Preoperative grading of glioma malignancy with thallium-201 single-photon emission CT: comparison with conventional CT
(1996) In AJNR 17(5). p.925-932- Abstract
- PURPOSE: To compare thallium-201 single-photon emission CT with conventional CT in grading the malignancy of gliomas and to determine the reliability of each in tumor assessment. METHODS: We studied 37 patients who had gliomas (31 high grade and 6 low grade) and compared the CT findings with the thallium-201 index, which we defined as tumor uptake relative to the uptake in the contralateral hemisphere. RESULTS: Among the high-grade gliomas, we observed a significant correlation between breakdown volume of the blood-brain barrier and thallium-201 uptake. However, 8 of the high-grade gliomas had low thallium-201 uptake, in the same range as the low-grade gliomas. Of these, 2 were nonenhancing and the other 6 showed ring enhancement on CT... (More)
- PURPOSE: To compare thallium-201 single-photon emission CT with conventional CT in grading the malignancy of gliomas and to determine the reliability of each in tumor assessment. METHODS: We studied 37 patients who had gliomas (31 high grade and 6 low grade) and compared the CT findings with the thallium-201 index, which we defined as tumor uptake relative to the uptake in the contralateral hemisphere. RESULTS: Among the high-grade gliomas, we observed a significant correlation between breakdown volume of the blood-brain barrier and thallium-201 uptake. However, 8 of the high-grade gliomas had low thallium-201 uptake, in the same range as the low-grade gliomas. Of these, 2 were nonenhancing and the other 6 showed ring enhancement on CT scans. Analysis of variance showed no significant difference in thallium-201 indexes between low-grade gliomas and highly malignant (grade II-III) gliomas. Accuracy of thallium-201 imaging was lower (78%) than that of CT (84%) in identifying high-grade gliomas. CONCLUSIONS: Damage to the blood-brain barrier is a prerequisite for uptake of thallium-201 in gliomas. Tumors with central necrotic areas and moderate ring enhancement tend to be underestimated when evaluated by means of thallium-201 scintigraphy. The results indicate a need for caution when interpreting findings on images obtained with thallium-201 single-photon emission CT in preoperative evaluation of brain tumors. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1110122
- author
- Källén, Kristina LU ; Heiling, M ; Andersson, A M ; Brun, Arne LU ; Holtås, Stig LU and Ryding, Erik LU
- organization
- publishing date
- 1996
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Glioma, Brain neoplasms, computed tomography, Single-photon emission computed tomography
- in
- AJNR
- volume
- 17
- issue
- 5
- pages
- 925 - 932
- publisher
- American Society of Neuroradiology
- external identifiers
-
- pmid:8733968
- scopus:0029877482
- ISSN
- 1936-959X
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Clinical Neurophysiology (013013001), Diagnostic Radiology, (Lund) (013038000), Neurosurgery (013026000), Pathology, (Lund) (013030000), Neurology, Lund (013027000)
- id
- eedd4d38-eb6a-46d7-971a-9d5003bef72e (old id 1110122)
- alternative location
- http://www.ajnr.org/cgi/content/abstract/17/5/925
- date added to LUP
- 2016-04-01 17:02:51
- date last changed
- 2022-01-29 00:00:59
@article{eedd4d38-eb6a-46d7-971a-9d5003bef72e, abstract = {{PURPOSE: To compare thallium-201 single-photon emission CT with conventional CT in grading the malignancy of gliomas and to determine the reliability of each in tumor assessment. METHODS: We studied 37 patients who had gliomas (31 high grade and 6 low grade) and compared the CT findings with the thallium-201 index, which we defined as tumor uptake relative to the uptake in the contralateral hemisphere. RESULTS: Among the high-grade gliomas, we observed a significant correlation between breakdown volume of the blood-brain barrier and thallium-201 uptake. However, 8 of the high-grade gliomas had low thallium-201 uptake, in the same range as the low-grade gliomas. Of these, 2 were nonenhancing and the other 6 showed ring enhancement on CT scans. Analysis of variance showed no significant difference in thallium-201 indexes between low-grade gliomas and highly malignant (grade II-III) gliomas. Accuracy of thallium-201 imaging was lower (78%) than that of CT (84%) in identifying high-grade gliomas. CONCLUSIONS: Damage to the blood-brain barrier is a prerequisite for uptake of thallium-201 in gliomas. Tumors with central necrotic areas and moderate ring enhancement tend to be underestimated when evaluated by means of thallium-201 scintigraphy. The results indicate a need for caution when interpreting findings on images obtained with thallium-201 single-photon emission CT in preoperative evaluation of brain tumors.}}, author = {{Källén, Kristina and Heiling, M and Andersson, A M and Brun, Arne and Holtås, Stig and Ryding, Erik}}, issn = {{1936-959X}}, keywords = {{Glioma; Brain neoplasms; computed tomography; Single-photon emission computed tomography}}, language = {{eng}}, number = {{5}}, pages = {{925--932}}, publisher = {{American Society of Neuroradiology}}, series = {{AJNR}}, title = {{Preoperative grading of glioma malignancy with thallium-201 single-photon emission CT: comparison with conventional CT}}, url = {{http://www.ajnr.org/cgi/content/abstract/17/5/925}}, volume = {{17}}, year = {{1996}}, }