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Prognostic value of Ki-67 expression in 182 soft tissue sarcomas. Proliferation--a marker of metastasis?

Choong, P F; Åkerman, Måns LU ; Willen, H; Andersson, C; Gustafson, P; Baldetorp, Bo LU ; Fernö, Mårten LU ; Alvegård, Thor LU and Rydholm, Anders LU (1994) In Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS) 102(12). p.915-924
Abstract
Soft tissue sarcomas (STS) are characterized by deregulated proliferation. Ki-67 is a cell cycle antigen which may be elevated in proliferative states. We analysed Ki-67 expression in fixed and embedded tissues from STS in order to examine associations between proliferation, primary tumour characteristics, and metastasis. One hundred and eighty-two adult patients with trunk wall or extremity STS were treated at our institution between 1980 and 1992 (35 developed local recurrence and 56 developed metastases). Median follow-up time for survivors was 6 years (1-13). We used a semiquantitative score to the assess percentage of Ki-67-positive cells: < or = 10% (n = 86), > 10-25% (n = 57), > 25-50% (n = 30), > 50-75% (n = 7), >... (More)
Soft tissue sarcomas (STS) are characterized by deregulated proliferation. Ki-67 is a cell cycle antigen which may be elevated in proliferative states. We analysed Ki-67 expression in fixed and embedded tissues from STS in order to examine associations between proliferation, primary tumour characteristics, and metastasis. One hundred and eighty-two adult patients with trunk wall or extremity STS were treated at our institution between 1980 and 1992 (35 developed local recurrence and 56 developed metastases). Median follow-up time for survivors was 6 years (1-13). We used a semiquantitative score to the assess percentage of Ki-67-positive cells: < or = 10% (n = 86), > 10-25% (n = 57), > 25-50% (n = 30), > 50-75% (n = 7), > 75-100% (n = 2). Increasing Ki-67 expression correlated positively with tumour size, malignancy grade, necrosis, vascular invasion, S-phase fraction, and metastasis. A Ki-67 index Ki-D < or = 10% (n = 86) and > 10% (n = 96) defined two groups who had 84% and 56% 3-year metastasis-free survival (p = 0.0001), respectively. Tumours with Ki-D > 10 were typically large, high grade, necrotic, DNA aneuploid, and had intravascular invasion and a higher S-phase fraction. Ki-67 expression may be helpful in predicting survival of patients with soft tissue sarcomas. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)
volume
102
issue
12
pages
915 - 924
publisher
John Wiley & Sons
external identifiers
  • pmid:7888160
  • scopus:0028631784
ISSN
1600-0463
language
English
LU publication?
yes
id
d9efd9e9-bfbd-4382-9355-ac6092b47115 (old id 1107784)
date added to LUP
2008-07-22 15:21:26
date last changed
2017-11-19 03:36:11
@article{d9efd9e9-bfbd-4382-9355-ac6092b47115,
  abstract     = {Soft tissue sarcomas (STS) are characterized by deregulated proliferation. Ki-67 is a cell cycle antigen which may be elevated in proliferative states. We analysed Ki-67 expression in fixed and embedded tissues from STS in order to examine associations between proliferation, primary tumour characteristics, and metastasis. One hundred and eighty-two adult patients with trunk wall or extremity STS were treated at our institution between 1980 and 1992 (35 developed local recurrence and 56 developed metastases). Median follow-up time for survivors was 6 years (1-13). We used a semiquantitative score to the assess percentage of Ki-67-positive cells: &lt; or = 10% (n = 86), &gt; 10-25% (n = 57), &gt; 25-50% (n = 30), &gt; 50-75% (n = 7), &gt; 75-100% (n = 2). Increasing Ki-67 expression correlated positively with tumour size, malignancy grade, necrosis, vascular invasion, S-phase fraction, and metastasis. A Ki-67 index Ki-D &lt; or = 10% (n = 86) and &gt; 10% (n = 96) defined two groups who had 84% and 56% 3-year metastasis-free survival (p = 0.0001), respectively. Tumours with Ki-D &gt; 10 were typically large, high grade, necrotic, DNA aneuploid, and had intravascular invasion and a higher S-phase fraction. Ki-67 expression may be helpful in predicting survival of patients with soft tissue sarcomas.},
  author       = {Choong, P F and Åkerman, Måns and Willen, H and Andersson, C and Gustafson, P and Baldetorp, Bo and Fernö, Mårten and Alvegård, Thor and Rydholm, Anders},
  issn         = {1600-0463},
  language     = {eng},
  number       = {12},
  pages        = {915--924},
  publisher    = {John Wiley & Sons},
  series       = {Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)},
  title        = {Prognostic value of Ki-67 expression in 182 soft tissue sarcomas. Proliferation--a marker of metastasis?},
  volume       = {102},
  year         = {1994},
}