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Pharmacokinetics of Na2B12H11SH (BSH) in patients with malignant brain tumours as prerequisite for a phase I clinical trial of boron neutron capture

Gabel, D; Preusse, D; Haritz, D; Grochulla, F; Haselsberger, K; Fankhauser, H; Ceberg, Crister LU ; Peters, H D and Klotz, U (1997) In Acta Neurochirurgica 139(7). p.606-612
Abstract
The disposition of Na2B12H11SH (BSH) in patients with malignant glioma has been investigated, in preparation for a Phase I clinical trial of boron neutron capture therapy. BSH was found to possess a linear disposition over the dosage interval investigated (up to 75 mg/kg). A bi-phasic blood pharmacokinetics was observed. Tumour-to-blood ratios showed variations between patients between 0.08 and 5.1. The data allow the definition of amount of BSH and timing of infusion for a Phase I clinical trial protocol.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Boron neutron capture therapy, glioma, BSH
in
Acta Neurochirurgica
volume
139
issue
7
pages
606 - 612
publisher
Springer
external identifiers
  • pmid:9265952
  • scopus:0030752312
ISSN
0001-6268
DOI
10.1007/BF01411994
language
English
LU publication?
yes
id
13ef977a-5e03-417b-854d-7363405d0f12 (old id 1112148)
date added to LUP
2008-07-21 13:56:55
date last changed
2017-07-30 04:44:27
@article{13ef977a-5e03-417b-854d-7363405d0f12,
  abstract     = {The disposition of Na2B12H11SH (BSH) in patients with malignant glioma has been investigated, in preparation for a Phase I clinical trial of boron neutron capture therapy. BSH was found to possess a linear disposition over the dosage interval investigated (up to 75 mg/kg). A bi-phasic blood pharmacokinetics was observed. Tumour-to-blood ratios showed variations between patients between 0.08 and 5.1. The data allow the definition of amount of BSH and timing of infusion for a Phase I clinical trial protocol.},
  author       = {Gabel, D and Preusse, D and Haritz, D and Grochulla, F and Haselsberger, K and Fankhauser, H and Ceberg, Crister and Peters, H D and Klotz, U},
  issn         = {0001-6268},
  keyword      = {Boron neutron capture therapy,glioma,BSH},
  language     = {eng},
  number       = {7},
  pages        = {606--612},
  publisher    = {Springer},
  series       = {Acta Neurochirurgica},
  title        = {Pharmacokinetics of Na2B12H11SH (BSH) in patients with malignant brain tumours as prerequisite for a phase I clinical trial of boron neutron capture},
  url          = {http://dx.doi.org/10.1007/BF01411994},
  volume       = {139},
  year         = {1997},
}