Serum osteocalcin increases during fracture healing in elderly women with hip fracture
(1995) In Bone 16(4). p.427-430- Abstract
- The purpose of this study was to define the bone metabolic properties during the postfracture period in elderly women with hip fracture. Osteocalcin (Oc), a marker of bone formation, was measured in 58 women with hip fracture (77 +/- 7 years) admitted to the hospital from their own homes. Serum samples were taken on average 5 h (range 1-21) from fracture and at follow-up, on average 4.6 months later. Comparison was made with 58 age-matched (79 +/- 5 years) women. Women with hip fracture had initially 30% lower Oc levels compared to the controls (p = 0.0001). The Oc level was independent of time elapsed from trauma, within 18 h, after which the level further decreased. At follow-up, Oc showed a 44% increase (p = 0.0001) and had reached the... (More)
- The purpose of this study was to define the bone metabolic properties during the postfracture period in elderly women with hip fracture. Osteocalcin (Oc), a marker of bone formation, was measured in 58 women with hip fracture (77 +/- 7 years) admitted to the hospital from their own homes. Serum samples were taken on average 5 h (range 1-21) from fracture and at follow-up, on average 4.6 months later. Comparison was made with 58 age-matched (79 +/- 5 years) women. Women with hip fracture had initially 30% lower Oc levels compared to the controls (p = 0.0001). The Oc level was independent of time elapsed from trauma, within 18 h, after which the level further decreased. At follow-up, Oc showed a 44% increase (p = 0.0001) and had reached the level of the controls, but not beyond it. A concomitant, but less marked increase was noted for alkaline phosphatase (ALP) (p = 0.0001). We conclude that although the bone formation, as assessed by Oc, is apparently lower in elderly women who sustain a hip fracture, the ability to induce a fracture response, with an increased bone turnover during fracture healing is intact. Subsequently, it is essential that a time perspective is applied, as the bone metabolic changes in patients having sustained a fracture are related to the time elapsed from fracture. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1109238
- author
- Åkesson, Kristina LU ; Vergnaud, P ; Delmas, P D and Obrant, Karl LU
- organization
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Bone
- volume
- 16
- issue
- 4
- pages
- 427 - 430
- publisher
- Elsevier
- external identifiers
-
- pmid:7605702
- scopus:0029149820
- ISSN
- 1873-2763
- DOI
- 10.1016/8756-3282(95)90187-6
- language
- English
- LU publication?
- yes
- id
- 77a4cfaf-3500-48e4-b2bf-76027a8c6c8c (old id 1109238)
- date added to LUP
- 2016-04-01 16:00:05
- date last changed
- 2024-01-10 23:41:30
@article{77a4cfaf-3500-48e4-b2bf-76027a8c6c8c,
abstract = {{The purpose of this study was to define the bone metabolic properties during the postfracture period in elderly women with hip fracture. Osteocalcin (Oc), a marker of bone formation, was measured in 58 women with hip fracture (77 +/- 7 years) admitted to the hospital from their own homes. Serum samples were taken on average 5 h (range 1-21) from fracture and at follow-up, on average 4.6 months later. Comparison was made with 58 age-matched (79 +/- 5 years) women. Women with hip fracture had initially 30% lower Oc levels compared to the controls (p = 0.0001). The Oc level was independent of time elapsed from trauma, within 18 h, after which the level further decreased. At follow-up, Oc showed a 44% increase (p = 0.0001) and had reached the level of the controls, but not beyond it. A concomitant, but less marked increase was noted for alkaline phosphatase (ALP) (p = 0.0001). We conclude that although the bone formation, as assessed by Oc, is apparently lower in elderly women who sustain a hip fracture, the ability to induce a fracture response, with an increased bone turnover during fracture healing is intact. Subsequently, it is essential that a time perspective is applied, as the bone metabolic changes in patients having sustained a fracture are related to the time elapsed from fracture.}},
author = {{Åkesson, Kristina and Vergnaud, P and Delmas, P D and Obrant, Karl}},
issn = {{1873-2763}},
language = {{eng}},
number = {{4}},
pages = {{427--430}},
publisher = {{Elsevier}},
series = {{Bone}},
title = {{Serum osteocalcin increases during fracture healing in elderly women with hip fracture}},
url = {{http://dx.doi.org/10.1016/8756-3282(95)90187-6}},
doi = {{10.1016/8756-3282(95)90187-6}},
volume = {{16}},
year = {{1995}},
}