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The role of macrophages in bioartificial nerve grafts based on resorbable guiding filament structures

Terada, N; Bjursten, Lars Magnus LU and Lundborg, Göran LU (1997) In Journal of Materials Science: Materials in Medicine 8(6). p.391-394
Abstract
A 10 mm gap in a rat sciatic nerve was bridged by a bioartificial nerve graft consisting of a silicone tube containing seven longitudinally placed filaments made of non-resorbable material (polyamide [Ethilon]) or resorbable materials (polydioxanon [PDS], polyglactin [Vicryl] or catgut). The purpose was to study the tissue reaction induced by the four different types of materials. At 4 weeks an immunocytochemical technique, using ED1 and ED2 monoclonal antibodies, was used to study the presence and location of macrophages. A large number of macrophages were found accumulating on the surface of catgut and polyglactin, while few were found on the surface of polyamide and polydioxanon filaments. It is concluded that the cell layers on the... (More)
A 10 mm gap in a rat sciatic nerve was bridged by a bioartificial nerve graft consisting of a silicone tube containing seven longitudinally placed filaments made of non-resorbable material (polyamide [Ethilon]) or resorbable materials (polydioxanon [PDS], polyglactin [Vicryl] or catgut). The purpose was to study the tissue reaction induced by the four different types of materials. At 4 weeks an immunocytochemical technique, using ED1 and ED2 monoclonal antibodies, was used to study the presence and location of macrophages. A large number of macrophages were found accumulating on the surface of catgut and polyglactin, while few were found on the surface of polyamide and polydioxanon filaments. It is concluded that the cell layers on the filament surface mainly consisted of ED1 positive cells and their thickness depends on the filament materials. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Materials Science: Materials in Medicine
volume
8
issue
6
pages
391 - 394
publisher
Kluwer
external identifiers
  • pmid:15348742
  • scopus:0031172473
ISSN
1573-4838
DOI
10.1023/A:1018593219113
language
English
LU publication?
yes
id
f727f274-77ad-4e7d-8a9d-ad69e36a260d (old id 1111337)
date added to LUP
2008-07-17 11:32:19
date last changed
2017-08-20 04:23:34
@article{f727f274-77ad-4e7d-8a9d-ad69e36a260d,
  abstract     = {A 10 mm gap in a rat sciatic nerve was bridged by a bioartificial nerve graft consisting of a silicone tube containing seven longitudinally placed filaments made of non-resorbable material (polyamide [Ethilon]) or resorbable materials (polydioxanon [PDS], polyglactin [Vicryl] or catgut). The purpose was to study the tissue reaction induced by the four different types of materials. At 4 weeks an immunocytochemical technique, using ED1 and ED2 monoclonal antibodies, was used to study the presence and location of macrophages. A large number of macrophages were found accumulating on the surface of catgut and polyglactin, while few were found on the surface of polyamide and polydioxanon filaments. It is concluded that the cell layers on the filament surface mainly consisted of ED1 positive cells and their thickness depends on the filament materials.},
  author       = {Terada, N and Bjursten, Lars Magnus and Lundborg, Göran},
  issn         = {1573-4838},
  language     = {eng},
  number       = {6},
  pages        = {391--394},
  publisher    = {Kluwer},
  series       = {Journal of Materials Science: Materials in Medicine},
  title        = {The role of macrophages in bioartificial nerve grafts based on resorbable guiding filament structures},
  url          = {http://dx.doi.org/10.1023/A:1018593219113},
  volume       = {8},
  year         = {1997},
}