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Bioartificial nerve grafts based on absorbable guiding filament structures--early observations

Terada, Nobuki; Bjursten, Lars Magnus LU ; Dohi, Daisuke and Lundborg, Göran LU (1997) In Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery 31(1). p.1-6
Abstract
Gaps 10 mm wide in the sciatic nerves of 64 rats were bridged by bioartificial nerve grafts consisting of a silicone tube containing seven longitudinally placed filaments made of non-absorbable, (polyamide [Ethilon]) or absorbable, material (polydioxanone [PDS], polyglactin [Vicryl], and catgut). The purpose was to study the organisation of axonal growth inside the tube along such filaments. After two and four weeks histological techniques were used to study the contents of the tube and at four weeks immunohistological techniques were used to confirm the presence of axons distal to the tube. In all experimental groups axons had traversed the tube and reached the distal segment after four weeks. Inside the tube axons were organised in... (More)
Gaps 10 mm wide in the sciatic nerves of 64 rats were bridged by bioartificial nerve grafts consisting of a silicone tube containing seven longitudinally placed filaments made of non-absorbable, (polyamide [Ethilon]) or absorbable, material (polydioxanone [PDS], polyglactin [Vicryl], and catgut). The purpose was to study the organisation of axonal growth inside the tube along such filaments. After two and four weeks histological techniques were used to study the contents of the tube and at four weeks immunohistological techniques were used to confirm the presence of axons distal to the tube. In all experimental groups axons had traversed the tube and reached the distal segment after four weeks. Inside the tube axons were organised in multiple minifascicles in all groups, but there were no axons growing in direct contact with the filaments. We conclude that resorbable filaments placed inside a silicone tube do not disturb axonal growth across the tube. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
nerve regeneration, axonal growth, nerve graft, silicone chamber, resorbable filament, biomaterial
in
Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
volume
31
issue
1
pages
1 - 6
publisher
Taylor & Francis
external identifiers
  • pmid:9075281
  • scopus:0031042958
ISSN
1651-2073
DOI
10.3109/02844319709010498
language
English
LU publication?
yes
id
5b26e219-c7f0-4f16-960b-cc1caf1a6f2f (old id 1111340)
date added to LUP
2008-07-17 11:36:27
date last changed
2017-08-20 04:18:47
@article{5b26e219-c7f0-4f16-960b-cc1caf1a6f2f,
  abstract     = {Gaps 10 mm wide in the sciatic nerves of 64 rats were bridged by bioartificial nerve grafts consisting of a silicone tube containing seven longitudinally placed filaments made of non-absorbable, (polyamide [Ethilon]) or absorbable, material (polydioxanone [PDS], polyglactin [Vicryl], and catgut). The purpose was to study the organisation of axonal growth inside the tube along such filaments. After two and four weeks histological techniques were used to study the contents of the tube and at four weeks immunohistological techniques were used to confirm the presence of axons distal to the tube. In all experimental groups axons had traversed the tube and reached the distal segment after four weeks. Inside the tube axons were organised in multiple minifascicles in all groups, but there were no axons growing in direct contact with the filaments. We conclude that resorbable filaments placed inside a silicone tube do not disturb axonal growth across the tube.},
  author       = {Terada, Nobuki and Bjursten, Lars Magnus and Dohi, Daisuke and Lundborg, Göran},
  issn         = {1651-2073},
  keyword      = {nerve regeneration,axonal growth,nerve graft,silicone chamber,resorbable filament,biomaterial},
  language     = {eng},
  number       = {1},
  pages        = {1--6},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery},
  title        = {Bioartificial nerve grafts based on absorbable guiding filament structures--early observations},
  url          = {http://dx.doi.org/10.3109/02844319709010498},
  volume       = {31},
  year         = {1997},
}