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Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS

Åman, Pierre; Panagopoulos, Ioannis LU ; Lassen, Carin LU ; Fioretos, Thoas LU ; Mencinger, Marina; Toresson, Håkan LU ; Höglund, Mattias LU ; Forster, Allan; Rabbitts, Terence H. and Ron, David, et al. (1996) In Genomics 37(1). p.1-8
Abstract
FUS (TLS) was first identified as the 5'-part of a fusion gene with CHOP (GADD153, DDIT3) in myxoid liposarcomas with t(12; 16)(q13; p11). Homologies were found with the EWS oncogene, which is rearranged in Ewing sarcomas and other neoplasias. The genomic structure of FUS shows extensive similarities with that of EWS, but the exon/intron structures differ in the 5' parts, and overall FUS is smaller than EWS. Exon 3 of FUS corresponds to exons 3 and 4 in EWS. FUS exons 4-6 correspond to EWS exons 5-8. Exons 7 to 15 of FUS are very similar to those in EWS, although the EWS exons are larger than the corresponding FUS exons. FUS and EWS were expressed in all tissues investigated. The transcripts were stable within the 160-min half-life... (More)
FUS (TLS) was first identified as the 5'-part of a fusion gene with CHOP (GADD153, DDIT3) in myxoid liposarcomas with t(12; 16)(q13; p11). Homologies were found with the EWS oncogene, which is rearranged in Ewing sarcomas and other neoplasias. The genomic structure of FUS shows extensive similarities with that of EWS, but the exon/intron structures differ in the 5' parts, and overall FUS is smaller than EWS. Exon 3 of FUS corresponds to exons 3 and 4 in EWS. FUS exons 4-6 correspond to EWS exons 5-8. Exons 7 to 15 of FUS are very similar to those in EWS, although the EWS exons are larger than the corresponding FUS exons. FUS and EWS were expressed in all tissues investigated. The transcripts were stable within the 160-min half-life experiments. No or little variation in FUS or EWS expression was seen when resting lymphocytes were activated. These observations indicate that FUS and EWS belong to the housekeeping type of genes. This view is supported by the presence of the housekeeping gene type of promoter region in both genes. (Less)
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Genomics
volume
37
issue
1
pages
1 - 8
publisher
Academic Press
external identifiers
  • pmid:8921363
  • scopus:0030272143
ISSN
1089-8646
DOI
10.1006/geno.1996.0513
language
English
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yes
id
52cd9ee9-6bb7-4614-b355-8b660d9de7da (old id 1110603)
date added to LUP
2008-07-21 09:46:27
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2017-10-22 03:44:24
@article{52cd9ee9-6bb7-4614-b355-8b660d9de7da,
  abstract     = {FUS (TLS) was first identified as the 5'-part of a fusion gene with CHOP (GADD153, DDIT3) in myxoid liposarcomas with t(12; 16)(q13; p11). Homologies were found with the EWS oncogene, which is rearranged in Ewing sarcomas and other neoplasias. The genomic structure of FUS shows extensive similarities with that of EWS, but the exon/intron structures differ in the 5' parts, and overall FUS is smaller than EWS. Exon 3 of FUS corresponds to exons 3 and 4 in EWS. FUS exons 4-6 correspond to EWS exons 5-8. Exons 7 to 15 of FUS are very similar to those in EWS, although the EWS exons are larger than the corresponding FUS exons. FUS and EWS were expressed in all tissues investigated. The transcripts were stable within the 160-min half-life experiments. No or little variation in FUS or EWS expression was seen when resting lymphocytes were activated. These observations indicate that FUS and EWS belong to the housekeeping type of genes. This view is supported by the presence of the housekeeping gene type of promoter region in both genes.},
  author       = {Åman, Pierre and Panagopoulos, Ioannis and Lassen, Carin and Fioretos, Thoas and Mencinger, Marina and Toresson, Håkan and Höglund, Mattias and Forster, Allan and Rabbitts, Terence H. and Ron, David and Mandahl, Nils and Mitelman, Felix},
  issn         = {1089-8646},
  language     = {eng},
  number       = {1},
  pages        = {1--8},
  publisher    = {Academic Press},
  series       = {Genomics},
  title        = {Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS},
  url          = {http://dx.doi.org/10.1006/geno.1996.0513},
  volume       = {37},
  year         = {1996},
}