Changes in levels of factor VII and protein S after acute myocardial infarction: effects of low-dose warfarin
(1999) In Thrombosis Research 96(3). p.205-212- Abstract
- Persistent coagulation activity after an acute myocardial infarction may increase the risk of reinfarction. We prospectively investigated the effects on plasma coagulation of a low, fixed dose of warfarin in combination with aspirin after myocardial infarction. We also evaluated the influence of coagulation activity on clinical outcome. Plasma samples from 97 patients, randomised to 1.25 mg of warfarin daily in combination with 75 mg of aspirin or aspirin alone were drawn 4 days, 1 month, and 6 months after myocardial infarction. Patients receiving warfarin had a greater reduction in factor VII coagulation activity (FVII:C) after 6 months: 0.18 vs. 0.06 U/mL,(95% CI, 0.02-0.22), whereas no differences were seen in levels of protein C,... (More)
- Persistent coagulation activity after an acute myocardial infarction may increase the risk of reinfarction. We prospectively investigated the effects on plasma coagulation of a low, fixed dose of warfarin in combination with aspirin after myocardial infarction. We also evaluated the influence of coagulation activity on clinical outcome. Plasma samples from 97 patients, randomised to 1.25 mg of warfarin daily in combination with 75 mg of aspirin or aspirin alone were drawn 4 days, 1 month, and 6 months after myocardial infarction. Patients receiving warfarin had a greater reduction in factor VII coagulation activity (FVII:C) after 6 months: 0.18 vs. 0.06 U/mL,(95% CI, 0.02-0.22), whereas no differences were seen in levels of protein C, protein S, or prothrombin fragment 1+2. In the acute phase, the level of free protein S was lower than after 6 months in both groups: 25.6 vs. 28.8% (95% CI, 4.19--2.35). Cardiovascular mortality, reinfarction, and stroke were evaluated after 4 years (median). In a survival analysis, every 0.1 U/mL increase in the level of FVII:C1 month after myocardial infarction was associated with an 15% increase in risk of cardiovascular events (95% C1, 1.01-1.30). Warfarin at 1.25 mg daily reduces FVII:C but not systemic thrombin generation measured as prothrombin fragment 1 +2. Low levels of the anticoagulant protein S may contribute to a procoagulant state. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1114912
- author
- Holm, Johan LU ; Hillarp, Andreas LU ; Erhardt, Leif RW LU and Berntorp, Erik LU
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Factor VII, Protein S, Prothrombin fragment 1+2, Warfarin, Myocardial infarction
- in
- Thrombosis Research
- volume
- 96
- issue
- 3
- pages
- 205 - 212
- publisher
- Elsevier
- external identifiers
-
- pmid:10588463
- scopus:0032754587
- ISSN
- 1879-2472
- DOI
- 10.1016/S0049-3848(99)00099-7
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Internal Medicine Research Unit (013242520), Clinical Chemistry, Malmö (013016000), Emergency medicine/Medicine/Surgery (013240200), Clinical Coagulation Research Unit (013242510)
- id
- 14a9600c-6744-492e-8cd3-576721a94b3f (old id 1114912)
- date added to LUP
- 2016-04-01 12:09:37
- date last changed
- 2022-01-26 23:41:49
@article{14a9600c-6744-492e-8cd3-576721a94b3f, abstract = {{Persistent coagulation activity after an acute myocardial infarction may increase the risk of reinfarction. We prospectively investigated the effects on plasma coagulation of a low, fixed dose of warfarin in combination with aspirin after myocardial infarction. We also evaluated the influence of coagulation activity on clinical outcome. Plasma samples from 97 patients, randomised to 1.25 mg of warfarin daily in combination with 75 mg of aspirin or aspirin alone were drawn 4 days, 1 month, and 6 months after myocardial infarction. Patients receiving warfarin had a greater reduction in factor VII coagulation activity (FVII:C) after 6 months: 0.18 vs. 0.06 U/mL,(95% CI, 0.02-0.22), whereas no differences were seen in levels of protein C, protein S, or prothrombin fragment 1+2. In the acute phase, the level of free protein S was lower than after 6 months in both groups: 25.6 vs. 28.8% (95% CI, 4.19--2.35). Cardiovascular mortality, reinfarction, and stroke were evaluated after 4 years (median). In a survival analysis, every 0.1 U/mL increase in the level of FVII:C1 month after myocardial infarction was associated with an 15% increase in risk of cardiovascular events (95% C1, 1.01-1.30). Warfarin at 1.25 mg daily reduces FVII:C but not systemic thrombin generation measured as prothrombin fragment 1 +2. Low levels of the anticoagulant protein S may contribute to a procoagulant state.}}, author = {{Holm, Johan and Hillarp, Andreas and Erhardt, Leif RW and Berntorp, Erik}}, issn = {{1879-2472}}, keywords = {{Factor VII; Protein S; Prothrombin fragment 1+2; Warfarin; Myocardial infarction}}, language = {{eng}}, number = {{3}}, pages = {{205--212}}, publisher = {{Elsevier}}, series = {{Thrombosis Research}}, title = {{Changes in levels of factor VII and protein S after acute myocardial infarction: effects of low-dose warfarin}}, url = {{http://dx.doi.org/10.1016/S0049-3848(99)00099-7}}, doi = {{10.1016/S0049-3848(99)00099-7}}, volume = {{96}}, year = {{1999}}, }