molecular Metabolism (013212001), Insulin Signal Transduction (013212014)
- id
- 68cf939c-dfa8-473a-b921-b8d9cd082102 (old id 1107741)
- date added to LUP
- 2016-04-01 15:24:40
- date last changed
- 2021-01-03 03:32:20
@article{68cf939c-dfa8-473a-b921-b8d9cd082102, abstract = {{Using in situ hybridization, hormone-sensitive lipase was found to be expressed in a stage-dependent manner in Sertoli cells of rat testis. No expression was found in Leydig cells but expression in spermatids could not be excluded. These results suggest a role for hormone-sensitive lipase in the metabolism of lipid droplets in Sertoli cells, in contrast to its previously proposed function in steroid biosynthesis. The expression of testicular hormone-sensitive lipase mRNA and protein, both larger in size compared to other tissues, coincided with the onset of spermatogenesis and was dependent on scrotal localization of the testis, suggesting a temperature-dependent, pretranslational regulation of expression.}}, author = {{Stenson, Lena and Hoffmann, Anna Maria and Mulder, Hindrik and Sundler, Frank and Holm, Cecilia and Bergh, Anders and Fredrikson, Gudrun}}, issn = {{1873-3468}}, keywords = {{Hormone sensitive lipase; Cholesterol ester hydrolase; Testis; Sertoli cell; In situ hybridization}}, language = {{eng}}, number = {{2}}, pages = {{125--130}}, publisher = {{Wiley-Blackwell}}, series = {{FEBS Letters}}, title = {{Localization of hormone-sensitive lipase to rat Sertoli cells and its expression in developing and degenerating testes}}, url = {{http://dx.doi.org/10.1016/0014-5793(94)01185-0}}, doi = {{10.1016/0014-5793(94)01185-0}}, volume = {{355}}, year = {{1994}}, }