MRI thermometry in phantoms by use of the proton resonance frequency shift method: application to interstitial laser thermotherapy
Olsrud, Johan LU ; Wirestam, Ronnie LU
; Brockstedt, Sara
LU
; Nilsson, Annika M K
; Tranberg, Karl-Göran
LU
; Ståhlberg, Freddy
LU
and Persson, Bertil R
LU
(1998)
In Physics in Medicine and Biology
43(9).
p.2597-2613
- Abstract
- In this work the temperature dependence of the proton resonance frequency was assessed in agarose gel with a high melting temperature (95 degrees C) and in porcine liver in vitro at temperatures relevant to thermotherapy (25-80 degrees C). Furthermore, an optically tissue-like agarose gel phantom was developed and evaluated for use in MRI. The phantom was used to visualize temperature distributions from a diffusing laser fibre by means of the proton resonance frequency shift method. An approximately linear relationship (0.0085 ppm degrees C(-1)) between proton resonance frequency shift and temperature change was found for agarose gel, whereas deviations from a linear relationship were observed for porcine liver. The optically tissue-like... (More)
- In this work the temperature dependence of the proton resonance frequency was assessed in agarose gel with a high melting temperature (95 degrees C) and in porcine liver in vitro at temperatures relevant to thermotherapy (25-80 degrees C). Furthermore, an optically tissue-like agarose gel phantom was developed and evaluated for use in MRI. The phantom was used to visualize temperature distributions from a diffusing laser fibre by means of the proton resonance frequency shift method. An approximately linear relationship (0.0085 ppm degrees C(-1)) between proton resonance frequency shift and temperature change was found for agarose gel, whereas deviations from a linear relationship were observed for porcine liver. The optically tissue-like agarose gel allowed reliable MRI temperature monitoring, and the MR relaxation times (T1 and T2) and the optical properties were found to be independently alterable. Temperature distributions around a diffusing laser fibre, during irradiation and subsequent cooling, were assessed with high spatial resolution (voxel size = 4.3 mm3) and with random uncertainties ranging from 0.3 degrees C to 1.4 degrees C (1 SD) with a 40 s scan time. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1112693
- author
- Olsrud, Johan
LU
; Wirestam, Ronnie
LU
; Brockstedt, Sara
LU
; Nilsson, Annika M K
; Tranberg, Karl-Göran
LU
; Ståhlberg, Freddy
LU
and Persson, Bertil R
LU
- organization
- publishing date
- 1998
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physics in Medicine and Biology
- volume
- 43
- issue
- 9
- pages
- 2597 - 2613
- publisher
- IOP Publishing
- external identifiers
-
- pmid:9755948
- scopus:0031716008
- ISSN
- 1361-6560
- language
- English
- LU publication?
- yes
- id
- ff32db22-5698-4672-ab1d-57f8b9a536a7 (old id 1112693)
- alternative location
- http://www.iop.org/EJ/article/0031-9155/43/9/012/m80912.pdf
- date added to LUP
- 2016-04-01 12:07:12
- date last changed
- 2022-01-26 23:03:03
@article{ff32db22-5698-4672-ab1d-57f8b9a536a7,
abstract = {{In this work the temperature dependence of the proton resonance frequency was assessed in agarose gel with a high melting temperature (95 degrees C) and in porcine liver in vitro at temperatures relevant to thermotherapy (25-80 degrees C). Furthermore, an optically tissue-like agarose gel phantom was developed and evaluated for use in MRI. The phantom was used to visualize temperature distributions from a diffusing laser fibre by means of the proton resonance frequency shift method. An approximately linear relationship (0.0085 ppm degrees C(-1)) between proton resonance frequency shift and temperature change was found for agarose gel, whereas deviations from a linear relationship were observed for porcine liver. The optically tissue-like agarose gel allowed reliable MRI temperature monitoring, and the MR relaxation times (T1 and T2) and the optical properties were found to be independently alterable. Temperature distributions around a diffusing laser fibre, during irradiation and subsequent cooling, were assessed with high spatial resolution (voxel size = 4.3 mm3) and with random uncertainties ranging from 0.3 degrees C to 1.4 degrees C (1 SD) with a 40 s scan time.}},
author = {{Olsrud, Johan and Wirestam, Ronnie and Brockstedt, Sara and Nilsson, Annika M K and Tranberg, Karl-Göran and Ståhlberg, Freddy and Persson, Bertil R}},
issn = {{1361-6560}},
language = {{eng}},
number = {{9}},
pages = {{2597--2613}},
publisher = {{IOP Publishing}},
series = {{Physics in Medicine and Biology}},
title = {{MRI thermometry in phantoms by use of the proton resonance frequency shift method: application to interstitial laser thermotherapy}},
url = {{https://lup.lub.lu.se/search/files/2789633/2371692.pdf}},
volume = {{43}},
year = {{1998}},
}