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Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies

Bengtsson, Anders LU ; Sturfelt, Gunnar LU ; Truedsson, Lennart LU ; Blomberg, J; Alm, G; Vallin, H and Ronnblom, L (2000) In Lupus 9(9). p.664-671
Abstract
The objective was to investigate the relation between serum levels of interferon-alpha (IFN-alpha), the activity of an endogenous IFN-alpha inducing factor (SLE-IIF), clinical and immunological disease activity as well as serum levels of antiretroviral antibodies in SLE. Serum levels of IFN-alpha were measured in serial sera from 30 patients sampled at different stages of disease activity (SLEDAI score). The SLE-IIF activity was measured by its ability to induce IFN-alpha production in cultures of normal peripheral blood mononuclear cells. Both serum IFN-alpha and SLE-IIF increased markedly at flare in serially followed patients. The SLEDAI score, levels of anti-dsDNA antibodies and IL-10 correlated positively, and complement components... (More)
The objective was to investigate the relation between serum levels of interferon-alpha (IFN-alpha), the activity of an endogenous IFN-alpha inducing factor (SLE-IIF), clinical and immunological disease activity as well as serum levels of antiretroviral antibodies in SLE. Serum levels of IFN-alpha were measured in serial sera from 30 patients sampled at different stages of disease activity (SLEDAI score). The SLE-IIF activity was measured by its ability to induce IFN-alpha production in cultures of normal peripheral blood mononuclear cells. Both serum IFN-alpha and SLE-IIF increased markedly at flare in serially followed patients. The SLEDAI score, levels of anti-dsDNA antibodies and IL-10 correlated positively, and complement components Clq, C3 and leukocytes correlated inversely with serum concentrations of IFN-alpha. The extent of multiple organ involvement correlated with serum IFN-alpha. No relation between concentrations of retroviral peptide binding antibodies and IFN-alpha or SLE-IIF activity was found. The close relationship between disease activity in SLE patients and IFN-alpha serum levels suggests that activation of the type 1 IFN system might be of importance in the disease process. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
SLE, interferon-a, retrovirus, SLEDAI, interferon inducer
in
Lupus
volume
9
issue
9
pages
664 - 671
publisher
SAGE Publications
external identifiers
  • pmid:11199920
  • scopus:0034533825
ISSN
0961-2033
DOI
10.1191/096120300674499064
language
English
LU publication?
yes
id
8df4d8ce-c8de-4ff8-b188-f72e9807a163 (old id 1117344)
date added to LUP
2008-07-03 11:20:54
date last changed
2017-08-20 03:39:00
@article{8df4d8ce-c8de-4ff8-b188-f72e9807a163,
  abstract     = {The objective was to investigate the relation between serum levels of interferon-alpha (IFN-alpha), the activity of an endogenous IFN-alpha inducing factor (SLE-IIF), clinical and immunological disease activity as well as serum levels of antiretroviral antibodies in SLE. Serum levels of IFN-alpha were measured in serial sera from 30 patients sampled at different stages of disease activity (SLEDAI score). The SLE-IIF activity was measured by its ability to induce IFN-alpha production in cultures of normal peripheral blood mononuclear cells. Both serum IFN-alpha and SLE-IIF increased markedly at flare in serially followed patients. The SLEDAI score, levels of anti-dsDNA antibodies and IL-10 correlated positively, and complement components Clq, C3 and leukocytes correlated inversely with serum concentrations of IFN-alpha. The extent of multiple organ involvement correlated with serum IFN-alpha. No relation between concentrations of retroviral peptide binding antibodies and IFN-alpha or SLE-IIF activity was found. The close relationship between disease activity in SLE patients and IFN-alpha serum levels suggests that activation of the type 1 IFN system might be of importance in the disease process.},
  author       = {Bengtsson, Anders and Sturfelt, Gunnar and Truedsson, Lennart and Blomberg, J and Alm, G and Vallin, H and Ronnblom, L},
  issn         = {0961-2033},
  keyword      = {SLE,interferon-a,retrovirus,SLEDAI,interferon inducer},
  language     = {eng},
  number       = {9},
  pages        = {664--671},
  publisher    = {SAGE Publications},
  series       = {Lupus},
  title        = {Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies},
  url          = {http://dx.doi.org/10.1191/096120300674499064},
  volume       = {9},
  year         = {2000},
}