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A comparison of genome-scans performed in multicase families with systemic lupus erythematosus from different population groups

Johanneson, B; Steinsson, K; Lindqvist, A K; Kristjansdottir, H; Grondal, G; Sandino, S; Tjernström, Fredrik LU ; Sturfelt, Gunnar LU ; Granados-Arriola, J and Alcocer-Varela, J, et al. (1999) In Journal of Autoimmunity 13(1). p.137-141
Abstract
Systemic lupus erythematosus is a disease of unknown etiology. Multiple genetic factors are believed to be involved in its pathogenesis. In addition, and due to genetic heterogeneity, these factors and/or their combinations may be different in different ethnic groups, while some might be shared between populations. We have performed genome scans in multicase families from three different population groups, two from Northern Europe, with a high degree of homogeneity, and the third from a recently admixed population of Mexican Mestizos. Although our family material is relatively small, the results presented here show that using family sets from well defined populations are sufficient to detect susceptibility loci for SLE. Our results also... (More)
Systemic lupus erythematosus is a disease of unknown etiology. Multiple genetic factors are believed to be involved in its pathogenesis. In addition, and due to genetic heterogeneity, these factors and/or their combinations may be different in different ethnic groups, while some might be shared between populations. We have performed genome scans in multicase families from three different population groups, two from Northern Europe, with a high degree of homogeneity, and the third from a recently admixed population of Mexican Mestizos. Although our family material is relatively small, the results presented here show that using family sets from well defined populations are sufficient to detect susceptibility loci for SLE. Our results also reveal the chromosomal regions most likely to contain susceptibility genes for SLE. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
keywords
systemic lupus erythematosus, genetics, autoimmunity, genome-scan, linkage analysis
in
Journal of Autoimmunity
volume
13
issue
1
pages
137 - 141
publisher
Elsevier
external identifiers
  • pmid:10441178
  • scopus:0032765523
ISSN
0896-8411
DOI
10.1006/jaut.1999.0305
language
English
LU publication?
yes
id
ecdb18cb-40b9-49fa-aa94-fd54fe4777f6 (old id 1114837)
date added to LUP
2008-07-07 09:15:22
date last changed
2017-01-01 04:55:23
@article{ecdb18cb-40b9-49fa-aa94-fd54fe4777f6,
  abstract     = {Systemic lupus erythematosus is a disease of unknown etiology. Multiple genetic factors are believed to be involved in its pathogenesis. In addition, and due to genetic heterogeneity, these factors and/or their combinations may be different in different ethnic groups, while some might be shared between populations. We have performed genome scans in multicase families from three different population groups, two from Northern Europe, with a high degree of homogeneity, and the third from a recently admixed population of Mexican Mestizos. Although our family material is relatively small, the results presented here show that using family sets from well defined populations are sufficient to detect susceptibility loci for SLE. Our results also reveal the chromosomal regions most likely to contain susceptibility genes for SLE.},
  author       = {Johanneson, B and Steinsson, K and Lindqvist, A K and Kristjansdottir, H and Grondal, G and Sandino, S and Tjernström, Fredrik and Sturfelt, Gunnar and Granados-Arriola, J and Alcocer-Varela, J and Lundberg, I and Jonasson, I and Truedsson, Lennart and Svenungsson, E and Klareskog, L and Alarcon-Segovia, D},
  issn         = {0896-8411},
  keyword      = {systemic lupus erythematosus,genetics,autoimmunity,genome-scan,linkage analysis},
  language     = {eng},
  number       = {1},
  pages        = {137--141},
  publisher    = {Elsevier},
  series       = {Journal of Autoimmunity},
  title        = {A comparison of genome-scans performed in multicase families with systemic lupus erythematosus from different population groups},
  url          = {http://dx.doi.org/10.1006/jaut.1999.0305},
  volume       = {13},
  year         = {1999},
}