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Identification of TP53 gene mutations in uterine corpus cancer with short follow-up

Koul, Anjila LU ; Borg, Åke LU ; Pejovic, Tanja; Bendahl, Pär-Ola LU ; Högberg, Thomas LU ; Iosif, Constantin LU and Killander, Dick LU (1997) In Gynecologic Oncology 67(3). p.295-302
Abstract
The involvement of the TP53 tumor suppressor gene in uterine corpus cancer was investigated by single-stranded conformation polymorphism and sequence analysis of its exons 4 to 10. Mutations were found in 12 (18.5%) of 65 cases. Ten of these 12 were single-base substitutions (8 missense and 2 nonsense mutations), whereas 2 were frame-shifting mutations. TP53 gene mutations correlated significantly with advanced surgical stage of disease (P = 0.006) and unfavorable tumor histology types (P = 0.003), whereas the association to myometrial wall invasion did not reach statistical significance (P = 0.054). TP53 gene mutations also correlated significantly with allelic loss at TP53 locus (P = 0.024), absence of estrogen (P = 0.045) and... (More)
The involvement of the TP53 tumor suppressor gene in uterine corpus cancer was investigated by single-stranded conformation polymorphism and sequence analysis of its exons 4 to 10. Mutations were found in 12 (18.5%) of 65 cases. Ten of these 12 were single-base substitutions (8 missense and 2 nonsense mutations), whereas 2 were frame-shifting mutations. TP53 gene mutations correlated significantly with advanced surgical stage of disease (P = 0.006) and unfavorable tumor histology types (P = 0.003), whereas the association to myometrial wall invasion did not reach statistical significance (P = 0.054). TP53 gene mutations also correlated significantly with allelic loss at TP53 locus (P = 0.024), absence of estrogen (P = 0.045) and progesterone receptors (P = 0.001), DNA nondiploidy (P = 0.002), and high S-phase fraction values (P = 0.002). Our results suggest that inactivation of the TP53 checkpoint function is associated with disease transition into a stage of rapid progression and spread. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
TP53, mutation, uterine corpus cancer, DNA ploidy
in
Gynecologic Oncology
volume
67
issue
3
pages
295 - 302
publisher
Academic Press
external identifiers
  • pmid:9441778
  • scopus:0031439934
ISSN
1095-6859
DOI
10.1006/gyno.1997.4859
language
English
LU publication?
yes
id
603a6656-cd6e-490d-b7e1-f1dd38057c6f (old id 1111538)
date added to LUP
2008-07-17 15:54:38
date last changed
2017-01-01 04:45:05
@article{603a6656-cd6e-490d-b7e1-f1dd38057c6f,
  abstract     = {The involvement of the TP53 tumor suppressor gene in uterine corpus cancer was investigated by single-stranded conformation polymorphism and sequence analysis of its exons 4 to 10. Mutations were found in 12 (18.5%) of 65 cases. Ten of these 12 were single-base substitutions (8 missense and 2 nonsense mutations), whereas 2 were frame-shifting mutations. TP53 gene mutations correlated significantly with advanced surgical stage of disease (P = 0.006) and unfavorable tumor histology types (P = 0.003), whereas the association to myometrial wall invasion did not reach statistical significance (P = 0.054). TP53 gene mutations also correlated significantly with allelic loss at TP53 locus (P = 0.024), absence of estrogen (P = 0.045) and progesterone receptors (P = 0.001), DNA nondiploidy (P = 0.002), and high S-phase fraction values (P = 0.002). Our results suggest that inactivation of the TP53 checkpoint function is associated with disease transition into a stage of rapid progression and spread.},
  author       = {Koul, Anjila and Borg, Åke and Pejovic, Tanja and Bendahl, Pär-Ola and Högberg, Thomas and Iosif, Constantin and Killander, Dick},
  issn         = {1095-6859},
  keyword      = {TP53,mutation,uterine corpus cancer,DNA ploidy},
  language     = {eng},
  number       = {3},
  pages        = {295--302},
  publisher    = {Academic Press},
  series       = {Gynecologic Oncology},
  title        = {Identification of TP53 gene mutations in uterine corpus cancer with short follow-up},
  url          = {http://dx.doi.org/10.1006/gyno.1997.4859},
  volume       = {67},
  year         = {1997},
}