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Serum osteocalcin increases during fracture healing in elderly women with hip fracture

Åkesson, Kristina LU ; Vergnaud, P; Delmas, P D and Obrant, Karl LU (1995) In Bone 16(4). p.427-430
Abstract
The purpose of this study was to define the bone metabolic properties during the postfracture period in elderly women with hip fracture. Osteocalcin (Oc), a marker of bone formation, was measured in 58 women with hip fracture (77 +/- 7 years) admitted to the hospital from their own homes. Serum samples were taken on average 5 h (range 1-21) from fracture and at follow-up, on average 4.6 months later. Comparison was made with 58 age-matched (79 +/- 5 years) women. Women with hip fracture had initially 30% lower Oc levels compared to the controls (p = 0.0001). The Oc level was independent of time elapsed from trauma, within 18 h, after which the level further decreased. At follow-up, Oc showed a 44% increase (p = 0.0001) and had reached the... (More)
The purpose of this study was to define the bone metabolic properties during the postfracture period in elderly women with hip fracture. Osteocalcin (Oc), a marker of bone formation, was measured in 58 women with hip fracture (77 +/- 7 years) admitted to the hospital from their own homes. Serum samples were taken on average 5 h (range 1-21) from fracture and at follow-up, on average 4.6 months later. Comparison was made with 58 age-matched (79 +/- 5 years) women. Women with hip fracture had initially 30% lower Oc levels compared to the controls (p = 0.0001). The Oc level was independent of time elapsed from trauma, within 18 h, after which the level further decreased. At follow-up, Oc showed a 44% increase (p = 0.0001) and had reached the level of the controls, but not beyond it. A concomitant, but less marked increase was noted for alkaline phosphatase (ALP) (p = 0.0001). We conclude that although the bone formation, as assessed by Oc, is apparently lower in elderly women who sustain a hip fracture, the ability to induce a fracture response, with an increased bone turnover during fracture healing is intact. Subsequently, it is essential that a time perspective is applied, as the bone metabolic changes in patients having sustained a fracture are related to the time elapsed from fracture. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Bone
volume
16
issue
4
pages
427 - 430
publisher
Elsevier
external identifiers
  • pmid:7605702
  • scopus:0029149820
ISSN
1873-2763
DOI
10.1016/8756-3282(95)90187-6
language
English
LU publication?
yes
id
77a4cfaf-3500-48e4-b2bf-76027a8c6c8c (old id 1109238)
date added to LUP
2008-07-25 16:15:00
date last changed
2017-01-01 06:52:57
@article{77a4cfaf-3500-48e4-b2bf-76027a8c6c8c,
  abstract     = {The purpose of this study was to define the bone metabolic properties during the postfracture period in elderly women with hip fracture. Osteocalcin (Oc), a marker of bone formation, was measured in 58 women with hip fracture (77 +/- 7 years) admitted to the hospital from their own homes. Serum samples were taken on average 5 h (range 1-21) from fracture and at follow-up, on average 4.6 months later. Comparison was made with 58 age-matched (79 +/- 5 years) women. Women with hip fracture had initially 30% lower Oc levels compared to the controls (p = 0.0001). The Oc level was independent of time elapsed from trauma, within 18 h, after which the level further decreased. At follow-up, Oc showed a 44% increase (p = 0.0001) and had reached the level of the controls, but not beyond it. A concomitant, but less marked increase was noted for alkaline phosphatase (ALP) (p = 0.0001). We conclude that although the bone formation, as assessed by Oc, is apparently lower in elderly women who sustain a hip fracture, the ability to induce a fracture response, with an increased bone turnover during fracture healing is intact. Subsequently, it is essential that a time perspective is applied, as the bone metabolic changes in patients having sustained a fracture are related to the time elapsed from fracture.},
  author       = {Åkesson, Kristina and Vergnaud, P and Delmas, P D and Obrant, Karl},
  issn         = {1873-2763},
  language     = {eng},
  number       = {4},
  pages        = {427--430},
  publisher    = {Elsevier},
  series       = {Bone},
  title        = {Serum osteocalcin increases during fracture healing in elderly women with hip fracture},
  url          = {http://dx.doi.org/10.1016/8756-3282(95)90187-6},
  volume       = {16},
  year         = {1995},
}