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The prognostic information of DNA ploidy and S-phase fraction may vary with histologic grade in endometrial carcinoma

Gudmundsson, Thorkell E; Högberg, Thomas LU ; Alm, Per LU ; Anderson, Harald; Baldetorp, Bo LU ; Fernö, Mårten LU ; Langström, Eva and Killander, Dick LU (1995) In Acta Oncologica 34(6). p.803-812
Abstract
DNA ploidy and S-phase fraction (SPF) were determined by flow cytometry on paraffin-embedded tumor material from 243 patients treated during 1980-1985. Patients with well differentiated and moderately differentiated tumors without solid areas (n = 351) formed a low-risk group (corrected 5-year survival 90%). Twenty-four patients, dead of disease within 5 years, were compared with 52 survivors. The estimated death risk was higher for those with SPF > or = 8.0% compared with those with SPF < 8.0% (odds ratio = 18.2; p < 0.001). SPF was the only independent prognostic factor in a multivariate analysis also including age, clinical stage and grade of differentiation. Patients with moderately differentiated tumors with solid areas or... (More)
DNA ploidy and S-phase fraction (SPF) were determined by flow cytometry on paraffin-embedded tumor material from 243 patients treated during 1980-1985. Patients with well differentiated and moderately differentiated tumors without solid areas (n = 351) formed a low-risk group (corrected 5-year survival 90%). Twenty-four patients, dead of disease within 5 years, were compared with 52 survivors. The estimated death risk was higher for those with SPF > or = 8.0% compared with those with SPF < 8.0% (odds ratio = 18.2; p < 0.001). SPF was the only independent prognostic factor in a multivariate analysis also including age, clinical stage and grade of differentiation. Patients with moderately differentiated tumors with solid areas or poorly differentiated tumors (n = 208) were regarded as a high-risk group. There was a difference in survival according to ploidy; the corrected 5-year survival was 75% for 106 patients with diploid tumors compared with 44% for those with non-diploid tumors (p < 0.0001). In a multivariate analysis DNA ploidy, age and clinical stage were independent prognostic factors, whereas SPF was no longer significant. Thus, DNA ploidy and SPF have different prognostic values depending on histological grade of endometrial carcinoma. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
34
issue
6
pages
803 - 812
publisher
Taylor & Francis
external identifiers
  • pmid:7576749
  • scopus:0028798954
ISSN
1651-226X
DOI
10.3109/02841869509127190
language
English
LU publication?
yes
id
942a6fce-8387-431e-ab44-abc91baa6f2b (old id 1108887)
date added to LUP
2008-07-25 08:42:55
date last changed
2017-01-01 06:57:33
@article{942a6fce-8387-431e-ab44-abc91baa6f2b,
  abstract     = {DNA ploidy and S-phase fraction (SPF) were determined by flow cytometry on paraffin-embedded tumor material from 243 patients treated during 1980-1985. Patients with well differentiated and moderately differentiated tumors without solid areas (n = 351) formed a low-risk group (corrected 5-year survival 90%). Twenty-four patients, dead of disease within 5 years, were compared with 52 survivors. The estimated death risk was higher for those with SPF &gt; or = 8.0% compared with those with SPF &lt; 8.0% (odds ratio = 18.2; p &lt; 0.001). SPF was the only independent prognostic factor in a multivariate analysis also including age, clinical stage and grade of differentiation. Patients with moderately differentiated tumors with solid areas or poorly differentiated tumors (n = 208) were regarded as a high-risk group. There was a difference in survival according to ploidy; the corrected 5-year survival was 75% for 106 patients with diploid tumors compared with 44% for those with non-diploid tumors (p &lt; 0.0001). In a multivariate analysis DNA ploidy, age and clinical stage were independent prognostic factors, whereas SPF was no longer significant. Thus, DNA ploidy and SPF have different prognostic values depending on histological grade of endometrial carcinoma.},
  author       = {Gudmundsson, Thorkell E and Högberg, Thomas and Alm, Per and Anderson, Harald and Baldetorp, Bo and Fernö, Mårten and Langström, Eva and Killander, Dick},
  issn         = {1651-226X},
  language     = {eng},
  number       = {6},
  pages        = {803--812},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {The prognostic information of DNA ploidy and S-phase fraction may vary with histologic grade in endometrial carcinoma},
  url          = {http://dx.doi.org/10.3109/02841869509127190},
  volume       = {34},
  year         = {1995},
}