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5-Hydroxytryptamine contracts human uterine artery smooth muscle predominantly via 5-HT2 receptors

Karlsson, Caroline LU ; Bodelsson, Gunilla LU ; Bodelsson, Mikael LU and Stjernquist, Martin LU (1997) In Human Reproduction 12(2). p.361-367
Abstract
Serotonergic receptors were classified in the isolated human uterine artery with intact endothelium, using agonists and antagonists for 5-hydroxytryptamine (5-HT) receptors. The efficacy for different agonists rated: alpha-methyl-5-HT (5-HT2) = 5-HT (non-selective) = 2-methyl-5-HT (5-HT3) >> sumatriptan (5-HT1), and the potency as: sumatriptan = 5-HT > 5-HT > alpha-methyl-5-HT > 2-methyl-5-HT. The contractile effects of 5-HT and alpha-methyl-5-HT were antagonized by the 5-HT2 receptor antagonist ketanserin and the non-selective antagonist methiothepin. The efficacy of sumatriptan was comparatively low. No interaction was encountered between 2-methyl-5-HT and MDL72222, suggesting an absence of 5-HT3 receptors. The results... (More)
Serotonergic receptors were classified in the isolated human uterine artery with intact endothelium, using agonists and antagonists for 5-hydroxytryptamine (5-HT) receptors. The efficacy for different agonists rated: alpha-methyl-5-HT (5-HT2) = 5-HT (non-selective) = 2-methyl-5-HT (5-HT3) >> sumatriptan (5-HT1), and the potency as: sumatriptan = 5-HT > 5-HT > alpha-methyl-5-HT > 2-methyl-5-HT. The contractile effects of 5-HT and alpha-methyl-5-HT were antagonized by the 5-HT2 receptor antagonist ketanserin and the non-selective antagonist methiothepin. The efficacy of sumatriptan was comparatively low. No interaction was encountered between 2-methyl-5-HT and MDL72222, suggesting an absence of 5-HT3 receptors. The results indicate that the contractile serotonergic receptor population in the human uterine artery mainly comprises 5-HT2 receptors, although a minor contribution of contractile 5-HT1 receptors cannot be excluded. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
keywords
5-HT (5-hydroxytryptamine, serotonin)/5-HT properties and linked second messenger systems, the 5-HT receptors/smooth muscle/uterine artery (human)
in
Human Reproduction
volume
12
issue
2
pages
361 - 367
publisher
Oxford University Press
external identifiers
  • pmid:9070726
  • scopus:0030993824
ISSN
0268-1161
language
English
LU publication?
yes
id
b79672f5-2067-481b-9c9d-1544dbe9b27f (old id 1112382)
alternative location
http://humrep.oxfordjournals.org/cgi/reprint/12/2/361
date added to LUP
2008-07-22 10:27:22
date last changed
2017-08-13 03:46:53
@article{b79672f5-2067-481b-9c9d-1544dbe9b27f,
  abstract     = {Serotonergic receptors were classified in the isolated human uterine artery with intact endothelium, using agonists and antagonists for 5-hydroxytryptamine (5-HT) receptors. The efficacy for different agonists rated: alpha-methyl-5-HT (5-HT2) = 5-HT (non-selective) = 2-methyl-5-HT (5-HT3) >> sumatriptan (5-HT1), and the potency as: sumatriptan = 5-HT > 5-HT > alpha-methyl-5-HT > 2-methyl-5-HT. The contractile effects of 5-HT and alpha-methyl-5-HT were antagonized by the 5-HT2 receptor antagonist ketanserin and the non-selective antagonist methiothepin. The efficacy of sumatriptan was comparatively low. No interaction was encountered between 2-methyl-5-HT and MDL72222, suggesting an absence of 5-HT3 receptors. The results indicate that the contractile serotonergic receptor population in the human uterine artery mainly comprises 5-HT2 receptors, although a minor contribution of contractile 5-HT1 receptors cannot be excluded.},
  author       = {Karlsson, Caroline and Bodelsson, Gunilla and Bodelsson, Mikael and Stjernquist, Martin},
  issn         = {0268-1161},
  keyword      = {5-HT (5-hydroxytryptamine,serotonin)/5-HT properties and linked second messenger systems,the 5-HT
receptors/smooth muscle/uterine artery (human)},
  language     = {eng},
  number       = {2},
  pages        = {361--367},
  publisher    = {Oxford University Press},
  series       = {Human Reproduction},
  title        = {5-Hydroxytryptamine contracts human uterine artery smooth muscle predominantly via 5-HT2 receptors},
  volume       = {12},
  year         = {1997},
}