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Tissue reactions to polyethylene implants with different surface topography

Rosengren, Agneta LU ; Bjursten, Lars Magnus LU ; Danielsen, Nils LU ; Persson, H and Kober, M (1999) In Journal of Materials Science: Materials in Medicine 10(2). p.75-82
Abstract
This study investigates the importance of implant surface topography on soft tissue response. The tissue response in the rat abdominal wall to discs of low density polyethylene with smooth to coarse surfaces was evaluated after one, six or 12 weeks. Capsule thickness and immunohistochemical quantification of monocytes-macrophages were used as measures. The macrophage specific antibody ED1 was used for identification of newly recruited macrophages and the ED2 antibody for the mature tissue macrophages. The smoother surfaces gave a thicker capsule than the rougher surfaces, and at one week also larger total numbers of cells and ED1 positive macrophages at interface. The capsule thickness increased over time for the smooth and intermediate... (More)
This study investigates the importance of implant surface topography on soft tissue response. The tissue response in the rat abdominal wall to discs of low density polyethylene with smooth to coarse surfaces was evaluated after one, six or 12 weeks. Capsule thickness and immunohistochemical quantification of monocytes-macrophages were used as measures. The macrophage specific antibody ED1 was used for identification of newly recruited macrophages and the ED2 antibody for the mature tissue macrophages. The smoother surfaces gave a thicker capsule than the rougher surfaces, and at one week also larger total numbers of cells and ED1 positive macrophages at interface. The capsule thickness increased over time for the smooth and intermediate surface topographies. In contrast, the cell numbers generally decreased over time. In conclusion, a coarse surface elicited lesser tissue reaction compared with a smooth surface. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Materials Science: Materials in Medicine
volume
10
issue
2
pages
75 - 82
publisher
Kluwer
external identifiers
  • pmid:15347928
  • scopus:0033083888
ISSN
1573-4838
DOI
10.1023/A:1008964819101
language
English
LU publication?
yes
id
3de78707-7b54-4167-9d3f-dfac306f37a3 (old id 1114276)
date added to LUP
2008-07-03 16:07:15
date last changed
2017-11-05 04:24:03
@article{3de78707-7b54-4167-9d3f-dfac306f37a3,
  abstract     = {This study investigates the importance of implant surface topography on soft tissue response. The tissue response in the rat abdominal wall to discs of low density polyethylene with smooth to coarse surfaces was evaluated after one, six or 12 weeks. Capsule thickness and immunohistochemical quantification of monocytes-macrophages were used as measures. The macrophage specific antibody ED1 was used for identification of newly recruited macrophages and the ED2 antibody for the mature tissue macrophages. The smoother surfaces gave a thicker capsule than the rougher surfaces, and at one week also larger total numbers of cells and ED1 positive macrophages at interface. The capsule thickness increased over time for the smooth and intermediate surface topographies. In contrast, the cell numbers generally decreased over time. In conclusion, a coarse surface elicited lesser tissue reaction compared with a smooth surface.},
  author       = {Rosengren, Agneta and Bjursten, Lars Magnus and Danielsen, Nils and Persson, H and Kober, M},
  issn         = {1573-4838},
  language     = {eng},
  number       = {2},
  pages        = {75--82},
  publisher    = {Kluwer},
  series       = {Journal of Materials Science: Materials in Medicine},
  title        = {Tissue reactions to polyethylene implants with different surface topography},
  url          = {http://dx.doi.org/10.1023/A:1008964819101},
  volume       = {10},
  year         = {1999},
}