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Analysis of the inflammatory response to titanium and PTFE implants in soft tissue by macrophage phenotype quantification

Rosengren, Agneta LU ; Bjursten, Lars Magnus LU and Danielsen, Nils LU (1998) In Journal of Materials Science: Materials in Medicine 9(7). p.415-420
Abstract
Implants of commercially pure titanium and polytetrafluoroethylene (PTFE) were inserted in the rat abdominal wall for 1, 6 or 12 wk. The foreign body reaction was evaluated by immunohistochemical quantification of monocytes/macrophages and by the thickness of the foreign-body capsule. At all time intervals, the majority of interfacial cells were ED1-positive while ED2-positive cells were localized deeper in the tissue. Neither titanium nor PTFE displayed a significant change in capsule thickness over time. The total cell numbers decreased overtime for both types of material. At 12 wk the PTFE implants, compared to titanium, were surrounded by a significantly thicker reactive capsule with larger total cell numbers. No significant... (More)
Implants of commercially pure titanium and polytetrafluoroethylene (PTFE) were inserted in the rat abdominal wall for 1, 6 or 12 wk. The foreign body reaction was evaluated by immunohistochemical quantification of monocytes/macrophages and by the thickness of the foreign-body capsule. At all time intervals, the majority of interfacial cells were ED1-positive while ED2-positive cells were localized deeper in the tissue. Neither titanium nor PTFE displayed a significant change in capsule thickness over time. The total cell numbers decreased overtime for both types of material. At 12 wk the PTFE implants, compared to titanium, were surrounded by a significantly thicker reactive capsule with larger total cell numbers. No significant differences were seen in the macrophage subset response between the two types of implants. Thus, the present study showed differences between titanium and PTFE at 12 wk but not at earlier time points. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Materials Science: Materials in Medicine
volume
9
issue
7
pages
415 - 420
publisher
Kluwer
external identifiers
  • pmid:15348870
  • scopus:0032128109
ISSN
1573-4838
DOI
10.1023/A:1013239731256
language
English
LU publication?
yes
id
6da1a6ca-79b2-4b24-b12f-085d2453e26e (old id 1112782)
date added to LUP
2008-07-11 11:01:17
date last changed
2017-01-01 07:08:40
@article{6da1a6ca-79b2-4b24-b12f-085d2453e26e,
  abstract     = {Implants of commercially pure titanium and polytetrafluoroethylene (PTFE) were inserted in the rat abdominal wall for 1, 6 or 12 wk. The foreign body reaction was evaluated by immunohistochemical quantification of monocytes/macrophages and by the thickness of the foreign-body capsule. At all time intervals, the majority of interfacial cells were ED1-positive while ED2-positive cells were localized deeper in the tissue. Neither titanium nor PTFE displayed a significant change in capsule thickness over time. The total cell numbers decreased overtime for both types of material. At 12 wk the PTFE implants, compared to titanium, were surrounded by a significantly thicker reactive capsule with larger total cell numbers. No significant differences were seen in the macrophage subset response between the two types of implants. Thus, the present study showed differences between titanium and PTFE at 12 wk but not at earlier time points.},
  author       = {Rosengren, Agneta and Bjursten, Lars Magnus and Danielsen, Nils},
  issn         = {1573-4838},
  language     = {eng},
  number       = {7},
  pages        = {415--420},
  publisher    = {Kluwer},
  series       = {Journal of Materials Science: Materials in Medicine},
  title        = {Analysis of the inflammatory response to titanium and PTFE implants in soft tissue by macrophage phenotype quantification},
  url          = {http://dx.doi.org/10.1023/A:1013239731256},
  volume       = {9},
  year         = {1998},
}