Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies
(2000) In Lupus 9(9). p.664-671- Abstract
- The objective was to investigate the relation between serum levels of interferon-alpha (IFN-alpha), the activity of an endogenous IFN-alpha inducing factor (SLE-IIF), clinical and immunological disease activity as well as serum levels of antiretroviral antibodies in SLE. Serum levels of IFN-alpha were measured in serial sera from 30 patients sampled at different stages of disease activity (SLEDAI score). The SLE-IIF activity was measured by its ability to induce IFN-alpha production in cultures of normal peripheral blood mononuclear cells. Both serum IFN-alpha and SLE-IIF increased markedly at flare in serially followed patients. The SLEDAI score, levels of anti-dsDNA antibodies and IL-10 correlated positively, and complement components... (More)
- The objective was to investigate the relation between serum levels of interferon-alpha (IFN-alpha), the activity of an endogenous IFN-alpha inducing factor (SLE-IIF), clinical and immunological disease activity as well as serum levels of antiretroviral antibodies in SLE. Serum levels of IFN-alpha were measured in serial sera from 30 patients sampled at different stages of disease activity (SLEDAI score). The SLE-IIF activity was measured by its ability to induce IFN-alpha production in cultures of normal peripheral blood mononuclear cells. Both serum IFN-alpha and SLE-IIF increased markedly at flare in serially followed patients. The SLEDAI score, levels of anti-dsDNA antibodies and IL-10 correlated positively, and complement components Clq, C3 and leukocytes correlated inversely with serum concentrations of IFN-alpha. The extent of multiple organ involvement correlated with serum IFN-alpha. No relation between concentrations of retroviral peptide binding antibodies and IFN-alpha or SLE-IIF activity was found. The close relationship between disease activity in SLE patients and IFN-alpha serum levels suggests that activation of the type 1 IFN system might be of importance in the disease process. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1117344
- author
- Bengtsson, Anders LU ; Sturfelt, Gunnar LU ; Truedsson, Lennart LU ; Blomberg, J ; Alm, G ; Vallin, H and Ronnblom, L
- organization
- publishing date
- 2000
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- SLE, interferon-a, retrovirus, SLEDAI, interferon inducer
- in
- Lupus
- volume
- 9
- issue
- 9
- pages
- 664 - 671
- publisher
- SAGE Publications
- external identifiers
-
- pmid:11199920
- scopus:0034533825
- ISSN
- 0961-2033
- DOI
- 10.1191/096120300674499064
- language
- English
- LU publication?
- yes
- id
- 8df4d8ce-c8de-4ff8-b188-f72e9807a163 (old id 1117344)
- date added to LUP
- 2016-04-01 12:07:22
- date last changed
- 2022-04-13 06:27:12
@article{8df4d8ce-c8de-4ff8-b188-f72e9807a163, abstract = {{The objective was to investigate the relation between serum levels of interferon-alpha (IFN-alpha), the activity of an endogenous IFN-alpha inducing factor (SLE-IIF), clinical and immunological disease activity as well as serum levels of antiretroviral antibodies in SLE. Serum levels of IFN-alpha were measured in serial sera from 30 patients sampled at different stages of disease activity (SLEDAI score). The SLE-IIF activity was measured by its ability to induce IFN-alpha production in cultures of normal peripheral blood mononuclear cells. Both serum IFN-alpha and SLE-IIF increased markedly at flare in serially followed patients. The SLEDAI score, levels of anti-dsDNA antibodies and IL-10 correlated positively, and complement components Clq, C3 and leukocytes correlated inversely with serum concentrations of IFN-alpha. The extent of multiple organ involvement correlated with serum IFN-alpha. No relation between concentrations of retroviral peptide binding antibodies and IFN-alpha or SLE-IIF activity was found. The close relationship between disease activity in SLE patients and IFN-alpha serum levels suggests that activation of the type 1 IFN system might be of importance in the disease process.}}, author = {{Bengtsson, Anders and Sturfelt, Gunnar and Truedsson, Lennart and Blomberg, J and Alm, G and Vallin, H and Ronnblom, L}}, issn = {{0961-2033}}, keywords = {{SLE; interferon-a; retrovirus; SLEDAI; interferon inducer}}, language = {{eng}}, number = {{9}}, pages = {{664--671}}, publisher = {{SAGE Publications}}, series = {{Lupus}}, title = {{Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies}}, url = {{http://dx.doi.org/10.1191/096120300674499064}}, doi = {{10.1191/096120300674499064}}, volume = {{9}}, year = {{2000}}, }