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Use of k-space segmentation in MR velocity mapping for rapid quantification of CSF flow

Ståhlberg, Freddy LU ; Nitz, Wolfgang; Nilsson, Christer LU and Holtås, Stig LU (1997) In Journal of Magnetic Resonance Imaging 7(6). p.972-978
Abstract
In this work, a k-space segmentation technique for quantitative studies of pulsatile cerebrospinal fluid (CSF) flow is suggested. Three k-space lines are sampled for each of two interleaved gradient-echo sequences (velocity-compensated and velocity-encoded) within each repetition interval. Nine cardiac phases are obtained at a heart rate of 60 bpm with maintained nominal resolution and a factor of 3 in reduction of acquisition time relative to our conventional nonsegmented flow quantification protocol. Segmented and conventional sequences were compared in phantoms, in healthy volunteers, and in two patients with clinically suspected normal pressure hydrocephalus. Good agreement between flow curves obtained with the two sequences was... (More)
In this work, a k-space segmentation technique for quantitative studies of pulsatile cerebrospinal fluid (CSF) flow is suggested. Three k-space lines are sampled for each of two interleaved gradient-echo sequences (velocity-compensated and velocity-encoded) within each repetition interval. Nine cardiac phases are obtained at a heart rate of 60 bpm with maintained nominal resolution and a factor of 3 in reduction of acquisition time relative to our conventional nonsegmented flow quantification protocol. Segmented and conventional sequences were compared in phantoms, in healthy volunteers, and in two patients with clinically suspected normal pressure hydrocephalus. Good agreement between flow curves obtained with the two sequences was demonstrated in vitro as well as in vivo. A slight underestimation of flow values in volunteers was attributed to data filtering when using the segmented sequence. Because the CSF circulation is complex and tightly connected to the vascular circulation, specific clinical applications may require flow studies at multiple positions and with different velocity encoding. In such cases, the proposed sequence can be used to gain time, but alternatively, the segmentation technique can be used to further increase spatial resolution within reasonable examination times. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
MRI, Flow, Quantification, Cerebrospinal fluid, Fast imaging
in
Journal of Magnetic Resonance Imaging
volume
7
issue
6
pages
972 - 978
publisher
John Wiley & Sons
external identifiers
  • pmid:9400839
  • scopus:0031397673
ISSN
1522-2586
DOI
10.1002/jmri.1880070607
language
English
LU publication?
yes
id
0b27a0d4-467f-4931-b9cc-4443d27a7fae (old id 1111619)
date added to LUP
2008-07-18 09:26:19
date last changed
2017-01-01 05:02:02
@article{0b27a0d4-467f-4931-b9cc-4443d27a7fae,
  abstract     = {In this work, a k-space segmentation technique for quantitative studies of pulsatile cerebrospinal fluid (CSF) flow is suggested. Three k-space lines are sampled for each of two interleaved gradient-echo sequences (velocity-compensated and velocity-encoded) within each repetition interval. Nine cardiac phases are obtained at a heart rate of 60 bpm with maintained nominal resolution and a factor of 3 in reduction of acquisition time relative to our conventional nonsegmented flow quantification protocol. Segmented and conventional sequences were compared in phantoms, in healthy volunteers, and in two patients with clinically suspected normal pressure hydrocephalus. Good agreement between flow curves obtained with the two sequences was demonstrated in vitro as well as in vivo. A slight underestimation of flow values in volunteers was attributed to data filtering when using the segmented sequence. Because the CSF circulation is complex and tightly connected to the vascular circulation, specific clinical applications may require flow studies at multiple positions and with different velocity encoding. In such cases, the proposed sequence can be used to gain time, but alternatively, the segmentation technique can be used to further increase spatial resolution within reasonable examination times.},
  author       = {Ståhlberg, Freddy and Nitz, Wolfgang and Nilsson, Christer and Holtås, Stig},
  issn         = {1522-2586},
  keyword      = {MRI,Flow,Quantification,Cerebrospinal fluid,Fast imaging},
  language     = {eng},
  number       = {6},
  pages        = {972--978},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Magnetic Resonance Imaging},
  title        = {Use of k-space segmentation in MR velocity mapping for rapid quantification of CSF flow},
  url          = {http://dx.doi.org/10.1002/jmri.1880070607},
  volume       = {7},
  year         = {1997},
}