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Regimens of factor VIII administration--continuous infusion vs. bolus

Berntorp, Erik LU (2000) In Haematologica 85(10 Suppl). p.69-69
Abstract
The Malmo protocol for immune tolerance induction uses intermittent injections of factor VIII/IX together with intravenous IgG and cyclophosphamide. In order to increase the production of antigen-antibody complexes, and also to improve cost-efficacy, we applied continuous infusion instead of intermittent injection in 5 high-responders (3 hemophilia A and 2 hemophilia B). All treatment attempts failed. However, we conclude that continuous infusion may play a role in immune tolerance induction, and the treatment failures in our study could probably be explained by the fact that the patients were partially selected to be resistant cases.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Haematologica
volume
85
issue
10 Suppl
pages
69 - 69
publisher
Ferrata Storti Foundation
external identifiers
  • pmid:11187875
  • scopus:0033710126
ISSN
1592-8721
language
English
LU publication?
yes
id
6b42d2c4-3aab-4226-a496-6af858e7cf11 (old id 1117532)
date added to LUP
2008-06-27 14:15:53
date last changed
2017-01-01 07:09:31
@article{6b42d2c4-3aab-4226-a496-6af858e7cf11,
  abstract     = {The Malmo protocol for immune tolerance induction uses intermittent injections of factor VIII/IX together with intravenous IgG and cyclophosphamide. In order to increase the production of antigen-antibody complexes, and also to improve cost-efficacy, we applied continuous infusion instead of intermittent injection in 5 high-responders (3 hemophilia A and 2 hemophilia B). All treatment attempts failed. However, we conclude that continuous infusion may play a role in immune tolerance induction, and the treatment failures in our study could probably be explained by the fact that the patients were partially selected to be resistant cases.},
  author       = {Berntorp, Erik},
  issn         = {1592-8721},
  language     = {eng},
  number       = {10 Suppl},
  pages        = {69--69},
  publisher    = {Ferrata Storti Foundation},
  series       = {Haematologica},
  title        = {Regimens of factor VIII administration--continuous infusion vs. bolus},
  volume       = {85},
  year         = {2000},
}