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Bone loss following tibial osteotomy: a model for evaluating post-traumatic osteopenia

Karlsson, M K; Josefsson, P O; Nordkvist, A; Åkesson, Kristina LU ; Seeman, E and Obrant, Karl LU (2000) In Osteoporosis International 11(3). p.261-264
Abstract
The reduced bone mineral density (BMD) found in patients with fractures may, in part, follow rather than precede the fracture. We studied the magnitude and reversibility of bone loss in the 15 months following osteotomy in 21 men and 5 women with localized medial arthritis of the knee. BMD (mean +/- SD), measured using dual-energy X-ray absorptiometry, decreased by a maximum of 35 +/- 21% in the mid-diaphysis of the affected tibia at 9 months after surgery (p < 0.001). At 15 months, reversal of bone loss in non-fractured bones was incomplete; the remaining deficit was 20 +/- 27% relative to baseline (p < 0.001). Maximum bone loss occurred at 9 months at the total body (5 +/- 2%), spine (15 +/- 17%) and at Ward's triangle of the... (More)
The reduced bone mineral density (BMD) found in patients with fractures may, in part, follow rather than precede the fracture. We studied the magnitude and reversibility of bone loss in the 15 months following osteotomy in 21 men and 5 women with localized medial arthritis of the knee. BMD (mean +/- SD), measured using dual-energy X-ray absorptiometry, decreased by a maximum of 35 +/- 21% in the mid-diaphysis of the affected tibia at 9 months after surgery (p < 0.001). At 15 months, reversal of bone loss in non-fractured bones was incomplete; the remaining deficit was 20 +/- 27% relative to baseline (p < 0.001). Maximum bone loss occurred at 9 months at the total body (5 +/- 2%), spine (15 +/- 17%) and at Ward's triangle of the proximal femur of the unoperated limb (10 +/- 17%) (all p < 0.01). In summary, post-traumatic bone loss is region-specific with incomplete reversibility, at least after about 15 months. Deficits in BMD in cross-sectional studies of patients with fractures, held to be responsible for the bone fragility, may, in part, follow rather than precede the fracture. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dual-energy X-ray absorptiometry, Fracture, Post-traumatic osteopenia, Tibial osteotomy
in
Osteoporosis International
volume
11
issue
3
pages
261 - 264
publisher
Springer
external identifiers
  • pmid:10824243
  • scopus:0033998395
ISSN
1433-2965
DOI
10.1007/s001980050290
language
English
LU publication?
yes
id
5a9d01dc-dc42-422a-af19-5e696f705ca7 (old id 1117445)
date added to LUP
2008-07-01 08:24:01
date last changed
2017-01-01 06:58:22
@article{5a9d01dc-dc42-422a-af19-5e696f705ca7,
  abstract     = {The reduced bone mineral density (BMD) found in patients with fractures may, in part, follow rather than precede the fracture. We studied the magnitude and reversibility of bone loss in the 15 months following osteotomy in 21 men and 5 women with localized medial arthritis of the knee. BMD (mean +/- SD), measured using dual-energy X-ray absorptiometry, decreased by a maximum of 35 +/- 21% in the mid-diaphysis of the affected tibia at 9 months after surgery (p &lt; 0.001). At 15 months, reversal of bone loss in non-fractured bones was incomplete; the remaining deficit was 20 +/- 27% relative to baseline (p &lt; 0.001). Maximum bone loss occurred at 9 months at the total body (5 +/- 2%), spine (15 +/- 17%) and at Ward's triangle of the proximal femur of the unoperated limb (10 +/- 17%) (all p &lt; 0.01). In summary, post-traumatic bone loss is region-specific with incomplete reversibility, at least after about 15 months. Deficits in BMD in cross-sectional studies of patients with fractures, held to be responsible for the bone fragility, may, in part, follow rather than precede the fracture.},
  author       = {Karlsson, M K and Josefsson, P O and Nordkvist, A and Åkesson, Kristina and Seeman, E and Obrant, Karl},
  issn         = {1433-2965},
  keyword      = {Dual-energy X-ray absorptiometry,Fracture,Post-traumatic osteopenia,Tibial osteotomy},
  language     = {eng},
  number       = {3},
  pages        = {261--264},
  publisher    = {Springer},
  series       = {Osteoporosis International},
  title        = {Bone loss following tibial osteotomy: a model for evaluating post-traumatic osteopenia},
  url          = {http://dx.doi.org/10.1007/s001980050290},
  volume       = {11},
  year         = {2000},
}