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Preoperative grading of glioma malignancy with thallium-201 single-photon emission CT: comparison with conventional CT

Källén, Kristina LU ; Heiling, M; Andersson, A M; Brun, Arne LU ; Holtås, Stig LU and Ryding, Erik LU (1996) In AJNR 17(5). p.925-932
Abstract
PURPOSE: To compare thallium-201 single-photon emission CT with conventional CT in grading the malignancy of gliomas and to determine the reliability of each in tumor assessment. METHODS: We studied 37 patients who had gliomas (31 high grade and 6 low grade) and compared the CT findings with the thallium-201 index, which we defined as tumor uptake relative to the uptake in the contralateral hemisphere. RESULTS: Among the high-grade gliomas, we observed a significant correlation between breakdown volume of the blood-brain barrier and thallium-201 uptake. However, 8 of the high-grade gliomas had low thallium-201 uptake, in the same range as the low-grade gliomas. Of these, 2 were nonenhancing and the other 6 showed ring enhancement on CT... (More)
PURPOSE: To compare thallium-201 single-photon emission CT with conventional CT in grading the malignancy of gliomas and to determine the reliability of each in tumor assessment. METHODS: We studied 37 patients who had gliomas (31 high grade and 6 low grade) and compared the CT findings with the thallium-201 index, which we defined as tumor uptake relative to the uptake in the contralateral hemisphere. RESULTS: Among the high-grade gliomas, we observed a significant correlation between breakdown volume of the blood-brain barrier and thallium-201 uptake. However, 8 of the high-grade gliomas had low thallium-201 uptake, in the same range as the low-grade gliomas. Of these, 2 were nonenhancing and the other 6 showed ring enhancement on CT scans. Analysis of variance showed no significant difference in thallium-201 indexes between low-grade gliomas and highly malignant (grade II-III) gliomas. Accuracy of thallium-201 imaging was lower (78%) than that of CT (84%) in identifying high-grade gliomas. CONCLUSIONS: Damage to the blood-brain barrier is a prerequisite for uptake of thallium-201 in gliomas. Tumors with central necrotic areas and moderate ring enhancement tend to be underestimated when evaluated by means of thallium-201 scintigraphy. The results indicate a need for caution when interpreting findings on images obtained with thallium-201 single-photon emission CT in preoperative evaluation of brain tumors. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Glioma, Brain neoplasms, computed tomography, Single-photon emission computed tomography
in
AJNR
volume
17
issue
5
pages
925 - 932
publisher
American Society of Neuroradiology
external identifiers
  • pmid:8733968
  • scopus:0029877482
ISSN
1936-959X
language
English
LU publication?
yes
id
eedd4d38-eb6a-46d7-971a-9d5003bef72e (old id 1110122)
alternative location
http://www.ajnr.org/cgi/content/abstract/17/5/925
date added to LUP
2008-07-24 10:56:37
date last changed
2017-01-01 07:22:44
@article{eedd4d38-eb6a-46d7-971a-9d5003bef72e,
  abstract     = {PURPOSE: To compare thallium-201 single-photon emission CT with conventional CT in grading the malignancy of gliomas and to determine the reliability of each in tumor assessment. METHODS: We studied 37 patients who had gliomas (31 high grade and 6 low grade) and compared the CT findings with the thallium-201 index, which we defined as tumor uptake relative to the uptake in the contralateral hemisphere. RESULTS: Among the high-grade gliomas, we observed a significant correlation between breakdown volume of the blood-brain barrier and thallium-201 uptake. However, 8 of the high-grade gliomas had low thallium-201 uptake, in the same range as the low-grade gliomas. Of these, 2 were nonenhancing and the other 6 showed ring enhancement on CT scans. Analysis of variance showed no significant difference in thallium-201 indexes between low-grade gliomas and highly malignant (grade II-III) gliomas. Accuracy of thallium-201 imaging was lower (78%) than that of CT (84%) in identifying high-grade gliomas. CONCLUSIONS: Damage to the blood-brain barrier is a prerequisite for uptake of thallium-201 in gliomas. Tumors with central necrotic areas and moderate ring enhancement tend to be underestimated when evaluated by means of thallium-201 scintigraphy. The results indicate a need for caution when interpreting findings on images obtained with thallium-201 single-photon emission CT in preoperative evaluation of brain tumors.},
  author       = {Källén, Kristina and Heiling, M and Andersson, A M and Brun, Arne and Holtås, Stig and Ryding, Erik},
  issn         = {1936-959X},
  keyword      = {Glioma,Brain neoplasms,computed tomography,Single-photon emission computed
tomography},
  language     = {eng},
  number       = {5},
  pages        = {925--932},
  publisher    = {American Society of Neuroradiology},
  series       = {AJNR},
  title        = {Preoperative grading of glioma malignancy with thallium-201 single-photon emission CT: comparison with conventional CT},
  volume       = {17},
  year         = {1996},
}