Effect kinetics of desmopressin-induced platelet retention in healthy volunteers treated with aspirin or placebo
(2000) In Haemophilia 6(1). p.15-20- Abstract
- Desmopressin is often used for haemostatic treatment in platelet dysfunction, but the effect kinetics of platelet responses and the mechanism of action are poorly known. This study aimed to determine the kinetics of platelet function responses induced by desmopressin in healthy volunteers treated with aspirin or placebo. Another aim was to correlate platelet responses to changes of von Willebrand factor (vWF) in plasma. We measured platelet function with a glass bead retention test, Ivy bleeding time, vWF:Ag and multimeric structure in plasma. Median baseline platelet retention was 12% (normal reference range 16-27%) during aspirin treatment and 18% during placebo. Median peak platelet retention after desmopressin was 33% during aspirin... (More)
- Desmopressin is often used for haemostatic treatment in platelet dysfunction, but the effect kinetics of platelet responses and the mechanism of action are poorly known. This study aimed to determine the kinetics of platelet function responses induced by desmopressin in healthy volunteers treated with aspirin or placebo. Another aim was to correlate platelet responses to changes of von Willebrand factor (vWF) in plasma. We measured platelet function with a glass bead retention test, Ivy bleeding time, vWF:Ag and multimeric structure in plasma. Median baseline platelet retention was 12% (normal reference range 16-27%) during aspirin treatment and 18% during placebo. Median peak platelet retention after desmopressin was 33% during aspirin treatment and 34% during placebo. After about 3 h platelet function had returned to baseline. A second desmopressin dose after 3 h stimulated platelet retention to a similar extent as the first dose. There was no correlation between platelet responses and quantitative or qualitative changes of vWF in plasma. Platelet count did not change significantly. Thus, desmopressin's effect on platelet function lasts for about 3 h, but may be prolonged by a second dose immediately thereafter. These findings may have important clinical implications for patients with aspirin-induced platelet dysfunction undergoing surgery. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1117578
- author
- Lethagen, Stefan LU ; Olofsson, L ; Frick, K ; Berntorp, Erik LU and Björkman, S
- organization
- publishing date
- 2000
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Haemophilia
- volume
- 6
- issue
- 1
- pages
- 15 - 20
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:10632736
- scopus:0033994081
- ISSN
- 1351-8216
- DOI
- 10.1046/j.1365-2516.2000.00355.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Clinical Coagulation Research Unit (013242510), Emergency medicine/Medicine/Surgery (013240200)
- id
- e9f7d154-0b4e-4396-9fe7-6b5bd64abf8c (old id 1117578)
- date added to LUP
- 2016-04-01 11:59:21
- date last changed
- 2022-07-22 06:36:11
@article{e9f7d154-0b4e-4396-9fe7-6b5bd64abf8c,
abstract = {{Desmopressin is often used for haemostatic treatment in platelet dysfunction, but the effect kinetics of platelet responses and the mechanism of action are poorly known. This study aimed to determine the kinetics of platelet function responses induced by desmopressin in healthy volunteers treated with aspirin or placebo. Another aim was to correlate platelet responses to changes of von Willebrand factor (vWF) in plasma. We measured platelet function with a glass bead retention test, Ivy bleeding time, vWF:Ag and multimeric structure in plasma. Median baseline platelet retention was 12% (normal reference range 16-27%) during aspirin treatment and 18% during placebo. Median peak platelet retention after desmopressin was 33% during aspirin treatment and 34% during placebo. After about 3 h platelet function had returned to baseline. A second desmopressin dose after 3 h stimulated platelet retention to a similar extent as the first dose. There was no correlation between platelet responses and quantitative or qualitative changes of vWF in plasma. Platelet count did not change significantly. Thus, desmopressin's effect on platelet function lasts for about 3 h, but may be prolonged by a second dose immediately thereafter. These findings may have important clinical implications for patients with aspirin-induced platelet dysfunction undergoing surgery.}},
author = {{Lethagen, Stefan and Olofsson, L and Frick, K and Berntorp, Erik and Björkman, S}},
issn = {{1351-8216}},
language = {{eng}},
number = {{1}},
pages = {{15--20}},
publisher = {{Wiley-Blackwell}},
series = {{Haemophilia}},
title = {{Effect kinetics of desmopressin-induced platelet retention in healthy volunteers treated with aspirin or placebo}},
url = {{http://dx.doi.org/10.1046/j.1365-2516.2000.00355.x}},
doi = {{10.1046/j.1365-2516.2000.00355.x}},
volume = {{6}},
year = {{2000}},
}