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Immunoadsorption for removal of inhibitors: update on treatments in Malmo-Lund between 1980 and 1995

Freiburghaus, Christian LU ; Berntorp, Erik LU ; Ekman, Maj LU ; Gunnarsson, Margoth LU ; Kjellberg, B M and Nilsson, I M (1998) In Haemophilia 4(1). p.16-20
Abstract
Treatment of severe bleeding and the performance of surgery in haemophilia patients with inhibitors creates severe problems. It is generally agreed that treatment is most effective if circulating levels of factor VIII/IX can be achieved long enough for control of haemostasis. Immunoadsorption with protein A for the removal of inhibitor has improved treatment for patients with initial inhibitor titres too high to neutralize by infusion alone. This is a summary of our experience in Malmo regarding immunoadsorption and haemostasis. A total of 19 applications with immunoadsorption in 10 patients were performed. On all occasions it was possible to eliminate totally the inhibitor or reduce it to low levels that could easily be neutralized with... (More)
Treatment of severe bleeding and the performance of surgery in haemophilia patients with inhibitors creates severe problems. It is generally agreed that treatment is most effective if circulating levels of factor VIII/IX can be achieved long enough for control of haemostasis. Immunoadsorption with protein A for the removal of inhibitor has improved treatment for patients with initial inhibitor titres too high to neutralize by infusion alone. This is a summary of our experience in Malmo regarding immunoadsorption and haemostasis. A total of 19 applications with immunoadsorption in 10 patients were performed. On all occasions it was possible to eliminate totally the inhibitor or reduce it to low levels that could easily be neutralized with factor concentrate. Haemostatic levels of coagulation factors could be maintained for 5-9 days in all but one patient. This period was sufficient to stop ongoing haemorrhage or prevent excessive bleeding at surgical interventions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Haemophilia, factor VIII, factor IX, inhibitors, immunoadsorption
in
Haemophilia
volume
4
issue
1
pages
16 - 20
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • pmid:9873860
  • scopus:0031598270
ISSN
1351-8216
DOI
10.1046/j.1365-2516.1998.00140.x
language
English
LU publication?
yes
id
54248767-f561-4f8a-a2d3-90081ff9e87d (old id 1113245)
date added to LUP
2008-07-14 15:28:10
date last changed
2017-01-01 04:59:12
@article{54248767-f561-4f8a-a2d3-90081ff9e87d,
  abstract     = {Treatment of severe bleeding and the performance of surgery in haemophilia patients with inhibitors creates severe problems. It is generally agreed that treatment is most effective if circulating levels of factor VIII/IX can be achieved long enough for control of haemostasis. Immunoadsorption with protein A for the removal of inhibitor has improved treatment for patients with initial inhibitor titres too high to neutralize by infusion alone. This is a summary of our experience in Malmo regarding immunoadsorption and haemostasis. A total of 19 applications with immunoadsorption in 10 patients were performed. On all occasions it was possible to eliminate totally the inhibitor or reduce it to low levels that could easily be neutralized with factor concentrate. Haemostatic levels of coagulation factors could be maintained for 5-9 days in all but one patient. This period was sufficient to stop ongoing haemorrhage or prevent excessive bleeding at surgical interventions.},
  author       = {Freiburghaus, Christian and Berntorp, Erik and Ekman, Maj and Gunnarsson, Margoth and Kjellberg, B M and Nilsson, I M},
  issn         = {1351-8216},
  keyword      = {Haemophilia,factor VIII,factor IX,inhibitors,immunoadsorption},
  language     = {eng},
  number       = {1},
  pages        = {16--20},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Haemophilia},
  title        = {Immunoadsorption for removal of inhibitors: update on treatments in Malmo-Lund between 1980 and 1995},
  url          = {http://dx.doi.org/10.1046/j.1365-2516.1998.00140.x},
  volume       = {4},
  year         = {1998},
}